74371-6

Cotinine [Mass/volume] in Saliva (oral fluid) by Confirmatory method

Active

Part Descriptions

LP14564-6   Cotinine
The N-glucuronide conjugate of cotinine is a major urinary metabolite of nicotine. It serves as a biomarker of exposure to tobacco. It stimulates the CNS. Source: National Library of Medicine, MeSH 2006

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583 Source: Regenstrief LOINC

Fully-Specified Name

Component

Cotinine

Property

MCnc

Time

Pt

System

Saliva

Scale

Qn

Method

Confirm

Additional Names

Short Name

Cotinine Sal Cfm-mCnc

Display Name

Cotinine Confirm (Sal) [Mass/Vol]

Consumer Name Alpha Get Info

Cotinine, Saliva

Associated Observations

Related Codes

Basic Attributes

Class

DRUG/TOX

Type

Laboratory

First Released

Version 2.46

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

5440

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Cfm
• CNFR
• CNFRM
• Conf
• Confirmation
• Confirmatory
• DRUG/TOXICOLOGY
• Drugs
• GCMS
• LC/MS/MS
• Level
• Mass concentration
• Nicotine metabolite
• Oral fluid
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Sal

Example Units

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