Version 2.78

Term Description

A patient's genotype for the CYP2B6 gene is typically reported as *A/*B where A is the allele from one chromosome and B is the allele from the other chromosome. The genotype is determined by the analysis of specific single nucleotide polymorphisms (SNPs) within the gene by various molecular techniques, including PCR and microarray. A number of variants within this gene are associated with altered drug metabolism have been described, including *8 (415A>G), *9 (516G>T), *16 (983T>C), and *5 (1459C>T). In some cases, SNP results are analyzed by bioinformatics computer software to determine a patient's overall genotype.
Source: Regenstrief LOINC

Part Description

LP417566-9   CYP2B6 gene allele
Cytochrome P450-2B6 (CYP2B6; [HGNC Gene ID: 2615]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of a number of clinically relevant substrates in current clinical use. Genetic variations in CYP2B6 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2B6 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2B6 genetic variations. See https://www.pharmgkb.org/gene/PA123for more information and dosing guidelines for drugs impacted by CYP2B6 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
CYP2B6 gene allele
Property
Geno
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Long Common Name
CYP2B6 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Short Name
CYP2B6 allele Geno Bld/T
Display Name
CYP2B6 gene allele genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
CYP2B6 gene allele genotype, Blood or tissue specimen

Example Answer List: LL2249-2

Source: Regenstrief LOINC
Answer Code Score Answer ID
CYP2B6*1/*1 LA19167-8
CYP2B6*1/*18 LA19166-0
CYP2B6*1/*4 LA19168-6

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.44
Last Updated
Version 2.68
Change Reason
Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP2B6*1/*8 ), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; Previous Releases: Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Alelo del gen CYP2B6:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Alelo del gen CYP2B6:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) CYP2B6 gène allèle:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) CYP2B6, gene allele:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene CYP2B6 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP2B6-allel:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: molgen
pt-BR Portuguese (Brazil) CYP2B6 gene análise de mutação:Ident:Pt:Sg/Tecido:Nom:Genética molecular
zh-CN Chinese (China) CYP2B6 基因等位基因:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: cytochrome P450, family 2, subfamily B, polypeptide 6;细胞色素 P450, 家族 2, 亚家族 B, 多肽 6;CYP2B6 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

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