74945-7

clomiPRAMINE+Norclomipramine [Mass/volume] in Serum or Plasma --trough

Active

Term Description

Clomipramine and its metabolite, norclomipramine, are measured to monitor therapeutic drug levels and evaluate toxicity of clomipramine, a tricyclic antidepressant used primarily to treat obsessive-compulsive disorders, panic disorders and depression. The sample is drawn at the parent drug trough level.

Part Descriptions

LP16084-3 clomiPRAMINE+Norclomipramine
A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine. Source: National Library of Medicine, MeSH 2006

LP16084-3 clomiPRAMINE+Norclomipramine
Norclomipramine is a main metabolite of clomipramine. Source: Regenstrief LOINC

LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Trough levels for therapeutic drug monitoring

LOINC Names Get Info

Fully-Specified Name: clomiPRAMINE+Norclomipramine^trough:MCnc:Pt:Ser/Plas:Qn:
Long Common Name: clomiPRAMINE+Norclomipramine [Mass/volume] in Serum or Plasma --trough
Short Name: clomiPRAMINE+Nor Trough SerPl-mCnc
Display Name: clomiPRAMINE+Norclomipramine trough [Mass/Vol]
Consumer Name Alpha Get Info: clomiPRAMINE+Norclomipramine trough, Blood

Part Model Get Info

Component
Clomipramine+Norclomipramine^trough
LP307872-4
- Analyte
  clomiPRAMINE+Norclomipramine
  LP16084-3
  - Component Numerator
    clomiPRAMINE+Norclomipramine
    LP16084-3
    - Component Numerator Core
      clomiPRAMINE+Norclomipramine
      LP16084-3
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  trough
  LP20176-1
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.69 (MIN)
Change Reason: Release 2.69: COMPONENT: Added TALLMAN lettering;
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
77374-7	clomiPRAMINE trough, clomiPRAMINE+Norclomipramine trough and Norclomipramine panel - Serum or Plasma

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Klomipramin+norklomipramin^Údolní koncentrace:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
el-GR	Greek (Greece)	Κλομιπραμίνη+Νορκλομιπραμίνη^ελάχιστα επίπεδα:MCnc:Pt:Ορός/Πλάσμα:Qn: Synonyms: DRUG/TOX MCnc Pt Qn ελάχιστα επίπεδα Κλομιπραμίνη Κλομιπραμίνη+Νορκλομιπραμίνη Νορκλομιπραμίνη Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Clomipramina + Norclomipramina^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Suero o Plasma:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Clomipramina + Norclomipramina ^ a través:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE	Estonian (Estonia)	Klomipramiin + norklomipramiin^baas:MCnc:Pt:S/P:Qn: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA	French (Canada)	Clomipramine+norclomipramine^Creux:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR	French (France)	Clomipramine+norclomipramine^taux résiduel:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE	French (Belgium)	Clomipramine+norclomipramine^Creux:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif: Synonyms: Minimum, nadir
it-IT	Italian (Italy)	Clomipramina+Norclomipramina^valore minimo:MCnc:Pt:Siero/Plasma:Qn: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM
nl-NL	Dutch (Netherlands)	clomipramine + norclomipramine^dalspiegel:massa/volume:moment:serum of plasma:kwantitatief:
ru-RU	Russian (Russian Federation)	Кломипрамин+Норкломипрамин^остаточная концентрация:МассКонц:ТчкВрм:Сыв/Плаз:Колич: Synonyms: Количественный Массовая концентрация минимум концентрации Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR	Turkish (Turkey)	Klomipramin+NorKlomipramin^en düşük:KütlKons:Zmlı:Ser/Plaz:Kant: Synonyms: çukur düzey
zh-CN	Chinese (China)	氯米帕明+去甲基氯米帕明^波谷:质量浓度:时间点:血清/血浆:定量型: Synonyms: 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 脱甲基氯米帕明;去甲氯米帕明;氯米帕明代谢产物药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
ug/L	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74945-7

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.