75132-1

Oxipurinol/Creatinine [Molar ratio] in Urine

Active

Part Descriptions

LP18483-5   Oxipurinol
Oxypurinol is an inhibitor of xanthine oxidase. It is an active metabolite of allopurinol and it is cleared renally. In cases of renal disease, this metabolite will accumulate to toxic levels. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Oxypurinol

LP18483-5   Oxipurinol
Oxipurinol [alloxanthine, Oxyprim, oxypurinol] is the active metabolite of the only commercially available xanthine oxidase inhibitor, allopurinol. Oxipurinol is also a xanthine oxidase inhibitor. Oxipurinol is currently being developed by Cardiome Pharma. It is waiting for approval in the US for the treatment of allopurinol-intolerant hyperuricaemia (gout) and is in phase III trials for the treatment of congestive heart failure. Allopurinol is indicated for the treatment of symptomatic hyperuricaemia, or gout. Approximately 3-5% of patients receiving allopurinol develop intolerance to the drug. Oxipurinol was originally developed by Burroughs Wellcome (later GlaxoSmithKline), and has been available on a compassionate-use basis since 1967 for use in allopurinol-intolerant patients. The licensee company ILEX Oncology has stated that oxipurinol does not have patent protection. Oxipurinol's potential for treatment of congestive heart failure is based on the possibility that xanthine oxidase inhibitors may improve myocardial work efficiency by sensitising cardiac muscle cells to calcium ions, which are a key determinant of cardiac muscle function. This results in more efficient contraction of cardiac muscle cells, without the same increase in oxygen demand. At the second annual BioPartnering North America conference (BPN-2004) [February 2004, Vancouver, Canada], Cardiome Pharma stated that it was seeking a commercialisation partner to market and distribute oxipurinol in the US for the treatment of allopurinol-intolerant hyperuricaemia. [Drugs R D. 2004;5(3):171-5.] Source: NCBI PubMed, PMID:15139781

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component

Oxipurinol/Creatinine

Property

SRto

Time

Pt

System

Urine

Scale

Qn

Method

Additional Names

Long Common Name

Oxipurinol/Creatinine [Molar ratio] in Urine

Short Name

Oxipurinol/Creat Ur-sRto

Display Name

Oxipurinol/Creatinine (U) [Molar ratio]

Consumer Name Alpha Get Info

Oxipurinol/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.48

Last Updated

Version 2.54

Order vs. Observation

Both

Member of these Panels

Language Variants Get Info

Related Names

• Allopurinol metabolite
• alloxanthine
• Chemistry
• CR
• Crea
• Creat
• Oxyprim
• oxypurinol
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Scrto
• Substance concentration ratio
• Substance ratio
• UA
• UCr
• UR
• Urn

Example Units

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CodeSystem lookup

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