Version 2.78

Term Description

The average number of fluorescent signals targeting the ERBB2 gene (HER2 locus) in nuclei are determined in order to calculate the average ratio of ERBB2 gene to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals along with CEP17 signals [LOINC: 74861-6] are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene amplification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00.
Source: Regenstrief LOINC

Part Descriptions

LP182376-6   ERBB2 gene copy number
HER2/neu (also known as ErbB-2) stands for "Human Epidermal growth factor Receptor 2" and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2/neu has also been designated as CD340 (cluster of differentiation 340) and p185. It is encoded by the ERBB2 gene. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
ERBB2 gene copy number/nucleus
Property
EntNum
Time
Pt
System
Tiss
Scale
Qn
Method
FISH

Additional Names

Short Name
ERBB2 copy num/nucleus EntNum Tiss FISH
Display Name
ERBB2 copy number/nucleus FISH (Tiss) [Entitic number]
Consumer Name Alpha Get Info
ERBB2 copy number/nucleus, Tissue

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.73
Change Reason
Release 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor.; Previous Releases: Updated "signals" in Component to "copy number" to align with current nomenclature and similar terms
Order vs. Observation
Observation
Common Test Rank Get Info
9860

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols
74885-5 ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Señales HER2/núcleo:Número entítico:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH)
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Número de copia / núcleo del gen HER2:Número entitic:Punto temporal:Tejido y frotis:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR French (France) HER2 gène nombre de copie/noyaux:Nombre/entité:Ponctuel:Tissu:Numérique:FISH
it-IT Italian (Italy) ERBB2,numero copia del gene/nucleo:EntNum:Pt:Tessuto:Qn:FISH
Synonyms: Gene ERBB2 Ibridazione in situ fluorescente (FISH) Numero entitico Patologia molecolare Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) aantal kopieën van ERBB2-gen/kern:aantal/eenheid:moment:weefsel en uitstrijkjes:kwantitatief:FISH
Synonyms: ERBB2 gen HER2 nucleus
pt-BR Portuguese (Brazil) HER2 sinais/núcleo::Pt:Tecido:Qn:FISH
tr-TR Turkish (Turkey) HER2 sinyallaeri/çekirdek:EntSay:Zmlı:Doku:Kant:FISH
zh-CN Chinese (China) HER2 基因拷贝数/核:实体数量:时间点:组织与涂片:定量型:FISH
Synonyms: c-erb B2;Her2;HER-2/neu;NGL;TKR1;V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/恶性胶质瘤源性癌基因同源基因);V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/恶性胶质瘤源性致癌基因同源基因);V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/成胶质细胞瘤源性癌基因同源基因);V-ERB-B2 禽类成红血细胞性白血病病毒性致癌基因同源基因 2 (神经/成胶质细胞瘤源性致癌基因同源基因);V- Fluorescent in situ hybridization;荧光原位杂交 HER2 基因拷贝（副本）数（数量、计数）;HER2 信号 个数;数目 分子病理学;分子病理学试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 实体计数 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 细胞核 遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit Source
{#} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74860-8