72694-3
Cholinesterase activity panel - Serum or Plasma
Active
2098-2 Cholinesterase [Enzymatic activity/volume] in Serum or Plasma
Part Descriptions
LP14299-9 Cholinesterase
In biochemistry, cholinesterase is a family of enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.
There are two types:
1. Acetylcholinesterase (EC 3.1.1.7) (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.
2. Pseudocholinesterase (EC 3.1.1.8) (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.
The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
The half-life of pseudocholinesterase is approximately 8-16 hours. Pseudocholinesterase levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.
An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Elevation of plasma pseudocholinesterase was observed in 90.5% cases of acute myocardial infarction.
The presence of acetylcholinesterase in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by amniocentesis, and presence of AChE can confirm several common types of birth defect, including abdominal wall defects and neural tube defects.
Butyrylcholinesterase can be used as a prophylactic agent against nerve gas and other organophosphate poisoning
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Cholinesterase (Wikipedia)
LP14299-9 Cholinesterase
Cholinesterase is measured to diagnose organophosphate and carbamate toxicity or identify atypical enzyme forms. RBC levels measured to detect chronic exposure to systemic insecticides. Insecticides inhibit both RBC and plasma cholinesterase levels, but serum levels return to normal before RBC levels normalize. Cholinesterase is irreversibly inhibited by organophosphate insecticides and reversibly inhibited by carbamate insecticides. Information from LOINC partner 1 2006 10 24.
Pseudocholinesterase is also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acyl choline acylhydrolase, found primarily in the liver. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency, which is a silent condition which only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during surgery. Information from en.Wikipedia.org.
Source: Regenstrief Institute
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Cholinesterase
- Property
- CCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- Cholinesterase SerPl-cCnc
- Display Name
- Cholinesterase [Catalytic activity/Vol]
- Consumer Name Alpha Get Info
- Cholinesterase, Blood
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 1.0
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 6728
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72694-3 | Cholinesterase activity panel - Serum or Plasma |
| 35558-6 | Cholinesterase panel [Enzymatic activity/volume] - Blood |
| 35499-3 | Pesticide and Insecticide panel [Mass/volume] - Serum or Plasma |
| 35501-6 | Pesticide and Insecticide panel [Mass/volume] - Urine and Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG246-5 | Cholinesterase| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: Cholinesterase |
| de-DE | German (Germany) | Cholinesterase: Synonyms: CHE |
| es-AR | Spanish (Argentina) | colinesterasa: |
| es-ES | Spanish (Spain) | Colinesterasa: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Colinesterasa: |
| et-EE | Estonian (Estonia) | Koliini esteraas: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-BE | French (Belgium) | Cholinestérase: |
| fr-FR | French (France) | Cholinestérases: |
| fr-CA | French (Canada) | Cholinestérase: |
| it-IT | Italian (Italy) | Colinesterasi: Synonyms: Chimica Concentrazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| ko-KR | Korean (Korea, Republic Of) | 콜린에스테라아제: |
| nl-NL | Dutch (Netherlands) | cholinesterase: |
| pl-PL | Polish (Poland) | Cholinoesteraza: |
| pt-BR | Portuguese (Brazil) | Colinesterase: Synonyms: Pseudocho; |
| ru-RU | Russian (Russian Federation) | Холинэстераза: Synonyms: Каталитическая концентрация Количественный Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Kolinesteraz: |
| uk-UA | Ukrainian (Ukraine) | Холінестераза: Synonyms: Acylcholine acylhydrolase; |
| zh-CN | Chinese (China) | 胆碱酯酶: Synonyms: BChE; |
Example Units
| Unit | Source |
|---|---|
| U/L | Example UCUM Units |
| units/mL | REGENSTRIEF |
39354-6 Cholinesterase in Serum or Plasma --dibucaine/Cholinesterase
Part Descriptions
LP14299-9 Cholinesterase
In biochemistry, cholinesterase is a family of enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.
There are two types:
1. Acetylcholinesterase (EC 3.1.1.7) (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.
2. Pseudocholinesterase (EC 3.1.1.8) (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.
The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
The half-life of pseudocholinesterase is approximately 8-16 hours. Pseudocholinesterase levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.
An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Elevation of plasma pseudocholinesterase was observed in 90.5% cases of acute myocardial infarction.
The presence of acetylcholinesterase in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by amniocentesis, and presence of AChE can confirm several common types of birth defect, including abdominal wall defects and neural tube defects.
Butyrylcholinesterase can be used as a prophylactic agent against nerve gas and other organophosphate poisoning
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Cholinesterase (Wikipedia)
LP14299-9 Cholinesterase
Cholinesterase is measured to diagnose organophosphate and carbamate toxicity or identify atypical enzyme forms. RBC levels measured to detect chronic exposure to systemic insecticides. Insecticides inhibit both RBC and plasma cholinesterase levels, but serum levels return to normal before RBC levels normalize. Cholinesterase is irreversibly inhibited by organophosphate insecticides and reversibly inhibited by carbamate insecticides. Information from LOINC partner 1 2006 10 24.
Pseudocholinesterase is also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acyl choline acylhydrolase, found primarily in the liver. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency, which is a silent condition which only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during surgery. Information from en.Wikipedia.org.
Source: Regenstrief Institute
Observation Required in Panel
Required
Fully-Specified Name
- Component
- Cholinesterase^dibucaine/Cholinesterase
- Property
- CFr
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- Cholinesterase dibucaine/CHe CFr SerPl
- Display Name
- Cholinesterase dibucaine/Cholinesterase [Catalytic fraction]
- Consumer Name Alpha Get Info
- Cholinesterase dibucaine/Cholinesterase, Blood
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.73
- Change Reason
- Changed component from Cholinesterase.dibucaine inhibited to fit the current LOINC model for challenges
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 9001
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72694-3 | Cholinesterase activity panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Colinesterasa ^ dibucaína / colinesterasa: |
| es-ES | Spanish (Spain) | Colinesterasa^Dibucaina/colinesterasa: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cholinestérases inhibées par dibucaïne/cholinestérases totales: |
| fr-CA | French (Canada) | Cholinestérase^dibucaine/Cholinestérase: |
| it-IT | Italian (Italy) | Colinesterasi^dibucaina/Colinesterasi: Synonyms: Chimica Frazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| ko-KR | Korean (Korea, Republic Of) | 콜린에스테라아제.억제디부케인/콜린에스테라아제: |
| nl-NL | Dutch (Netherlands) | cholinesterase^dibucaïne/cholinesterase: |
| pt-BR | Portuguese (Brazil) | Colinesterase.dibucaína inibido/Colinesterase: Synonyms: ; |
| tr-TR | Turkish (Turkey) | Kolinesteraz^dibukain/kolinesteraz: |
| zh-CN | Chinese (China) | 胆碱酯酶^辛可卡因/胆碱酯酶: Synonyms: 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide 2-丁氧基-N-(2-二乙基氨基乙基)喹啉-4-甲酰胺 BChE; |
Example Units
| Unit | Source |
|---|---|
| %{inhibition};% | Example UCUM Units |
39355-3 Cholinesterase.fluoride inhibited/Cholinesterase in Serum or Plasma
Part Descriptions
LP35209-3 Cholinesterase.fluoride inhibited
People with genetic variants or acquired deficiencies of plasma cholinesterase that result in lower enzymatic activity can have a very difficult time recovering from surgery. To identify these patients, tests using various inhibitory agents are performed.
The most common inhibitors are fluoride and dibucaine. The degree to which the agent inhibits the enzyme (fluoride number or dibucaine number) can be used to predict neuromuscular recovery after surgery. Other inhibitors include chloride, RO 020683, and scoline.
Source: Regenstrief LOINC
Observation Required in Panel
Optional
Fully-Specified Name
- Component
- Cholinesterase.fluoride inhibited/Cholinesterase
- Property
- CFr
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- Fluoride Inhib/CHe CFr SerPl
- Display Name
- Cholinesterase.fluoride inhibited/Cholinesterase [Catalytic fraction]
- Consumer Name Alpha Get Info
- Cholinesterase.fluoride inhibited/Cholinesterase, Blood
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.70
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72694-3 | Cholinesterase activity panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Colinesterasa inhibida por fluoruro / Colinesterasa: |
| es-ES | Spanish (Spain) | Colinesterasa. Inhibicion por fluoruro/Colinesterasa: Synonyms: Cuantitativo |
| fr-CA | French (Canada) | Cholinestérase.inhibée par le fluorure/Cholinestérase: |
| fr-FR | French (France) | Cholinestérases inhibées par fluorures/cholinestérases totales: |
| fr-BE | French (Belgium) | Cholinestérase.inhibée par le fluorure/Cholinestérase: Synonyms: F |
| it-IT | Italian (Italy) | Colinesterasi.fluoruro inibito/Colinesterasi: Synonyms: Chimica Frazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| ko-KR | Korean (Korea, Republic Of) | 콜린에스테라아제.억제불화물/콜린에스테라아제: |
| nl-NL | Dutch (Netherlands) | cholinesterase.fluoride geremd/cholinesterase: |
| pl-PL | Polish (Poland) | Ocena aktywności cholinoesterazy hamowanej fluorkami/cholinesteraza: |
| pt-BR | Portuguese (Brazil) | Colinesterase.fluoreto inibidor/Colinesterase: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Холинэстераза.фторид ингибированный/Холинэстераза: Synonyms: Каталитическая фракция Количественный Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Kolinesteraz.florür engellenmiş/Kolinesteraz: |
| zh-CN | Chinese (China) | 胆碱酯酶.氟化物抑制型/胆碱酯酶: Synonyms: BChE BChE; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |