76338-3

Porcine epidemic diarrhea virus RNA [Presence] in Specimen by NAA with probe detection

Active

Term Description

This virus only affects pigs. Testing can be performed on either biological or environmental samples including oral fluid, feces, dirt and others.

Part Description

LP182479-8 Porcine epidemic diarrhea virus
Porcine Epidemic Diarrhea Virus (PEDv) is a large-enveloped RNA virus, which is a member of the genus Alphacoronavirus within the Coronaviridae family. The complete PEDv genome consists of 5 gene segments: open reading frame 1 (ORF1), spike (S), envelope (E), membrane (M), and nucleocapsid (N). It is encapsulated by a single N protein. The S protein contributes to the stimulation of neutralizing antibodies in the infected host. Its association to adapted growth in vitro and attenuation in vivo lends itself to use for genetic comparison among PEDV isolates and effective vaccines. The M protein is required for assembly and can also induce the production of virus-neutralizing antibodies. The E protein contributes to coronavirus budding. The N protein has functions associated with viral replication and pathogenesis.
PEDv causes viral enteritis, which leads to the destruction of villus enterocytes in pigs of all ages. It is spread by the ingestion of feces from infected pigs, resulting in vomiting, watery diarrhea, dehydration, and high mortality, especially in nursery piglets. Disease caused by PEDv is clinically similar to that caused by Transmissible gastroenteritis coronavirus (TGEV) PMID: 26689811
At least two PEDv strains have been identified in the USA: the US PEDv prototype and S INDEL variant. The INDEL variant PEDv strain has insertions and deletions (INDELs) in the spike (S) gene. PMID: 25279722 The INDEL strain is related to milder clinical signs than prototype strains. PMID: 24750580 PMID: 26748596 The genomic differences in the S gene between the US PEDv prototype and INDEL variant may be responsible for the virulence differences. Potential targets when testing for PEDv RNA include the nucleocapsid protein (N) gene and the ~2500 bp fragment of the S-gene. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Porcine epidemic diarrhea virus RNA:PrThr:Pt:XXX:Ord:Probe.amp.tar
Long Common Name: Porcine epidemic diarrhea virus RNA [Presence] in Specimen by NAA with probe detection
Short Name: PEDv RNA Spec Ql NAA+probe
Display Name: Porcine epidemic diarrhea virus RNA NAA+probe Ql (Specimen)
Consumer Name Alpha Get Info: Porcine Epidemic Diarrhea virus, Specimen

Part Model Get Info

Component
Porcine epidemic diarrhea virus RNA
LP182480-6
- Analyte
  Porcine epidemic diarrhea virus RNA
  LP182480-6
  - Component Numerator
    Porcine epidemic diarrhea virus RNA
    LP182480-6
    - Component Numerator Core
      Porcine epidemic diarrhea virus
      LP182479-8
    - Component Numerator Core Suffix
      RNA
      LP32423-3
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
XXX
LP7735-6
- System Core
  XXX
  LP7735-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Probe.amp.tar
LP6464-4

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.52
Last Updated: Version 2.69 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus epidemické prasečí průjmové nemoci (PED) RNA:Přítomnost nebo práh:Časový bod:XXX:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
el-GR	Greek (Greece)	Ιός επιδημικής διάρροιας των χοίρων RNA:PrThr:Pt:XXX:Ord:Ανιχνευτής.ενίσχυση.στόχου Synonyms: MICRO Ord PrThr Pt RNA XXX Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Ιός Ιός επιδημικής διάρροιας των χοίρων Των χοίρων
es-ES	Spanish (Spain)	Virus de la diarrea epidémica porcina RNA:PrThr:Punto temporal:XXX:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	ARN del virus de la diarrea epidémica porcina:Presencia o umbral:Punto temporal:XXX:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
it-IT	Italian (Italy)	Virus della diarrea epidemica suina RNA:PrThr:Pt:XXX:Ord:Sonda.amp.tar Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus PED
nl-NL	Dutch (Netherlands)	'porcine' epizoötisch diarreevirus RNA:aanwezigheid:moment:XXX:ordinaal:probe-detectie Synonyms: epizoötisch diarreevirus van varken porcine probe.amp.tar
pl-PL	Polish (Poland)	Wirus epidemicznej biegunki świń RNA:granica wykrywalności:punkt w czasie:XXX:uporządkowany:sonda.amplifikacja.cel Synonyms: amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy
ru-RU	Russian (Russian Federation)	Свиная эпидемическая диаррея вирус РНК:PrThr:ТчкВрм:XXX:Пор:Проба.усил.миш Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Точка во времени;Момент
tr-TR	Turkish (Turkey)	Porsin epidemik diyare virüsü RNA:MevcEşik:Zmlı:XXX:Srl:Prob.amf.hdf Synonyms: Mevcut
zh-CN	Chinese (China)	猪流行性腹泻病毒 RNA:存在情况或阈值:时间点:XXX:序数型:探针法.基因扩增.靶向 Synonyms: 下痢;泄泻;下利;泻肚不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间核糖核酸;Ribonucleic acid 猪传染性腹泻病毒;PEDv 猪的猪科猪科的经过扩增的脱氧核糖核酸探针

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=76338-3

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.