4548-4 Hemoglobin A1c/Hemoglobin.total in Blood

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Reference Information

TypeSourceReference
Mapping GuidanceRegenstrief HelpToday, all US HbA1c measurements reported in the US and many other countries are standardized to the NGSP protocol and that has been true for years. This code [LOINC: 4548-4] should be used for reporting the HbA1c in the US. Other countries may report HbA1c measured by the IFCC protocol [LOINC: 59261-8], a protocol with results reported in units of mmol/mol. In Japan and parts of Spain it may be measured using the Japanese protocol. All three protocols produce different numeric values. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total
Property
MFr
Time
Pt
System
Bld
Scale
Qn
Method

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73 (MIN)
Change Reason
Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.; Previous Releases: Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.
Order vs. Observation
Both
Common Test Rank Get Info
88

Member of these Panels

LOINCLong Common Name
52745-7Continuity Assessment Record and Evaluation (CARE) tool - Post Acute Care (PAC) - Discharge
52743-2Deprecated Continuity Assessment Record and Evaluation (CARE) tool - Acute Care
52748-1Deprecated Continuity Assessment Record and Evaluation (CARE) tool - Home Health Admission
52746-5Deprecated Continuity Assessment Record and Evaluation (CARE) tool - Interim
52744-0Deprecated Continuity Assessment Record and Evaluation (CARE) tool - Post Acute Care (PAC) - Admission
55399-0Diabetes tracking panel
67868-0End Stage Renal Disease (ESRD) Medical Evidence Report, Medicare Entitlement AndOr Patient Registration - OMB CMS form 2728
54037-7HEDIS 2009 panel
57820-3HEDIS 2010 panel
60442-1HEDIS 2011 panel
67767-4HEDIS 2012 panel
72199-3HEDIS 2013 panel
74234-6HEDIS 2014 Value Sets
75868-0HEDIS 2015 Value Sets
79544-3HEDIS 2016 Value Sets
82955-6HEDIS 2017 Value Sets
87625-0HEDIS 2018 Value Sets
90766-7HEDIS 2019 Value Sets
94137-7HEDIS 2020 Value Sets
96068-2HEDIS MY 2020 Value Sets
112870-1Hemoglobin A1c and estimated average glucose panel - Blood
43150-2Hemoglobin A1c measurement device panel

Member of these Groups Get Info

LOINC GroupGroup Name
LG51070-7Hemoglobin A1c/Hemoglobin.total|MFr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
ar-JOArabic (Jordan)الهيموغلوبين السكري الكلي " الخضاب السكري " في الدم
cs-CZCzech (Czechia)Hemoglobin A1c/hemoglobin.celkový:Hmotnostní podíl:Časový bod:Krev:Kvantitativní:
de-ATGerman (Austria)Synonyms: Hämoglobin A1c
de-DEGerman (Germany)Hämoglobin A1c/Hämoglobin.gesamt:Massenfraktion:Zeitpunkt:Blut:Quantitativ:
Synonyms: HbA1c
el-GRGreek (Greece)Αιμοσφαιρίνη A1c/Αιμοσφαιρίνη.ολική:MFr:Pt:Αίμα:Qn:
Synonyms: CHEM MFr Pt Qn Αίμα Αιμοσφαιρίνη Αιμοσφαιρίνη A1c Αιμοσφαιρίνη.ολική
es-ARSpanish (Argentina)hemoglobina A1c/hemoglobina.total:fracción de masa:punto en el tiempo:sangre:cuantitativo:
es-ESSpanish (Spain)Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Hemoglobina A1c / Hemoglobina total:Fracción de masa:Punto temporal:Sangre:Cuantitativo:
et-EEEstonian (Estonia)Hemoglobiin A1c/hemoglobiin.üld:MFr:Pt:B:Qn:
Synonyms: Glükohemoglobiin Juhuslik Kvantitatiivne Veri
fr-CAFrench (Canada)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:
fr-FRFrench (France)Hémoglobine A1c/hémoglobine totale:Fraction massique:Ponctuel:Sang:Numérique:
fr-BEFrench (Belgium)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:
Synonyms: Hb Hb.totale HbA1c
it-ITItalian (Italy)Emoglobina A1c/Emoglobina.totale:MFr:Pt:Sangue:Qn:
Synonyms: Chimica Emoglobina A1c (HgB glicata ) Frazione di massa Punto nel tempo (episodio) Sangue
ko-KRKorean (Korea, Republic Of)혈색소 A1C/총혈색소:질량분획:검사시점:전혈:정량:
nl-NLDutch (Netherlands)hemoglobine A1c/hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:
pl-PLPolish (Poland)Hemoglobina A1c/hemoglobina.całkowita:frakcja masowa:punkt w czasie:krew:ilościowy:
Synonyms: Hemoglobina A1c/Hemoglobina całkowita
pt-BRPortuguese (Brazil)Hemoglobina A1c/Hemoglobina.total:SFr:Pt:SgTotal:Qn:
Synonyms: ; Hgb A1c; Glycohemogolobin; Glycohaemogolobin; GHb; HA1c; HBA1c; Glycated hemoglobin; Glycosylated hemoglobin; Hb; Haemoglobin; Substance fraction; Percent; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Tot; Totl; HEMATOLOGY/CELL COUNTS; HEMATOLOGY/CELL COUNTS
ru-RURussian (Russian Federation)Гемоглобин А1с/Гемоглобин.общий:МассДол:ТчкВрм:Кр:Колич:
Synonyms: Количественный Кровь Массовая доля Точка во времени;Момент
tr-TRTurkish (Turkey)Hemoglobin A1c/Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:
uk-UAUkrainian (Ukraine)Гемоглобін A1c/Гемоглобін загальний:Масова Фракція:МоментЧасу:Кров:Кількісно:
Synonyms: Blood; Chemistry; Endocrine; Endocrinology; GHb; Glycated hemoglobin; Glycohaemogolobin; Glycohemogolobin; Glycosylated hemoglobin; HA1c; Haemoglobin; Hb; HbA1c; Hgb; Hgb A1c; Mass fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; Tot; Totl; WB; Whole blood
zh-CNChinese (China)血红蛋白 A1c/血红蛋白.总计:质量分数:时间点:全血:定量型:
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c (糖化血红蛋白) MFr 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总血红蛋白 总量 总额 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 汇总 血;血液

Example Units

UnitSource
%Example UCUM Units
% HgbREGENSTRIEF

4549-2 Hemoglobin A1c/Hemoglobin.total in Blood by Electrophoresis

Term Description

Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total
Property
MFr
Time
Pt
System
Bld
Scale
Qn
Method
Electrophoresis

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73 (MIN)
Change Reason
Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.;
Order vs. Observation
Both
Common Test Rank Get Info
6089

Member of these Panels

LOINCLong Common Name
54037-7HEDIS 2009 panel
57820-3HEDIS 2010 panel
60442-1HEDIS 2011 panel
67767-4HEDIS 2012 panel
72199-3HEDIS 2013 panel
74234-6HEDIS 2014 Value Sets
75868-0HEDIS 2015 Value Sets
79544-3HEDIS 2016 Value Sets
82955-6HEDIS 2017 Value Sets
87625-0HEDIS 2018 Value Sets
90766-7HEDIS 2019 Value Sets
94137-7HEDIS 2020 Value Sets
96068-2HEDIS MY 2020 Value Sets

Member of these Groups Get Info

LOINC GroupGroup Name
LG51070-7Hemoglobin A1c/Hemoglobin.total|MFr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hemoglobin A1c/hemoglobin.celkový:Hmotnostní podíl:Časový bod:Krev:Kvantitativní:Elektroforéza
de-DEGerman (Germany)Hämoglobin A1c/Hämoglobin.gesamt:Massenfraktion:Zeitpunkt:Blut:Quantitativ:Elektrophorese
Synonyms: HbA1c
el-GRGreek (Greece)Αιμοσφαιρίνη A1c/Αιμοσφαιρίνη.ολική:MFr:Pt:Αίμα:Qn:Ηλεκτροφόρηση
Synonyms: CHEM MFr Pt Qn Αίμα Αιμοσφαιρίνη Αιμοσφαιρίνη A1c Αιμοσφαιρίνη.ολική Ηλεκτροφόρηση
es-ARSpanish (Argentina)hemoglobina A1c/hemoglobina.total:fracción de masa:punto en el tiempo:sangre:cuantitativo:electroforesis
es-ESSpanish (Spain)Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:Electroforesis
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Hemoglobina A1c / Hemoglobina total:Fracción de masa:Punto temporal:Sangre:Cuantitativo:Electroforesis
et-EEEstonian (Estonia)Hemoglobiin A1c/hemoglobiin.üld:MFr:Pt:B:Qn:Elektroforees
Synonyms: Glükohemoglobiin Juhuslik Kvantitatiivne Veri
fr-CAFrench (Canada)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:Électrophorèse
fr-FRFrench (France)Hémoglobine A1c/hémoglobine totale:Fraction massique:Ponctuel:Sang:Numérique:Électrophorèse
fr-BEFrench (Belgium)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:Électrophorèse
Synonyms: Hb Hb.totale HbA1c
it-ITItalian (Italy)Emoglobina A1c/Emoglobina.totale:MFr:Pt:Sangue:Qn:Elettroforesi
Synonyms: Chimica Emoglobina A1c (HgB glicata ) Frazione di massa Punto nel tempo (episodio) Sangue
ko-KRKorean (Korea, Republic Of)혈색소 A1C/총혈색소:질량분획:검사시점:전혈:정량:전기영동
nl-NLDutch (Netherlands)hemoglobine A1c/hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:elektroforese
pl-PLPolish (Poland)Hemoglobina A1c/hemoglobina.całkowita:frakcja masowa:punkt w czasie:krew:ilościowy:elektroforeza
Synonyms: Hemoglobina A1c/Hemoglobina całkowita
pt-BRPortuguese (Brazil)Hemoglobina A1c/Hemoglobina.total:SFr:Pt:SgTotal:Qn:Eletroforese
Synonyms: ; Hgb A1c; Glycohemogolobin; Glycohaemogolobin; GHb; HA1c; HBA1c; Glycated hemoglobin; Glycosylated hemoglobin; Hb; Haemoglobin; Substance fraction; Percent; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; Elph; Elp; Elect; Electrophrs; Electrophhrs; Electr; Elec; Ep; Electro; Tot; Totl; HEMATOLOGY/CELL COUNTS; HEMATOLOGY/CELL COUNTS
ru-RURussian (Russian Federation)Гемоглобин А1с/Гемоглобин.общий:МассДол:ТчкВрм:Кр:Колич:Электрофорез
Synonyms: Количественный Кровь Массовая доля Точка во времени;Момент
tr-TRTurkish (Turkey)Hemoglobin A1c/Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:Elektroforez
zh-CNChinese (China)血红蛋白 A1c/血红蛋白.总计:质量分数:时间点:全血:定量型:电泳
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c (糖化血红蛋白) MFr 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总血红蛋白 总量 总额 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 汇总 电泳分析;电泳分析方法;电泳分析类实验室方法;电泳分析类方法;电泳分析类检验方法;电泳方法;电泳类实验室方法;电泳类方法;电泳类检验方法 血;血液

Example Units

UnitSource
%Example UCUM Units

17856-6 Hemoglobin A1c/Hemoglobin.total in Blood by HPLC

Term Description

Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Reference Information

TypeSourceReference
Mapping GuidanceRegenstrief HelpWe do not recommend using this term. All HbA1c tests in US and many other countries are standardized to use [LOINC: 4548-4]. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total
Property
MFr
Time
Pt
System
Bld
Scale
Qn
Method
HPLC

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0l
Last Updated
Version 2.73 (MIN)
Change Reason
Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.;
Order vs. Observation
Both
Common Test Rank Get Info
136

Member of these Panels

LOINCLong Common Name
54037-7HEDIS 2009 panel
57820-3HEDIS 2010 panel
60442-1HEDIS 2011 panel
67767-4HEDIS 2012 panel
72199-3HEDIS 2013 panel
74234-6HEDIS 2014 Value Sets
75868-0HEDIS 2015 Value Sets
79544-3HEDIS 2016 Value Sets
82955-6HEDIS 2017 Value Sets
87625-0HEDIS 2018 Value Sets
90766-7HEDIS 2019 Value Sets
94137-7HEDIS 2020 Value Sets
96068-2HEDIS MY 2020 Value Sets

Member of these Groups Get Info

LOINC GroupGroup Name
LG51070-7Hemoglobin A1c/Hemoglobin.total|MFr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hemoglobin A1c/hemoglobin.celkový:Hmotnostní podíl:Časový bod:Krev:Kvantitativní:Vysokoúčinná kapalinová chromatografie (HPLC)
de-ATGerman (Austria)Synonyms: Hämoglobin A1c
de-DEGerman (Germany)Hämoglobin A1c/Hämoglobin.gesamt:Massenfraktion:Zeitpunkt:Blut:Quantitativ:HPLC
Synonyms: HbA1c
el-GRGreek (Greece)Αιμοσφαιρίνη A1c/Αιμοσφαιρίνη.ολική:MFr:Pt:Αίμα:Qn:Υγρή χρωματογραφία υψηλής πίεσης
Synonyms: CHEM MFr Pt Qn Αίμα Αιμοσφαιρίνη Αιμοσφαιρίνη A1c Αιμοσφαιρίνη.ολική Υγρή χρωματογραφία υψηλής πίεσης
es-ARSpanish (Argentina)hemoglobina A1c/hemoglobina.total:fracción de masa:punto en el tiempo:sangre:cuantitativo:cromatografía líquida de alto rendimiento
es-ESSpanish (Spain)Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:Cromatografía líquida de alta presión
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Hemoglobina A1c / Hemoglobina total:Fracción de masa:Punto temporal:Sangre:Cuantitativo:Cromatografía líquida de alta presión (HPLC)
et-EEEstonian (Estonia)Hemoglobiin A1c/hemoglobiin.üld:MFr:Pt:B:Qn:HPLC
Synonyms: Glükohemoglobiin Juhuslik Kvantitatiivne Veri
fr-CAFrench (Canada)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:HPLC
fr-FRFrench (France)Hémoglobine A1c/hémoglobine totale:Fraction massique:Ponctuel:Sang:Numérique:HPLC
fr-BEFrench (Belgium)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:HPLC
Synonyms: Hb Hb.totale HbA1c
it-ITItalian (Italy)Emoglobina A1c/Emoglobina.totale:MFr:Pt:Sangue:Qn:HPLC
Synonyms: Chimica Cromatografia liquida ad alta pressione (HPLC) Emoglobina A1c (HgB glicata ) Frazione di massa Punto nel tempo (episodio) Sangue
ko-KRKorean (Korea, Republic Of)혈색소 A1C/총혈색소:질량분획:검사시점:전혈:정량:고속 액체 크로마토그래피
nl-NLDutch (Netherlands)hemoglobine A1c/hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:HPLC
pl-PLPolish (Poland)Hemoglobina A1c/hemoglobina.całkowita:frakcja masowa:punkt w czasie:krew:ilościowy:HPLC
Synonyms: Hemoglobina A1c/Hemoglobina całkowita wysokosprawna chromatografia cieczowa
pt-BRPortuguese (Brazil)Hemoglobina A1c/Hemoglobina.total:SFr:Pt:SgTotal:Qn:Cromatografia de alta pressão líquida
Synonyms: ; Hgb A1c; Glycohemogolobin; Glycohaemogolobin; GHb; HA1c; HBA1c; Glycated hemoglobin; Glycosylated hemoglobin; Hb; Haemoglobin; Substance fraction; Percent; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; High pressure liquid chromatography; Tot; Totl; HEMATOLOGY/CELL COUNTS; HEMATOLOGY/CELL COUNTS
ru-RURussian (Russian Federation)Гемоглобин А1с/Гемоглобин.общий:МассДол:ТчкВрм:Кр:Колич:Высокое давление жидкостная хроматография
Synonyms: Жидкостная хроматография высокого давления Количественный Кровь Массовая доля Точка во времени;Момент
tr-TRTurkish (Turkey)Hemoglobin A1c/Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:HPLC
uk-UAUkrainian (Ukraine)Гемоглобін A1c/Гемоглобін.загальний:Масова Фракція:МоментЧасу:Кров:Кількісно:Рідинна хроматографія високого тиску (HPLC)
Synonyms: Blood; Chemistry; Endocrine; Endocrinology; GHb; Glycated hemoglobin; Glycohaemogolobin; Glycohemogolobin; Glycosylated hemoglobin; HA1c; Haemoglobin; Hb; HbA1c; Hgb; Hgb A1c; High performance liquid chromatography; High pressure liquid chromatography; Mass Fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; Tot; Totl; UniversalLabOrders; WB; Whole blood
zh-CNChinese (China)血红蛋白 A1c/血红蛋白.总计:质量分数:时间点:全血:定量型:高效液相色谱分析法
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c (糖化血红蛋白) MFr 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总血红蛋白 总量 总额 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 汇总 血;血液 高压液相色谱;高压液相色谱分析;高压液相色谱分析法;高压液相色谱法;高性能液体色谱;高性能液体色谱分析;高性能液体色谱分析法;高性能液体色谱法;高效液相色谱;高效液相色谱分析;高效液相色谱分析(High Pressure Liquid Chromatography,HPLC);高效液相色谱法

Example Units

UnitSource
%Example UCUM Units
% HgbREGENSTRIEF

59261-8 Hemoglobin A1c/Hemoglobin.total standardized per IFCC-RMP for CDT in Blood

Term Description

This term is not proposed for use in the United States, who will continue to use the NGSP protocol and report the Hgb A1c as %.

Hemoglobin A1c measured using IFCC reference materials. The International Federation of Clinical Chemistry Working Group (IFCC-WG) on HbA1c has recommended a new approach to HbA1c analysis that uses mass spectroscopy and capillary electrophoresis as the reference methods, and set of reference laboratories that use prepared mixtures of purified Hemoglobin A1c and HbA0 as calibrators. (http://www.ngsp.org/prog/IFCCstd.pdf). The IFCC method is reported as millimoles/Mole - which resolves to units that are ten times the value of a pure fraction. The value number produced by the IFCC method differs by less than a factor of ten from the NGSP approach which has been the standard in clinical care since DCCT/UKPDS diabetes studies. A value of 6% under the NGSP method would be 42.8 millimole/mole when tested by the IFFCC approach (per the conversion formula in the above reference). Many countries will report the IFCC value along with the NGSP values and the estimated average glucose - at least for a time. In the US the policies are not as clear and there is at least a chance of no change in the current reporting style will occur. (Source- many- written by CJM 2010 04 27).
Source: Regenstrief Help

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total^^standardized per IFCC-RMP for CDT
Property
SFr
Time
Pt
System
Bld
Scale
Qn
Method

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.32
Last Updated
Version 2.83 (MIN)
Change Reason
Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.;
Order vs. Observation
Both
Common Test Rank Get Info
2804

Member of these Panels

LOINCLong Common Name
67767-4HEDIS 2012 panel
72199-3HEDIS 2013 panel
74234-6HEDIS 2014 Value Sets

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hemoglobin A1c/hemoglobin.celkový:Látkový podíl:Časový bod:Krev:Kvantitativní:IFCC protokol
de-ATGerman (Austria)Synonyms: Hämoglobin A1c IFCC
de-DEGerman (Germany)Hämoglobin A1c/Hämoglobin.gesamt^^standardisiert gemäß Referenzmessverfahren der IFCC für Carbohydrate Deficient Transferrin (CDT):Stoffmengenfraktion:Zeitpunkt:Blut:Quantitativ:
Synonyms: HbA1c
el-GRGreek (Greece)Αιμοσφαιρίνη A1c/Αιμοσφαιρίνη.ολική^^τυποποιημένο κατά IFCC-RMP για CDT:SFr:Pt:Αίμα:Qn:
Synonyms: CHEM Pt Qn SFr Αίμα Αιμοσφαιρίνη Αιμοσφαιρίνη A1c Αιμοσφαιρίνη.ολική τυποποιημένο κατά IFCC-RMP για CDT
es-ESSpanish (Spain)Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total^^Estandarizado de la CDT por la IFCC:Fraccion de sustancia:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Hemoglobina A1c / Hemoglobina total:Fracción de sustancia:Punto temporal:Sangre:Cuantitativo:Protocolo IFCC
fr-FRFrench (France)Hémoglobine A1c/hémoglobine totale^^standardisé par IFCC-RMP pour CDT:Fraction molaire:Ponctuel:Sang:Numérique:
it-ITItalian (Italy)Emoglobina A1c/Emoglobina.totale^^standardizzato secondo IFCC-RMP per CDT:SFr:Pt:Sangue:Qn:
Synonyms: Chimica Emoglobina A1c (HgB glicata ) Frazione di Sostanza Punto nel tempo (episodio) Sangue
nl-NLDutch (Netherlands)hemoglobine A1c/hemoglobine.totaal^^gestandaardiseerd met IFCC-RMP voor CDT:stoffractie:moment:bloed:kwantitatief:
pl-PLPolish (Poland)Hemoglobina A1c/hemoglobina.całkowita^^referencyjna procedura pomiaru transferryny desjalowanej wg IFCC:frakcja molowa:punkt w czasie:krew:ilościowy:
Synonyms: Hemoglobina A1c/Hemoglobina całkowita
uk-UAUkrainian (Ukraine)Гемоглобін A1c/Гемоглобін.загальний:Молярна Фракція:МоментЧасу:Кров:Кількісно:IFCC
Synonyms: Blood; Chemistry; Endocrine; Endocrinology; GHb; Glycated hemoglobin; Glycohaemogolobin; Glycohemogolobin; Glycosylated hemoglobin; HA1c; Haemoglobin; Hb; HbA1c; Hgb; Hgb A1c; International Federation of Clinical Chemistry and Laboratory Medicine; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; Substance fraction; Tot; Totl; WB; Whole blood
zh-CNChinese (China)血红蛋白 A1c/血红蛋白.总计^^按IFCC-RMP针对CDT的参考检测规程加以标准化:物质的量分数:时间点:全血:定量型:
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c (糖化血红蛋白) 克分子分数;摩尔分数 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总血红蛋白 总量 总额 时刻;随机;随意;瞬间 根据国际临床化学与实验室医学联合会(IFCC)的标准,针对缺糖转铁蛋白(CDT,缺乏碳水化合物的转铁蛋白)针对HPLC参考检测规程(RMP);standardized per the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) HPLC reference measurement procedure (RMP) for carbohydrate-deficient transferrin (CD 氧血红蛋白;血红朊;血红素;血色素 汇总 血;血液

Example Units

UnitSource
mmol/molExample UCUM Units

71875-9 Hemoglobin A1c/Hemoglobin.total [Pure mass fraction] in Blood

Term Description

Because of the confusion that occurs in countries that report results as both decimal fraction and percent, this property was created to represent decimal fractions that are reported without units.

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total
Property
MFr.DF
Time
Pt
System
Bld
Scale
Qn
Method

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.73 (MIN)
Change Reason
Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.;
Order vs. Observation
Both
Common Test Rank Get Info
3558

Member of these Panels

LOINCLong Common Name
74234-6HEDIS 2014 Value Sets

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hemoglobin A1c/hemoglobin.celkový:Hmotnostní podíl desetinný:Časový bod:Krev:Kvantitativní:
de-DEGerman (Germany)Hämoglobin A1c/Hämoglobin.gesamt:Massenfraktion.Dezimal:Zeitpunkt:Blut:Quantitativ:
Synonyms: HbA1c
el-GRGreek (Greece)Αιμοσφαιρίνη A1c/Αιμοσφαιρίνη.ολική:MFr.DF:Pt:Αίμα:Qn:
Synonyms: CHEM MFr.DF Pt Qn Αίμα Αιμοσφαιρίνη Αιμοσφαιρίνη A1c Αιμοσφαιρίνη.ολική
es-ESSpanish (Spain)Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total:MFr.DF:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Hemoglobina A1c / Hemoglobina total:Fracción de masa decimal:Punto temporal:Sangre:Cuantitativo:
fr-CAFrench (Canada)Hémoglobine A1c/Hémoglobine.totale:Fraction de masse.DF:Temps ponctuel:Sang:Quantitatif:
fr-FRFrench (France)Hémoglobine A1c/hémoglobine totale:Fraction massique (sans unité):Ponctuel:Sang:Numérique:
it-ITItalian (Italy)Emoglobina A1c/Emoglobina.totale:MFr.DF:Pt:Sangue:Qn:
Synonyms: Chimica Emoglobina A1c (HgB glicata ) Frazione di massa decimale Punto nel tempo (episodio) Sangue
nl-NLDutch (Netherlands)hemoglobine A1c/hemoglobine.totaal:decimale massafractie:moment:bloed:kwantitatief:
pl-PLPolish (Poland)Hemoglobina A1c/hemoglobina.całkowita:frakcja masowa:punkt w czasie:krew:ilościowy:
Synonyms: Hemoglobina A1c/Hemoglobina całkowita
ru-RURussian (Russian Federation)Гемоглобин А1с/Гемоглобин.общий:МасДоля.ДецДоля:ТчкВрм:Кр:Колич:
Synonyms: Десятичное масс отношение Количественный Кровь Точка во времени;Момент
tr-TRTurkish (Turkey)Hemoglobin A1c/Hemoglobin.total:KütlFr.Ondlk:Zmlı:Kan:Kant:
zh-CNChinese (China)血红蛋白 A1c/血红蛋白.总计:质量分数.小数型:时间点:全血:定量型:
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c (糖化血红蛋白) 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总血红蛋白 总量 总额 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 汇总 血;血液 质量分数.小数;小数型质量分数;质量分数.DF

62388-4 Hemoglobin A1c/Hemoglobin.total in Blood by JDS/JSCC protocol

Term Description

Japan is the main country that uses this protocol, but not exclusively.

Part Descriptions

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total
Property
MFr
Time
Pt
System
Bld
Scale
Qn
Method
JDS/JSCC

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.34
Last Updated
Version 2.70 (MIN)
Change Reason
Release 2.70: CLASS: Changed Class from HEM/BC to CHEM as A1C tests are more correctly classified in CHEM.;
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
74234-6HEDIS 2014 Value Sets

Member of these Groups Get Info

LOINC GroupGroup Name
LG51070-7Hemoglobin A1c/Hemoglobin.total|MFr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hemoglobin A1c/hemoglobin.celkový:Hmotnostní podíl:Časový bod:Krev:Kvantitativní:Protokol JDS/JSCC
de-DEGerman (Germany)Hämoglobin A1c/Hämoglobin.gesamt:Massenfraktion:Zeitpunkt:Blut:Quantitativ:Japanese Diabetes Society/Japanese Society for Clinical Chemistry (JDS/JSCC)-Protokoll
Synonyms: HbA1c
el-GRGreek (Greece)Αιμοσφαιρίνη A1c/Αιμοσφαιρίνη.ολική:MFr:Pt:Αίμα:Qn:JDS/JSCC
Synonyms: CHEM JDS/JSCC MFr Pt Qn Αίμα Αιμοσφαιρίνη Αιμοσφαιρίνη A1c Αιμοσφαιρίνη.ολική
es-ESSpanish (Spain)Hemoglobina A1c (Hemoglobina glicosilada)/Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:JDS/JSCC
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Hemoglobina A1c / Hemoglobina total:Fracción de masa:Punto temporal:Sangre:Cuantitativo:Protocolo JDS / JSCC
fr-FRFrench (France)Hémoglobine A1c/hémoglobine totale:Fraction massique:Ponctuel:Sang:Numérique:JDS/JSCC
it-ITItalian (Italy)Emoglobina A1c/Emoglobina.totale:MFr:Pt:Sangue:Qn:JDS/JSCC
Synonyms: Chimica Emoglobina A1c (HgB glicata ) Frazione di massa Protocollo JDS/JSCC Punto nel tempo (episodio) Sangue
nl-NLDutch (Netherlands)hemoglobine A1c/hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:JDS/JSCC
pl-PLPolish (Poland)Hemoglobina A1c/hemoglobina.całkowita:frakcja masowa:punkt w czasie:krew:ilościowy:protokół JDS/JSCC
Synonyms: Hemoglobina A1c/Hemoglobina całkowita
tr-TRTurkish (Turkey)Hemoglobin A1c/Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:JDS/JSCC
zh-CNChinese (China)血红蛋白 A1c/血红蛋白.总计:质量分数:时间点:全血:定量型:JDS/JSCC
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c (糖化血红蛋白) MFr 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总血红蛋白 总量 总额 日本糖尿病协会/临床检验协会方案;日本糖尿病学会/临床检验学会方案;日本糖尿病协会/临床检验协会;日本糖尿病学会/临床检验学会;Japanese Diabetes Society/Japanese Society for Clinical Chemistry;日本糖尿病协会/临床检验协会体系;日本糖尿病学会/临床检验学会体系;JDS-JSCC system;JDS-JSCC reference system 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 汇总 血;血液

Example Units

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