Version 2.78

Term Description

A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."
Source: Regenstrief LOINC

Part Description

LP19829-8   t(1;19)(q23.3;p13.3)(PBX1,TCF3)
Chromosomal translocation t(1;19)(q23.3;p13.3) PBX1/TCF3 is caused by a breakpoint in 19p13.3 and occurs in two different forms: 1) a balanced form found in one fourth of cases with a der(1) and a der(19) and 2) an unbalanced form found in 3/4 cases with 2 normal chromosomes 1, a der(19), and 1 normal chromosome 19. This translocation is mostly found in acute lymphoblastic leukemia (ALL), L1/L2 type, as well as L3-like ALL, T-lineage ALL (T-ALL), non-Hodgkin lymphomas (NHL), and acute myeloid leukemias (AML).[Atlas Genetics Oncology:t0119ID1048] Source: Regenstrief LOINC, t(1;19)(q23;p13) TCF3/PBX1

Fully-Specified Name

Component
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript
Property
NRto
Time
Pt
System
Bld/Tiss
Scale
Qn
Method
Molgen

Additional Names

Long Common Name
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name
t(1;19)(PBX1,TCF3)/control Bld/T
Display Name
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info
t(1;19)(q23.3;p13.3)(PBX1,TCF3)/control Transcript, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.TRNLOC
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.42
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
72104-3 Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) t(1;19)(q23.3;p13.3)(PBX1,TCF3) Tránscritos de fusión/transcrito control:Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MX Spanish (Mexico) t (1; 19) (q23.3; p13.3) (PBX1, TCF3) transcripción de fusión / transcripción de control:Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FR French (France) t(1;19)(q23.3;p13.3)(PBX1,TCF3) transcrit de fusion/transcrit de référence:Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
fr-CA French (Canada) t(1;19)(q23.3;p13.3)(PBX1,TCF3) transcrit de fusion/Transcrit de contrôle:Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
it-IT Italian (Italy) t(1;19)(q23.3;p13.3)(PBX1,TCF3), trascritto di fusione/trascritto di controllo:NRto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NL Dutch (Netherlands) t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusietranscript/controle transcript:aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: molgen
pt-BR Portuguese (Brazil) t(1;19)(q23.3;p13.3)(PBX1,TCF3) transcrição de fusão/controle de transcrição::Pt:Sg/Tecido:Qn:Genética molecular
ru-RU Russian (Russian Federation) t(1;19)(q23.3;p13.3)(PBX1,TCF3) слияния транскрипт/контрольный транскрипт:КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен
Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR Turkish (Turkey) t(1;19)(q23.3;p13.3)(PBX1,TCF3) füzyon transkript/kontrol transkripti:SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CN Chinese (China) t(1;19)(q23.3;p13.3)(PBX1,TCF3) 融合转录物/对照转录物:计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: Ⅰ E2A 免疫球蛋白增强子结合因子 E12/E47 E2A 免疫球蛋白增强子结合因子 E12/E47（E2A Immunoglobulin enhancer binding factors E12/E47） I ITF1 PBXP1 T(1,19)(PBX1,TCF3) 基因易位;T(1,19)(PBX1,TCF3) 易位 免疫球蛋白转录因子 1 免疫球蛋白转录因子 1（Immunoglobulin transcription factor 1，ITF1） 全血或组织;血液/组织;血液或组织 分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 前 B 细胞白血病转录因子-1 前 B-细胞白血病转录因子-1 前 B-细胞白血病转录因子-1（Pre-B cell leukemia transcription factor-1，PBX1，PBXP1） 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液 转录因子 3 转录因子 3（Transcription factor 3，TCF3）

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72312-2