Version 2.77

Term Description

Detects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 18 and 45 in cervical specimens from women with positive HPV assay results. E6/E7 oncogenes must be expressed for malignant transformation. For women 21-years and older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results, and HPV positive assay results, this assay can be used to assess the presence or absence of high-risk HPV genotypes 18, and/or 45. For women 30-years and older, the HPV 18, and/or 45 genotype assay can be used to test samples from women with HPV assay positive results, along with cervical cytology results. This assay has not been evaluated for HPV vaccinated patients or in cases of suspected abuse. It does not differentiate HPV 18 and HPV 45. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay which uses target capture, target amplification by transcription-mediated amplification and detection of the amplification products by hybridization protection. To report results for HPV 16 see Human papilloma virus 16 E6+E7 mRNA [Presence] in Cervix by Probe and signal amplification method [LOINC: 82456-5].
Source: Regenstrief LOINC

Part Description

LP185927-3   Human papilloma virus 18+45 E6+E7 mRNA
HPV type 16 and 18 are the most common carcinogenic HPV types. HPV type 16 is detected in about 50% of invasive cervical cancers worldwide and is associated with a higher risk of a severe cervical intraepithelial neoplasia (CIN 3). HPV type 16 is one of the greatest risks for HPV persistence along with increasing age, smoking, immunosuppression, inflammation, hormones, and genetic factors. HPV type 18 is detected in 10% to 20% of invasive cervical cancers and more commonly found in adenocarcinomas compared to squamous-cell cervical carcinomas. PMID: 19061814 Source: Regenstrief LOINC, PMID: 19061814

Fully-Specified Name

Component
Human papilloma virus 18+45 E6+E7 mRNA
Property
PrThr
Time
Pt
System
Cvx
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
HPV18+45 E6+E7 mRNA Cvx Ql NAA+probe
Display Name
HPV 18+45 E6+E7 mRNA NAA+probe Ql (Cvx)
Consumer Name Alpha Get Info
HPV 18+45 E6+E7 MRNA, Cervix

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016. Changed the method from 'Probe.amp.sig' to 'Probe.amp.tar' to correctly reflex the HPA procedure.
Order vs. Observation
Both
Common Test Rank Get Info
3814

Member of these Panels

LOINC Long Common Name
90766-7 HEDIS 2019 Value Sets
94137-7 HEDIS 2020 Value Sets
96068-2 HEDIS MY 2020 Value Sets
82457-3 Human papilloma virus 16 and 18+45 E6+E7 mRNA panel - Cervix by NAA with probe detection

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Papilomavirus humano 18+45 E6+E7 ARNm:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Virus del papiloma humano 18 + 45 ARNm de E6 + E7:Presencia o umbral:Punto temporal:Cuello uterino:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Papillomavirus humain 18+45 ARNm E6+E7:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Papilloma virus umano 18+45 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar
Synonyms: Cervice uterina Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Humaan papilloma virus 18+45 E6+E7 mRNA:aanwezigheid:moment:cervix:ordinaal:probe-detectie
Synonyms: baarmoederhals probe.amp.tar
tr-TR Turkish (Turkey) Human papilloma virüs 18+45 E6+E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf
Synonyms: Mevcut
zh-CN Chinese (China) 人乳头瘤病毒 18+45 E6+E7 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向
Synonyms: HPV 18;HPV 18 型;HPV18;人类乳头瘤病毒 18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV;人乳头瘤病毒(Human papilloma virus,HPV);人类乳头瘤病毒;生殖器疣 人类乳头瘤病毒(HPV) 18+45 E6+E7 mRNA 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 宫颈;生殖道 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针

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