74885-5
ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH
Active
31150-6 ERBB2 gene duplication [Presence] in Tissue by FISH
Part Descriptions
LP36215-9 ERBB2 gene
The ERBB2 gene (erb-b2 receptor tyrosine kinase 2) [HGNC Gene ID:3430] is located on chromosome 17q12. This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] [NCBI Gene ID:2064]
Source: National Center for Biotechnology Information (NCBI) Gene
LP422046-5 ERBB2 gene duplication
The ERBB2 (erb-b2 receptor tyrosine kinase 2) gene is an oncogene that encodes the HER-2 (human epidermal growth factor receptor 2) receptor, commonly called HER2/neu. HER-2 is a member of the human epidermal growth factor receptor (EGFR) family. Amplification (gene duplication) leading to over-expression of this oncogene is associated with various types of aggressive cancers, including breast and gastric cancers. Detection of gene amplification in tumor specimens by fluorescent in situ hybridization (FISH) is considered the gold standard for HER-2 testing. PMID: 19204209
Source: Regenstrief LOINC
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, FISH
Fully-Specified Name
- Component
- ERBB2 gene duplication
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- FISH
Additional Names
- Short Name
- ERBB2 gene Dp Tiss Ql FISH
- Display Name
- ERBB2 gene dup FISH Ql (Tiss)
- Consumer Name Alpha Get Info
- ERBB2 gene duplication analysis, Tissue
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.07
- Last Updated
- Version 2.73
- Change Reason
- Release 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor. Also added "gene duplication" since this test is detecting the presence or absence of the amplified/duplicated gene.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 9391
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74885-5 | ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | HER2: |
| es-ES | Spanish (Spain) | Gen ERBB2 Duplicación: |
| es-AR | Spanish (Argentina) | HER2: |
| et-EE | Estonian (Estonia) | ERBB2 geen duplikatsioon: Synonyms: Järgarvuline Juhuslik Kude |
| fr-FR | French (France) | ERBB2 gène duplication: |
| it-IT | Italian (Italy) | ERBB2, gene, duplicazione: Synonyms: Gene ERBB2 Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | ERBB2-gen duplicatie: Synonyms: ERBB2 gen |
| pt-BR | Portuguese (Brazil) | HER2: Synonyms: HER-2/neu; |
| tr-TR | Turkish (Turkey) | ERBB2 geni dublikasyon: Synonyms: çiftleme Mevcut |
| zh-CN | Chinese (China) | ERBB2 基因 复制: Synonyms: c-erb B2; |
49683-6 ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH
Term Description
The ratio of HER-2/neu (ERBB2 gene) to CEP17 probes by in situ hybridization assays (e.g. FISH) to determine overexpression of HER-2/neu protein in breast cancer. CEP17 is used as an internal control and to account for aneusomy (varying number) of chromosome 17. A ratio of >2.0 indicates gene amplification and overexpression of HER-2/neu according to the 2013 ASCO-CAP HER2 test guideline recommendations. Results are used to assist in dose selection for certain drugs, assess eligibility for trastuzumab (Herceptin®) treatment, predict response to drug therapies and overall survival in patients with breast cancer. For testing without an internal control probe, see LOINCs 31150-6 and 48675-3. For determining HER-2 status by Immunohistochemistry (IHC), see LOINC 18474-7.
Source: Regenstrief LOINC
Part Descriptions
LP182376-6 ERBB2 gene copy number
HER2/neu (also known as ErbB-2) stands for "Human Epidermal growth factor Receptor 2" and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2/neu has also been designated as CD340 (cluster of differentiation 340) and p185. It is encoded by the ERBB2 gene.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, FISH
Fully-Specified Name
- Component
- ERBB2 gene copy number/Chromosome 17 copy number
- Property
- NRto
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- FISH
Additional Names
- Short Name
- ERBB2 copy num/Chr 17 copy num Tiss FISH
- Display Name
- ERBB2 copy number/Chromosome 17 copy number FISH (Tiss) [# ratio]
- Consumer Name Alpha Get Info
- ERBB2 copy number/Chromosome 17 copy number, Tissue
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.22
- Last Updated
- Version 2.73
- Change Reason
- Release 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor.; Previous Releases: Updated Component from "HER2/CEP17" and Property from "Ratio" to align with current nomenclature and similar terms
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 7211
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 85904-1 | Cancer pathology panel - Breast cancer specimen by CAP cancer protocols |
| 74885-5 | ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Señales HER2/CEP17: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Número de copia del gen HER2 / Número de copia del cromosoma 17: |
| fr-FR | French (France) | HER2 gène/chromosome 17 nombre de copie: |
| fr-CA | French (Canada) | ERBB2 gène duplication/Nombre de copie du chromosome 17: |
| it-IT | Italian (Italy) | ERBB2,numero copia del gene/CEP17: Synonyms: Gene ERBB2 Ibridazione in situ fluorescente (FISH) Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Tessuto & |
| nl-NL | Dutch (Netherlands) | aantal kopieën van ERBB2-gen/aantal centromeren van chromosoom 17: Synonyms: CEP17 ERBB2 gen HER2 |
| pt-BR | Portuguese (Brazil) | HER2/CEP17: Synonyms: HER-2/neu; |
| tr-TR | Turkish (Turkey) | HER2 sinyallaeri/CEP17: |
| zh-CN | Chinese (China) | HER2 基因拷贝数/染色体 17 拷贝数: Synonyms: c-erb B2; |
74860-8 ERBB2 gene copy number/nucleus in Tissue by FISH
Term Description
The average number of fluorescent signals targeting the ERBB2 gene (HER2 locus) in nuclei are determined in order to calculate the average ratio of ERBB2 gene to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals along with CEP17 signals [LOINC: 74861-6] are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene amplification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00.
Source: Regenstrief LOINC
Part Descriptions
LP182376-6 ERBB2 gene copy number
HER2/neu (also known as ErbB-2) stands for "Human Epidermal growth factor Receptor 2" and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2/neu has also been designated as CD340 (cluster of differentiation 340) and p185. It is encoded by the ERBB2 gene.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, FISH
Fully-Specified Name
- Component
- ERBB2 gene copy number/nucleus
- Property
- EntNum
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- FISH
Additional Names
- Short Name
- ERBB2 copy num/nucleus EntNum Tiss FISH
- Display Name
- ERBB2 copy number/nucleus FISH (Tiss) [Entitic number]
- Consumer Name Alpha Get Info
- ERBB2 copy number/nucleus, Tissue
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.73
- Change Reason
- Release 2.70: COMPONENT: Corrected the gene name based on the LOINC model to use the approved HGNC name for the gene that encodes the HER2 receptor.; Previous Releases: Updated "signals" in Component to "copy number" to align with current nomenclature and similar terms
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 9860
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 85904-1 | Cancer pathology panel - Breast cancer specimen by CAP cancer protocols |
| 74885-5 | ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Señales HER2/núcleo: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Número de copia / núcleo del gen HER2: |
| fr-FR | French (France) | HER2 gène nombre de copie/noyaux: |
| it-IT | Italian (Italy) | ERBB2,numero copia del gene/nucleo: Synonyms: Gene ERBB2 Ibridazione in situ fluorescente (FISH) Numero entitico Patologia molecolare Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | aantal kopieën van ERBB2-gen/kern: Synonyms: ERBB2 gen HER2 nucleus |
| pt-BR | Portuguese (Brazil) | HER2 sinais/núcleo: |
| tr-TR | Turkish (Turkey) | HER2 sinyallaeri/çekirdek: |
| zh-CN | Chinese (China) | HER2 基因拷贝数/核: Synonyms: c-erb B2; |
Example Units
| Unit | Source |
|---|---|
| {#} | Example UCUM Units |
74861-6 Chromosome 17 copy number/nucleus in Tissue by FISH
Term Description
The average number of Chromosome 17 fluorescent signals in nuclei are determined in order to calculate the average ratio of HER2 to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene (HER2 locus) via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals [LOINC: 74860-8] along with CEP17 signals are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene applification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00.
Source: Regenstrief LOINC
Part Descriptions
LP182348-5 Chromosome 17 copy number
The Chromosome 17 DNA probe marks the centromeric region of chromosome 17 and is used as an internal control and to account for aneusomy (varying number) of chromosome 17.
Source: Regenstrief LOINC
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, FISH
Fully-Specified Name
- Component
- Chromosome 17 copy number/nucleus
- Property
- EntNum
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- FISH
Additional Names
- Short Name
- Chr 17 copy num/nucleus EntNum Tiss FISH
- Display Name
- Chromosome 17 copy number/nucleus FISH (Tiss) [Entitic number]
- Consumer Name Alpha Get Info
- Chromosome 17 copy number/nucleus, Tissue
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.73
- Change Reason
- Updated Component from "CEP17 signals" to "Chromosome 17 copy number" to align with current nomenclature and similar terms
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 11691
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 85904-1 | Cancer pathology panel - Breast cancer specimen by CAP cancer protocols |
| 74885-5 | ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Señales de CEP17/núcleo: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Número de copias / núcleo del cromosoma 17: |
| fr-FR | French (France) | Chromosome 17 nombre de copie/noyaux: |
| it-IT | Italian (Italy) | CEP17, segnali/nucleo: Synonyms: Ibridazione in situ fluorescente (FISH) Numero entitico Patologia molecolare Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | aantal centromeren van chromosoom 17/kern: Synonyms: CEP17 nucleus |
| pl-PL | Polish (Poland) | Liczba kopii chromosomu 17/jądro: |
| pt-BR | Portuguese (Brazil) | CEP17 sinais/núcleo: |
| tr-TR | Turkish (Turkey) | CEP17 sinyalleri/çekirdek: |
| zh-CN | Chinese (China) | 染色体 17 拷贝数/核: Synonyms: Fluorescent in situ hybridization; |
Example Units
| Unit | Source |
|---|---|
| {#} | Example UCUM Units |
62361-1 Cells counted [#]
Term Description
The number of metaphase cells evaluated for chromosome number.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cells counted
- Property
- Num
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Qn
- Method
- Molgen
Additional Names
- Short Name
- Cells counted
- Display Name
- Cells counted Molgen (Bld/Tiss) [#]
- Consumer Name Alpha Get Info
- Cells counted, Blood or tissue specimen
Basic Attributes
- Class
- HL7.CYTOGEN
- Type
- Laboratory
- First Released
- Version 2.34
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 3727
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 62389-2 | Chromosome analysis master panel |
| 74885-5 | ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Recuento celular: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Células contadas: |
| fr-FR | French (France) | Cellules comptées: |
| it-IT | Italian (Italy) | Cellule contate: Synonyms: Genetica molecolare Numero (conta) Punto nel tempo (episodio) Referto clinico di citogenetica Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | cellen geteld: Synonyms: molgen |
| pl-PL | Polish (Poland) | Zliczone komórki: |
| ru-RU | Russian (Russian Federation) | Клетки подсчитанные: Synonyms: Количественный Количество Кровь Кровь или Ткань Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | Hücreler sayılan: |
| zh-CN | Chinese (China) | 已计数的细胞: Synonyms: HL7 细胞遗传学 个数; |
Example Units
| Unit | Source |
|---|---|
| {#} | Example UCUM Units |
19147-8 Referral lab test reference range
Fully-Specified Name
- Component
- Referral lab test reference range
- Property
- Find
- Time
- Pt
- System
- Referral lab test
- Scale
- Nom
- Method
Additional Names
- Short Name
- Ref Lab Test Ref Range
- Display Name
- Referral lab test reference range
- Consumer Name Alpha Get Info
- Referral lab test reference range
Basic Attributes
- Class
- MISC
- Type
- Laboratory
- First Released
- Version 1.0l
- Last Updated
- Version 2.73
- Change Reason
- Release 2.70: COMPONENT: Updated "Reference" to "Referral" to broaden use and apply to any referral lab, not just reference labs.; Previous Releases: Corrected Timing from "XXX" to "Pt"
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 645
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74885-5 | ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH |
| 51991-8 | Referral lab test panel |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Rango de referencia de las pruebas de laboratorio de referencia: |
| es-MX | Spanish (Mexico) | Rango de referencia de prueba de laboratorio de referencia: |
| es-AR | Spanish (Argentina) | rango de referencia de la prueba de laboratorio de referencia: |
| fr-FR | French (France) | Normes du test de laboratoire de référence: |
| it-IT | Italian (Italy) | Laboratorio di riferimento, intervallo di riferimento del test: Synonyms: Intervallo di riferimento del test del laboratorio di riferimento Miscellanea Osservazione Punto nel tempo (episodio) Test del laboratorio di riferimento |
| nl-NL | Dutch (Netherlands) | verwijzingslaboratorium referentie-interval: |
| pt-BR | Portuguese (Brazil) | Valores de referência do teste no laboratório de referência: Synonyms: ; |
| zh-CN | Chinese (China) | 受托实验室检验项目参考范围: Synonyms: 分类型应答; |