Version 2.77

2098-2 Cholinesterase [Enzymatic activity/volume] in Serum or Plasma

Part Descriptions

LP14299-9   Cholinesterase
In biochemistry, cholinesterase is a family of enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.

There are two types:
1. Acetylcholinesterase (EC 3.1.1.7) (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.
2. Pseudocholinesterase (EC 3.1.1.8) (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.

The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.

The half-life of pseudocholinesterase is approximately 8-16 hours. Pseudocholinesterase levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.

An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Elevation of plasma pseudocholinesterase was observed in 90.5% cases of acute myocardial infarction.
The presence of acetylcholinesterase in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by amniocentesis, and presence of AChE can confirm several common types of birth defect, including abdominal wall defects and neural tube defects.
Butyrylcholinesterase can be used as a prophylactic agent against nerve gas and other organophosphate poisoning Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Cholinesterase (Wikipedia)

LP14299-9   Cholinesterase
Cholinesterase is measured to diagnose organophosphate and carbamate toxicity or identify atypical enzyme forms. RBC levels measured to detect chronic exposure to systemic insecticides. Insecticides inhibit both RBC and plasma cholinesterase levels, but serum levels return to normal before RBC levels normalize. Cholinesterase is irreversibly inhibited by organophosphate insecticides and reversibly inhibited by carbamate insecticides. Information from LOINC partner 1 2006 10 24.

Pseudocholinesterase is also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acyl choline acylhydrolase, found primarily in the liver. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency, which is a silent condition which only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during surgery. Information from en.Wikipedia.org. Source: Regenstrief Institute

Observation Required in Panel

Required

Fully-Specified Name

Component
Cholinesterase
Property
CCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Cholinesterase SerPl-cCnc
Display Name
Cholinesterase [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Cholinesterase, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
6728

Member of these Panels

LOINC Long Common Name
72694-3 Cholinesterase activity panel - Serum or Plasma
35558-6 Cholinesterase panel [Enzymatic activity/volume] - Blood
35499-3 Pesticide and Insecticide panel [Mass/volume] - Serum or Plasma
35501-6 Pesticide and Insecticide panel [Mass/volume] - Urine and Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG246-5 Cholinesterase|CCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Cholinesterase
de-DE German (Germany) Cholinesterase:Katalytische Konzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
Synonyms: CHE
es-AR Spanish (Argentina) colinesterasa:concentración catalítica:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Colinesterasa:Concentración Catalítica:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Colinesterasa:Concentración catalítica:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Koliini esteraas:CCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-BE French (Belgium) Cholinestérase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Cholinestérases:Catalytique/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-CA French (Canada) Cholinestérase:Concentration catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Colinesterasi:CCnC:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 콜린에스테라아제:촉매농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) cholinesterase:enzymatische activiteit/volume:moment:serum of plasma:kwantitatief:
pl-PL Polish (Poland) Cholinoesteraza:stężenie katalityczne:punkt w czasie:surowica lub osocze:ilościowy:
pt-BR Portuguese (Brazil) Colinesterase:CCnc:Pt:Sor/Plas:Qn:
Synonyms: Pseudocho; CHS; Che; BChE; Benzoylcholinesterase; Butyrylcholine esterase; Pseudocholinesterase; Choline esterase II; Benzoyl cholinesterase; Acylcholine acylhydrolase; Catalytic Concentration; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Холинэстераза:КаталКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Каталитическая концентрация Количественный Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Kolinesteraz:KtlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) Холінестераза:Каталітична Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Acylcholine acylhydrolase; BChE; Benzoyl cholinesterase; Benzoylcholinesterase; Butyrylcholine esterase; Catalytic Concentration; Che; Chemistry; Choline esterase II; CHS; Pl; Plasma; Plsm; Point in time; Pseudocho; Pseudocholinesterase; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR
zh-CN Chinese (China) 胆碱酯酶:催化浓度:时间点:血清/血浆:定量型:
Synonyms: BChE;Che;CHS;Pseudocho;丁酰胆碱酯酶;伪胆碱脂酶;假性胆碱脂酶;假胆碱酯酶;拟胆碱酯酶;胆碱酯酶 II;胆碱酯酶Ⅱ;脂酰胆碱酯酰水解酶;苯甲酰胆碱酯酶;苯酰胆碱酯酶 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

Unit Source
U/L Example UCUM Units
units/mL REGENSTRIEF

39354-6 Cholinesterase in Serum or Plasma --dibucaine/Cholinesterase

Part Descriptions

LP14299-9   Cholinesterase
In biochemistry, cholinesterase is a family of enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.

There are two types:
1. Acetylcholinesterase (EC 3.1.1.7) (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.
2. Pseudocholinesterase (EC 3.1.1.8) (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.

The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.

The half-life of pseudocholinesterase is approximately 8-16 hours. Pseudocholinesterase levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.

An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Elevation of plasma pseudocholinesterase was observed in 90.5% cases of acute myocardial infarction.
The presence of acetylcholinesterase in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by amniocentesis, and presence of AChE can confirm several common types of birth defect, including abdominal wall defects and neural tube defects.
Butyrylcholinesterase can be used as a prophylactic agent against nerve gas and other organophosphate poisoning Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Cholinesterase (Wikipedia)

LP14299-9   Cholinesterase
Cholinesterase is measured to diagnose organophosphate and carbamate toxicity or identify atypical enzyme forms. RBC levels measured to detect chronic exposure to systemic insecticides. Insecticides inhibit both RBC and plasma cholinesterase levels, but serum levels return to normal before RBC levels normalize. Cholinesterase is irreversibly inhibited by organophosphate insecticides and reversibly inhibited by carbamate insecticides. Information from LOINC partner 1 2006 10 24.

Pseudocholinesterase is also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acyl choline acylhydrolase, found primarily in the liver. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency, which is a silent condition which only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during surgery. Information from en.Wikipedia.org. Source: Regenstrief Institute

Observation Required in Panel

Required

Fully-Specified Name

Component
Cholinesterase^dibucaine/Cholinesterase
Property
CFr
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Cholinesterase dibucaine/CHe CFr SerPl
Display Name
Cholinesterase dibucaine/Cholinesterase [Catalytic fraction]
Consumer Name Alpha Get Info
Cholinesterase dibucaine/Cholinesterase, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.73
Change Reason
Changed component from Cholinesterase.dibucaine inhibited to fit the current LOINC model for challenges
Order vs. Observation
Observation
Common Test Rank Get Info
9001

Member of these Panels

LOINC Long Common Name
72694-3 Cholinesterase activity panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Colinesterasa ^ dibucaína / colinesterasa:Fracción catalítica:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Colinesterasa^Dibucaina/colinesterasa:Fracción Catalítica:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Cholinestérases inhibées par dibucaïne/cholinestérases totales:Fraction catalytique:Ponctuel:Sérum/Plasma:Numérique:
fr-CA French (Canada) Cholinestérase^dibucaine/Cholinestérase:Fraction catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Colinesterasi^dibucaina/Colinesterasi:CFr:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Frazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 콜린에스테라아제.억제디부케인/콜린에스테라아제:촉매분획:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) cholinesterase^dibucaïne/cholinesterase:enzymatische fractie:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Colinesterase.dibucaína inibido/Colinesterase:CFr:Pt:Sor/Plas:Qn:
Synonyms: ; Dibucaine Inhib; Dibucaine number; Pseudocho; CHS; Che; BChE; Benzoylcholinesterase; Butyrylcholine esterase; Pseudocholinesterase; Choline esterase II; Benzoyl cholinesterase; Acylcholine acylhydrolase; Fr; Catalytic Fraction; Percent; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Chemistry
tr-TR Turkish (Turkey) Kolinesteraz^dibukain/kolinesteraz:KtlFr:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 胆碱酯酶^辛可卡因/胆碱酯酶:催化分数:时间点:血清/血浆:定量型:
Synonyms: 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide 2-丁氧基-N-(2-二乙基氨基乙基)喹啉-4-甲酰胺 BChE;Che;CHS;Pseudocho;丁酰胆碱酯酶;伪胆碱脂酶;假性胆碱脂酶;假胆碱酯酶;拟胆碱酯酶;胆碱酯酶 II;胆碱酯酶Ⅱ;脂酰胆碱酯酰水解酶;苯甲酰胆碱酯酶;苯酰胆碱酯酶 Chincocaine Dibucaine Nupercainal Nupercaine Percaine Sovcaine 二丁卡因 二丁卡因;地布卡因;狄布卡因;奴白卡因;沙夫卡因;狄步卡因;丁卡因;CAS 85-79-0 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 奴百卡因 时刻;随机;随意;瞬间 沙夫卡因 狄布卡因 盐酸地布卡因 纽白卡因 血清或血浆 辛可卡因 辛可卡因(二丁卡因、地布卡因、狄布卡因、奴白卡因、沙夫卡因、狄步卡因、丁卡因)/胆碱酯酶(Che)

Example Units

Unit Source
%{inhibition};% Example UCUM Units

39355-3 Cholinesterase.fluoride inhibited/Cholinesterase in Serum or Plasma

Part Descriptions

LP35209-3   Cholinesterase.fluoride inhibited
People with genetic variants or acquired deficiencies of plasma cholinesterase that result in lower enzymatic activity can have a very difficult time recovering from surgery. To identify these patients, tests using various inhibitory agents are performed.

The most common inhibitors are fluoride and dibucaine. The degree to which the agent inhibits the enzyme (fluoride number or dibucaine number) can be used to predict neuromuscular recovery after surgery. Other inhibitors include chloride, RO 020683, and scoline. Source: Regenstrief LOINC

Observation Required in Panel

Optional

Fully-Specified Name

Component
Cholinesterase.fluoride inhibited/Cholinesterase
Property
CFr
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Fluoride Inhib/CHe CFr SerPl
Display Name
Cholinesterase.fluoride inhibited/Cholinesterase [Catalytic fraction]
Consumer Name Alpha Get Info
Cholinesterase.fluoride inhibited/Cholinesterase, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.15
Last Updated
Version 2.70
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
72694-3 Cholinesterase activity panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Colinesterasa inhibida por fluoruro / Colinesterasa:Fracción catalítica:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Colinesterasa. Inhibicion por fluoruro/Colinesterasa:Fracción Catalítica:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-CA French (Canada) Cholinestérase.inhibée par le fluorure/Cholinestérase:Fraction catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Cholinestérases inhibées par fluorures/cholinestérases totales:Fraction catalytique:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Cholinestérase.inhibée par le fluorure/Cholinestérase:Fraction catalytique:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: F
it-IT Italian (Italy) Colinesterasi.fluoruro inibito/Colinesterasi:CFr:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Frazione Catalitica Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 콜린에스테라아제.억제불화물/콜린에스테라아제:촉매분획:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) cholinesterase.fluoride geremd/cholinesterase:enzymatische fractie:moment:serum of plasma:kwantitatief:
pl-PL Polish (Poland) Ocena aktywności cholinoesterazy hamowanej fluorkami/cholinesteraza:frakcja katalityczna:punkt w czasie:surowica lub osocze:ilościowy:
pt-BR Portuguese (Brazil) Colinesterase.fluoreto inibidor/Colinesterase:CFr:Pt:Sor/Plas:Qn:
Synonyms: ; Fluoride Inhib; Fluoride number; Fl; Pseudocho; CHS; Che; BChE; Benzoylcholinesterase; Butyrylcholine esterase; Pseudocholinesterase; Choline esterase II; Benzoyl cholinesterase; Acylcholine acylhydrolase; Fr; Catalytic Fraction; Percent; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Холинэстераза.фторид ингибированный/Холинэстераза:КаталФрак:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Каталитическая фракция Количественный Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Kolinesteraz.florür engellenmiş/Kolinesteraz:KtlFr:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 胆碱酯酶.氟化物抑制型/胆碱酯酶:催化分数:时间点:血清/血浆:定量型:
Synonyms: BChE BChE;Che;CHS;Pseudocho;丁酰胆碱酯酶;伪胆碱脂酶;假性胆碱脂酶;假胆碱酯酶;拟胆碱酯酶;胆碱酯酶 II;胆碱酯酶Ⅱ;脂酰胆碱酯酰水解酶;苯甲酰胆碱酯酶;苯酰胆碱酯酶 Fl;氟;氟离子 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 氟化物数;胆碱酯酶.氟化物抑制;胆碱酯酶.氟化物抑制性 血清或血浆

Example Units

Unit Source
% Example UCUM Units