74281-7
Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood
Active
74280-9 Mitogen stimulated gamma interferon positive control spot count [#] in Blood
Term Description
The count of mitogen-stimulated (e.g. phytohemagglutinin, PHA) spots (0 to >50) in a patient's T cells which serves as serves as an IFN-gamma positive control and indicates cell functionality. This term is created for, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT test, the positive control spot count should be greater than or equal to 20 or show saturation (too many spots to count). When the spot count is <20, the result should be considered invalid unless Panel A (ESAT-6) or Panel B (CFP10) are positive or borderline.
Fully-Specified Name
- Component
- Mitogen stimulated gamma interferon.positive control spot count
- Property
- Num
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 10814
Member of these Panels
LOINC | Long Common Name |
---|---|
74281-7 | Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood |
99771-8 | SARS coronavirus 2 spike and nucleocapsid protein stimulated gamma interferon panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Διεγερμένη από μιτογόνα γ-ιντερφερόνη.μέτρηση κηλίδων θετικού ελέγχου: Synonyms: Αρ. Διεγερμένη από μιτογόνα γ-ιντερφερόνη.μέτρηση κηλίδων θετικού ελέγχου Διεγερμένη από μιτογόνα ιντερφερόνη-γ Ιντερφερόνη |
es-ES | Spanish (Spain) | Mitógeno estimulado con interferón gamma control positivo de recuento de manchas: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Recuento de puntos de control positivo de interferón gamma estimulado por mitógenos: |
fr-FR | French (France) | Interféron gamma stimulé par mitogène contrôle positif spots comptés: |
it-IT | Italian (Italy) | Interferone gamma stimolato da mitogeno.controllo positivo numero di spot: Synonyms: Microbiologia Numero (conta) Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | mitogean gestimuleerd gamma-interferon.positieve controle spot count: |
pt-BR | Portuguese (Brazil) | Mitógeno estimulado gama interferon.controle positivo contagem de ponto: |
ru-RU | Russian (Russian Federation) | Митоген стимулированный гамма интерферон.позитивный контроль пятно количество: Synonyms: Количественный Количество Кровь Точка во времени; |
tr-TR | Turkish (Turkey) | Mitogen uyarılmış gamma interferon.pozitif kontrol spot sayım: |
zh-CN | Chinese (China) | 丝裂原刺激型 gamma 干扰素.阳性对照斑点计数: Synonyms: IFN 个数; |
Example Units
Unit | Source |
---|---|
{#} | Example UCUM Units |
74279-1 Gamma interferon negative control spot count [#] in Blood
Term Description
The count of negative control spots (0 to >20) in a patient's T cells incubated without M. tuberculosis antigens (ESAT-6, CFP10). This term is created for, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT.TB test, a typical result is expected to have few to no spots in the negative (nil) control and 20 or more spots in the positive control (Mitogen stimulated). A negative control spot count of >10 is considered invalid.
Fully-Specified Name
- Component
- Gamma interferon.negative control spot count
- Property
- Num
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.46 (MIN)
- Order vs. Observation
- Both
Member of these Panels
LOINC | Long Common Name |
---|---|
74281-7 | Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood |
99771-8 | SARS coronavirus 2 spike and nucleocapsid protein stimulated gamma interferon panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | γ-ιντερφερόνη.μέτρηση κηλίδων αρνητικού ελέγχου: Synonyms: Αρ. Γ-ιντερφερόνη.αρνητικός έλεγχος γ-ιντερφερόνη.μέτρηση κηλίδων αρνητικού ελέγχου Ιντερφερόνη |
es-ES | Spanish (Spain) | Interferón gamma control negativo de recuento de manchas: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Recuento de puntos de control negativo de interferón gamma: |
fr-FR | French (France) | Interféron gamma spots contrôle négatif comptés: |
it-IT | Italian (Italy) | Interferone gamma.controllo negativo numero di spot: Synonyms: Microbiologia Numero (conta) Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | gamma-interferon.negatieve controle spot telling: |
pt-BR | Portuguese (Brazil) | Gama interferon controle negativo contagem de ponto: |
ru-RU | Russian (Russian Federation) | Гамма интерферон.негативный контроль пятно количество: Synonyms: Количественный Количество Кровь Точка во времени; |
tr-TR | Turkish (Turkey) | Gamma interferon.negatif kontrol spot sayım: |
zh-CN | Chinese (China) | Gamma 干扰素.阴性对照斑点计数: Synonyms: Gamma 干扰素(γ干扰素、 |
Example Units
Unit | Source |
---|---|
{#} | Example UCUM Units |
74278-3 Mycobacterium tuberculosis stimulated gamma interferon ESAT-6 Ag spot count [#] in Blood
Term Description
The count of spots (0 to >20) in a patient's T cells that represent IFN-γ released in response to the presence of M. tuberculosis early secretory antigenic target-6 (ESAT-6) antigens. The spot count provides a measurement of the abundance of Mycobacterium tuberculosis sensitive effector T cells in the peripheral blood. This term is based on, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT.TB assay, the test result is positive if [ESAT-6 (Panel A) - negative control spots] and/or [CFP10 (Panel B) - negative control spots] is greater than or equal to 8 spots. The test result is negative if both [Panel A - negative control] and/or [Panel B - negative control] is less than or equal to 4 spots.
Part Descriptions
LP173642-2 Mycobacterium tuberculosis stimulated gamma interferon.ESAT-6 Ag spot count
ESAT-6, the 6 kDa early secretory antigenic target of Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by whole blood interferon γ tests, e.g. QuantiFERON-TB Gold and T-SPOT.TB, in conjunction with CFP-10 and TB7.7 (QuantiFERON-TB Gold). ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, ESAT-6
Fully-Specified Name
- Component
- Mycobacterium tuberculosis stimulated gamma interferon.ESAT-6 Ag spot count
- Property
- Num
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.64 (MIN)
- Order vs. Observation
- Both
Member of these Panels
LOINC | Long Common Name |
---|---|
74281-7 | Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου ESAT-6: Synonyms: Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Αρ. Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου ESAT-6 Ιντερφερόνη |
es-ES | Spanish (Spain) | Mycobacterium tuberculosis estimulado con interferón gamma antígeno ESAT-6 recuento de manchas: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Interferón gamma estimulado por Mycobacterium tuberculosis.ESAT-6 Ag spot count: |
fr-FR | French (France) | Interféron gamma stimulé par mycobacterium tuberculosis antigène ESAT-6 spots comptés: |
it-IT | Italian (Italy) | Interferone gamma stimolato da mycobacterium tuberculosis.antigeni ESAT6 numero di spot: Synonyms: Gamma interferone stimolato da Mycobacterium tuber Interferone gamma stimolato da microbatterio della Micobatterio della tubercolosi Microbiologia Numero (conta) Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | Mycobacterium tuberculosis-gestimuleerde gamma-interferon ESAT-6-Ag spot count: |
pl-PL | Polish (Poland) | Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag ESAT-6: Synonyms: Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag ESAT-6 |
pt-BR | Portuguese (Brazil) | Mycobacterium tuberculosis estimulada gama interferon.ESAT-6 Ag contagem de ponto: |
ru-RU | Russian (Russian Federation) | Mycobacterium tuberculosis стимулированный гамма интерферон.ESAT-6 Аг пятно количество панель: Synonyms: Количественный Количество Кровь Точка во времени; |
tr-TR | Turkish (Turkey) | Mycobacterium tuberculosis uyarılmış gamma interferon.ESAT-6 Ag spot sayım: |
zh-CN | Chinese (China) | 结核分枝杆菌刺激型 gamma 干扰素.ESAT-6 抗原斑点计数: Synonyms: AFB IFN 个数; |
Example Units
Unit | Source |
---|---|
{#} | Example UCUM Units |
74277-5 Mycobacterium tuberculosis stimulated gamma interferon CFP10 Ag spot count [#] in Blood
Term Description
The count of spots (0 to >20) in a patient's T cells that represent IFN-γ released in response to the presence of M. tuberculosis culture filtrate protein 10 (CFP10) antigens. The spot count provides a measurement of the abundance of Mycobacterium tuberculosis sensitive effector T cells in the peripheral blood. This term is based on, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT.TB assay, the test result is positive if [ESAT-6 (Panel A) - negative control spots] and/or [CFP10 (Panel B) - negative control spots] is greater than or equal to 8 spots. The test result is negative if both [Panel A - negative control] and/or [Panel B - negative control] is less than or equal to 4 spots.
Part Descriptions
LP173644-8 Mycobacterium tuberculosis stimulated gamma interferon.CFP10 Ag spot count
CFP10, also known as ESAT-6-like protein esxB, is a protein that is encoded by the esxB gene. CFP10 is a 10 kDa secreted antigen from Mycobacterium tuberculosis. It forms a 1:1 heterodimeric complex with ESAT-6. Both genes are expressed from the RD1 region of the bacterial genome and play a key role in the virulence of the infection. It is used in tuberculosis diagnosis by whole blood interferon γ tests, e.g. QuantiFERON-TB Gold and T-SPOT.TB, in conjunction with ESAT-6 and TB7.7 (QuantiFERON-TB Gold).
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, CFP10
Fully-Specified Name
- Component
- Mycobacterium tuberculosis stimulated gamma interferon.CFP10 Ag spot count
- Property
- Num
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.64 (MIN)
- Order vs. Observation
- Both
Formula (Readable)
Total Panel B (CFP-10 Ag) spot count = Panel B (CFP-10 Ag) spot count - Negative control spot count
Member of these Panels
LOINC | Long Common Name |
---|---|
74281-7 | Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου CFP10: Synonyms: Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Αρ. Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου CFP10 Ιντερφερόνη |
es-ES | Spanish (Spain) | Mycobacterium tuberculosis estimulado con interferón gamma antígeno CFP10 recuento de manchas: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Interferón gamma estimulado por Mycobacterium tuberculosis.CFP10 Ag spot count: |
fr-FR | French (France) | Interféron gamma stimulé par mycobacterium tuberculosis antigène CFP10 spots comptés: |
it-IT | Italian (Italy) | Interferone gamma stimolato da bacillo di Koch.Antigeni CFP10 numero di spot: Synonyms: Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Numero (conta) Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | Mycobacterium tuberculosis-gestimuleerde gamma-interferon CFP10-Ag spot count: |
pl-PL | Polish (Poland) | Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag CFP10: Synonyms: Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag CFP10 |
pt-BR | Portuguese (Brazil) | Mycobacterium tuberculosis estimulada gama interferon.CFP10 Ag contagem de ponto: |
ru-RU | Russian (Russian Federation) | Mycobacterium tuberculosis стимулированный гамма интерферон.CFP10 Аг пятно количество панель: Synonyms: Количественный Количество Кровь Точка во времени; |
tr-TR | Turkish (Turkey) | Mycobacterium tuberculosis uyarılmış gamma interferon.CFP10 Ag spot sayım: |
zh-CN | Chinese (China) | 结核分枝杆菌刺激型 gamma 干扰素.CFP10 抗原斑点计数: Synonyms: AFB IFN 个数; |
Example Units
Unit | Source |
---|---|
{#} | Example UCUM Units |
71773-6 Mycobacterium tuberculosis stimulated gamma interferon [Interpretation] in Blood Qualitative
Part Descriptions
LP149676-1 Mycobacterium tuberculosis stimulated gamma interferon
Interferon-γ (interferon-gamma) release assays (IGRAs) are based on the ability of the Mycobacterium tuberculosis antigens for early secretory antigen target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) to stimulate host production of interferon-gamma. Because these antigens are not present in non-tuberculous mycobacteria or in any BCG vaccine variant, these tests can distinguish latent tuberculosis infection (LTBI). The blood tests QuantiFERON-TB Gold In-Tube and T-SPOT.TB use these antigens to detect people with tuberculosis. Lymphocytes from the patient's blood are incubated with the antigens. If the patient has been exposed to tuberculosis before, T lymphocytes produce interferon γ in response. These tests are both interferon γ tests but they are not equivalent. The QuantiFERON-TB Gold In-Tube uses an ELISA format to quantify the total amount of interferon γ when whole blood is exposed to the antigens (ESAT-6,CFP-10 and TB 7.7). T-SPOT.TB is a type of enzyme-linked immunospot assay (ELISPOT) assay, which counts the number of activated T lymphocytes that secrete interferon γ.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Mycobacterium tuberculosis stimulated gamma interferon
- Property
- Imp
- Time
- Pt
- System
- Bld
- Scale
- Ord
- Method
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.40
- Last Updated
- Version 2.73 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Property from 'PrThr' to 'Imp' since the result for this observation is the overall interpretation of the assay.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 451
Example Answer List LL759-2
Answer | Code | Score | Answer ID |
---|---|---|---|
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
Indeterminate Copyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) | LA11884-6 |
Member of these Panels
LOINC | Long Common Name |
---|---|
74281-7 | Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood |
71775-1 | Mycobacterium tuberculosis stimulated gamma interferon panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
de-DE | German (Germany) | Mycobacterium tuberculosis stimuliertes Gamma-Interferon: |
el-GR | Greek (Greece) | Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη: Synonyms: Imp Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη Ιντερφερόνη |
es-MX | Spanish (Mexico) | Interferón gamma estimulado por Mycobacterium tuberculosis: |
es-ES | Spanish (Spain) | Mycobacterium tuberculosis estimulado con interferón gamma: |
fr-BE | French (Belgium) | Mycobacterium tuberculosis, stimulation par gamma Interféron: Synonyms: IF |
fr-FR | French (France) | Interféron gamma stimulé par mycobacterium tuberculosis: |
fr-CA | French (Canada) | Mycobacterium tuberculosis, stimulation par le gamma Interféron: |
it-IT | Italian (Italy) | Mycobacterium tuberculosis, gamma interferone stimolato: Synonyms: Gamma interferone stimolato da Mycobacterium tuber Impressione/interpretazione di studio Micobatterio della tubercolosi Microbiologia Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | Mycobacterium tuberculosis gestimuleerd gamma-interferon: |
pt-BR | Portuguese (Brazil) | Mycobacterium tuberculosis gama interferon estimulada: |
ru-RU | Russian (Russian Federation) | Mycobacterium tuberculosis стимулированный гамма интерферон: Synonyms: Впечатление/интерпретация исследования Кровь Порядковый Точка во времени; |
tr-TR | Turkish (Turkey) | Mycobacterium tuberculosis indüklenmiş gamma interferon: |
zh-CN | Chinese (China) | 结核分枝杆菌刺激型 gamma 干扰素: Synonyms: AFB IFN 依次型; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
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