Version 2.77

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase 65 Ab
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IF

Additional Names

Short Name
GAD65 Ab SerPl Ql IF
Display Name
Glutamate decarboxylase 65 Ab IF Ql
Consumer Name Alpha Get Info
Glutamate decarboxylase 65 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
15507

Member of these Groups Get Info

LOINC Group Group Name
LG27801-6 Glutamate decarboxylase 65 Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Anti-GAD65
es-ES Spanish (Spain) Glutamato decarboxilasa 65 Anticuerpos:PrThr:Punto temporal:Suero o Plasma:Ord:Inmunofluorescencia (IF)
es-MX Spanish (Mexico) Glutamato descarboxilasa 65 Ab:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunofluorescencia (IF)
et-EE Estonian (Estonia) Glutamaadi dekarboksülaasi 65 vastased antikehad:PrThr:Pt:S/P:Ord:IF
Synonyms: Järgarvuline Juhuslik Plasma Seerum Seerum või plasma
fr-CA French (Canada) Glutamate décarboxylase 65 , Ac:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:Immunofluorescence
fr-FR French (France) Glutamate décarboxylase 65 anticorps:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunofluorescence
fr-BE French (Belgium) Glutamate décarboxylase 65 Ac:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:Immunofluorescence
Synonyms: Anticorps
it-IT Italian (Italy) Glutammato decarbossilasi 65 Ab:PrThr:Pt:Siero/Plasma:Ord:IF
Synonyms: anticorpo GAD65 Immunofluorescenza (IF) Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) glutamaatdecarboxylase 65 As:aanwezigheid:moment:serum of plasma:ordinaal:immunofluorescentie
Synonyms: antistof; antilichaam IF
pt-BR Portuguese (Brazil) Glutamato descarboxilase 65 Ac:Limiar:Pt:Soro/Plas:Ord:Imunofluorescência
ru-RU Russian (Russian Federation) Глутаматдекарбоксилаза 65 Ат:PrThr:ТчкВрм:Сыв/Плаз:Пор:ИФ
Synonyms: Антитело Иммунофлюоресценция (ИФ) Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Glutamat dekarboksilaz 65 Ab:MevcEşik:Zmlı:Ser/Plaz:Srl:IF
Synonyms: Ak İmmünflorerans Mevcut
zh-CN Chinese (China) 谷氨酸脱羧酶-65 抗体:存在情况或阈值:时间点:血清/血浆:序数型:免疫荧光法
Synonyms: Ab;自身抗体 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆 谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体 谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72523-4