74858-2

Hepatitis E virus genotypes 1+2+3+4 RNA [Presence] in Serum or Plasma from Donor by NAA with probe detection

Active

Term Description

An in vitro nucleic acid amplification assay for the direct qualitative detection of hepatitis E virus (HEV) genotypes 1-4 RNA in human plasma or serum. This is a blood screening assay to detect HEV RNA. Plasma from whole blood, blood components, or collections by apheresis can also be used. Plasma from all donors or manufacturing pools may be tested as separate specimens or in pools composed of aliquots of individual specimens. This assay is not meant for use on cord blood nor for use as an aid in diagnosis. This term was created for, but not limited in use to, the Cobas® HEV assay.

Part Description

LP183572-9 Hepatitis E virus genotypes 1+2+3+4 RNA
Hepatitis E virus (HEV) is a small, non-enveloped, single-stranded RNA virus. There are four major HEV genotypes (genotypes 1 to 4) that comprise a single serotype. Genotypes 1, 2 and 4 are associated with widespread outbreaks and are found in Asia and Africa, Mexico and west Africa, and Taiwan and China, respectively. Genotype 3 is the cause of isolated cases in developed countries. HEV infection targets the liver and is usually a self-limited, acute illness in immunocompetent patients, however, patients with solid organ transplants who are infected with HEV may develop chronic hepatitis. In developing countries, the most common source of HEV is fecally-contaminated drinking water. In developed countries, sporadic cases of HEV genotype 3 have occurred following consumption of uncooked or undercooked pork or deer meat and consumption of shellfish; zoonotic spread is possible though not common. As of 2015, there is no FDA-approved vaccine for HEV in the U.S., but a recombinant vaccine was recently approved for use in China. [CDC: hepatitis/hev/hevfaq.htm] Source: Regenstrief LOINC, CDC: Hepatitis E Virus

LOINC Names Get Info

Fully-Specified Name: Hepatitis E virus genotypes 1+2+3+4 RNA:PrThr:Pt:Ser/Plas^Donor:Ord:Probe.amp.tar
Long Common Name: Hepatitis E virus genotypes 1+2+3+4 RNA [Presence] in Serum or Plasma from Donor by NAA with probe detection
Short Name: HEV 1+2+3+4 RNA SerPl Donr Ql NAA+probe
Display Name: HEV genotypes 1+2+3+4 RNA NAA+probe Ql (S/P donor)
Consumer Name Alpha Get Info: HEV genotypes 1+2+3+4, Donor Blood

Part Model Get Info

Component
Hepatitis E virus genotypes 1+2+3+4 RNA
LP183572-9
- Analyte
  Hepatitis E virus genotypes 1+2+3+4 RNA
  LP183572-9
  - Component Numerator
    Hepatitis E virus genotypes 1+2+3+4 RNA
    LP183572-9
    - Component Numerator Core
      Hepatitis E virus genotypes 1+2+3+4
      LP183578-6
    - Component Numerator Core Suffix
      RNA
      LP32423-3
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas^Donor
LP30269-2
- System Core
  Ser/Plas
  LP7576-4
- Super System
  Donor
  LP7742-2
Scale
Ord
LP7751-3
Method
Probe.amp.tar
LP6464-4

Example Answer List: LL2888-7

Source: Roche Diagnostics International

Answer	Code	Score	Answer ID
NonreactiveCopyright http://snomed.info/sct ID:131194007 Non-reactive (qualifier value)			LA15256-3
ReactiveCopyright http://snomed.info/sct ID:11214006 Reactive (qualifier value)			LA15255-5
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value)			LA15841-2

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.63 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus hepatitidy E genotypy 1+2+3+4 RNA:Přítomnost nebo práh:Časový bod:Sérum/plazma^Dárce:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
de-DE	German (Germany)	Hepatitis-E-Virus Genotypen 1+2+3+4 RNA:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma^Donor:Ordinal:Zielfragmentamplifikation mit Sondendetektion
el-GR	Greek (Greece)	Ιός ηπατίτιδας Ε, γονότυποι 1+2+3+4 RNA:PrThr:Pt:Ορός/Πλάσμα^Δότης:Ord:Ανιχνευτής.ενίσχυση.στόχου Synonyms: E MICRO Ord PrThr Pt RNA Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Δότης Ιός Ιός ηπατίτιδας Ε Ιός ηπατίτιδας Ε, γονότυποι 1+2+3+4 Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Virus de la hepatitis E genotipos 1+2+3+4 RNA:PrThr:Punto temporal:Suero o Plasma^donante:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	Genotipos 1 + 2 + 3 + 4 del virus de la hepatitis E ARN:Presencia o umbral:Punto temporal:Suero o plasma ^ Donante:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Hépatite E virus génotypes 1+2+3+4 ARN:Présence/Seuil:Ponctuel:Sérum/Plasma^donneur:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Epatite E virus, genotipi 1+2+3+4 RNA:PrThr:Pt:Siero/Plasma^donatore:Ord:Sonda.amp.tar Synonyms: Microbiologia Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Siero o Plasma^Donatore Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus dell''epatite E
nl-NL	Dutch (Netherlands)	Hepatitis E-virus genotypes 1+2+3+4 RNA:aanwezigheid:moment:serum of plasma^donor:ordinaal:probe-detectie Synonyms: probe.amp.tar
pl-PL	Polish (Poland)	Genotyp 1+2+3+4 wirusa zapalenia wątroby typu E RNA:granica wykrywalności:punkt w czasie:surowica lub osocze^dawca:uporządkowany:sonda.amplifikacja.cel Synonyms: amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy RNA wirusa zapalenia wątroby typu E genotypów 1+2+3+4
ru-RU	Russian (Russian Federation)	Гепатит E вирус генотипы 1+2+3+4 РНК:PrThr:ТчкВрм:Сыв/Плаз^донор:Пор:Проба.усил.миш Synonyms: ДНК проба;ДНК зонд Плазма Порядковый Проба с мишени усилением Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	Hepatitis E virüs genotypes 1+2+3+4 RNA:MevcEşik:Zmlı:Ser/Plaz^verici:Srl:Prob.amf.hdf Synonyms: Mevcut
zh-CN	Chinese (China)	戊型肝炎病毒基因型 1+2+3+4 RNA:存在情况或阈值:时间点:血清/血浆^供体:序数型:探针法.基因扩增.靶向 Synonyms: Ⅰ Ⅱ Ⅲ E 型 Hep E;HEV;戊型肝炎;戊肝;戊肝病毒;肝炎病毒 E 型 I II III 三传染性肝炎传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体供血者;捐献者;捐赠者;给予体;给体;超系统 - 供体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向叁存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）戊肝病毒基因型 1+2+3+4;肝炎病毒 E 型基因型 1+2+3+4 扩增型扩增性时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 经过扩增的肝脱氧核糖核酸探针血清/血浆^捐赠者血清或血浆

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74858-2

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.