75132-1
Oxipurinol/Creatinine [Molar ratio] in Urine
Active
Part Descriptions
LP18483-5 Oxipurinol
Oxypurinol is an inhibitor of xanthine oxidase. It is an active metabolite of allopurinol and it is cleared renally. In cases of renal disease, this metabolite will accumulate to toxic levels.
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Source: Wikipedia, Oxypurinol
LP18483-5 Oxipurinol
Oxipurinol [alloxanthine, Oxyprim, oxypurinol] is the active metabolite of the only commercially available xanthine oxidase inhibitor, allopurinol. Oxipurinol is also a xanthine oxidase inhibitor. Oxipurinol is currently being developed by Cardiome Pharma. It is waiting for approval in the US for the treatment of allopurinol-intolerant hyperuricaemia (gout) and is in phase III trials for the treatment of congestive heart failure. Allopurinol is indicated for the treatment of symptomatic hyperuricaemia, or gout. Approximately 3-5% of patients receiving allopurinol develop intolerance to the drug. Oxipurinol was originally developed by Burroughs Wellcome (later GlaxoSmithKline), and has been available on a compassionate-use basis since 1967 for use in allopurinol-intolerant patients. The licensee company ILEX Oncology has stated that oxipurinol does not have patent protection. Oxipurinol's potential for treatment of congestive heart failure is based on the possibility that xanthine oxidase inhibitors may improve myocardial work efficiency by sensitising cardiac muscle cells to calcium ions, which are a key determinant of cardiac muscle function. This results in more efficient contraction of cardiac muscle cells, without the same increase in oxygen demand. At the second annual BioPartnering North America conference (BPN-2004) [February 2004, Vancouver, Canada], Cardiome Pharma stated that it was seeking a commercialisation partner to market and distribute oxipurinol in the US for the treatment of allopurinol-intolerant hyperuricaemia. [Drugs R D. 2004;5(3):171-5.]
Source: NCBI PubMed, PMID:15139781
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- Oxipurinol/Creatinine
- Property
- SRto
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Short Name
- Oxipurinol/Creat Ur-sRto
- Display Name
- Oxipurinol/Creatinine (U) [Molar ratio]
- Consumer Name Alpha Get Info
- Oxipurinol/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.54
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 79673-0 | Purine and Pyrimidine panel - Urine |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Oxipurinol/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Oxipurinol / Creatinina: |
| fr-CA | French (Canada) | Oxipurinol/Créatinine: |
| fr-FR | French (France) | Oxipurinol/créatinine: |
| fr-BE | French (Belgium) | Oxipurinol/Créatinine: |
| it-IT | Italian (Italy) | Ossipurinolo/Creatinina: Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza |
| nl-NL | Dutch (Netherlands) | oxipurinol/creatinine: Synonyms: kreatinine |
| pt-BR | Portuguese (Brazil) | Oxipurinol/Creatinina: |
| ru-RU | Russian (Russian Federation) | Оксипуринол/Креатинин: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Oksipürinol/Kreatinin: Synonyms: SubsOranı |
| zh-CN | Chinese (China) | 奥昔嘌醇/肌酐: Synonyms: CR; |
Example Units
| Unit | Source |
|---|---|
| umol/mmol{creat} | Example UCUM Units |
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