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Term Description

An interpretation of the acetylcholinesterase (AChE) in amniotic fluid testing result which is used as an aid to diagnose open neural tube defect (NDT) and ventral wall defects. The two most common neural tube defects are spina bifida and anencephaly. When an NTD is suspected based upon maternal serum alpha-fetoprotein (AFP) screening results, or diagnosed via ultrasound, detection of acetylcholinesterase (AChE) in amniotic fluid is a useful diagnostic tool as normal amniotic fluid does not contain AChE, unless from the fetus as a result of an open NTD. The patient's gestational age must be at least 13 weeks (second trimester) for accurate AChE detection. Optimal gestational age is 14 to 18 weeks. If acetylcholinesterase is present genetic consultation and high-resolution ultrasound may be suggested.

Part Descriptions

LP15315-2   Acetylcholinesterase
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7. Source: National Library of Medicine, MeSH 2006

LP15315-2   Acetylcholinesterase
Acetylcholinesterase, an enyzme (EC 3.1.1.7) (AChE) that controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine, is also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase. The ACHE gene is mapped to chromosome 7q22. AChE is found primarily in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses. Two main clinical diagnostic uses are: 1) a second trimester screening test for fetal neural tube defects using amniotic fluid and, 2) in the general population, to detect past exposure to organophosphate insecticides with resultant inhibition of the enzyme using blood. Source: Regenstrief LOINC, Acetylcholinesterase

LOINC Names Get Info

Fully-Specified Name
Acetylcholinesterase:Imp:Pt:Amnio fld:Nar:
Long Common Name
Acetylcholinesterase [Interpretation] in Amniotic fluid Narrative
Short Name
AChE Amn-Imp
Display Name
Acetylcholinesterase Nar (Amn fld) [Interp]
Consumer Name Alpha Get Info
Interpretation of Acetylcholinesterase test result, Amniotic fluid

Part Model Get Info

  • Component
    Acetylcholinesterase
    LP15315-2
    • Analyte
      Acetylcholinesterase
      LP15315-2
      • Component Numerator
        Acetylcholinesterase
        LP15315-2
        • Component Numerator Core
          Acetylcholinesterase
          LP15315-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Amnio fld
    LP7000-5
    • System Core
      Amnio fld
      LP7000-5
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Observation
Common Test Rank Get Info
15145

Member of these Panels

LOINCLong Common Name
76478-7Acetylcholinesterase panel - Amniotic fluid

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Acetylcholinesteráza:Interpretace:Časový bod:Amniová tekutina:Narativní:
el-GRGreek (Greece)Ακετυλοχολινεστεράση:Imp:Pt:Αμνιακό υγρό:Nar:
Synonyms: CHEM Imp Nar Pt Ακετυλοχολινεστεράση Αμνιακό υγρό
es-ESSpanish (Spain)Acetilcolinesterasa:Impresión/interpretación del estudio:Punto temporal:Fluido Ammiótico:Narrativo:
es-MXSpanish (Mexico)Acetilcolinesterasa:Impresión / interpretación del estudio:Punto temporal:Líquido amniótico:Narrativo:
fr-CAFrench (Canada)Acétylcholinestérase:Impression:Temps ponctuel:Liquide amniotique:Narratif:
fr-FRFrench (France)Acétylcholinestérase:Interprétation:Ponctuel:Liquide amniotique:Résultat textuel:
fr-BEFrench (Belgium)Acétylcholinestérase:Impression/interprétation d'étude:Temps ponctuel:Liquide amniotique:Narratif:
it-ITItalian (Italy)Acetilcolinesterasi:Imp:Pt:Liquido amniotico:Nar:
Synonyms: Chimica Impressione/interpretazione di studio Liquido amniotico Punto nel tempo (episodio)
nl-NLDutch (Netherlands)acetylcholinesterase:interpretatie:moment:vruchtwater:tekstueel:
ru-RURussian (Russian Federation)Ацетилхолинэстераза:Впчт:ТчкВрм:Амниотич ждк:Опис:
Synonyms: Амниотическая жидкость Впечатление/интерпретация исследования Описательный Точка во времени;Момент
tr-TRTurkish (Turkey)Asetilkolinesteraz:İzlnm:Zmlı:Amniyon sv:Öykü:
Synonyms: Amniyon mayii
zh-CNChinese (China)乙酰胆碱酯酶:印象:时间点:羊水:叙述型:
Synonyms: AChE;真性胆碱酯酶;真胆碱酯酶;胆碱酯酶 I 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 羊膜水;胎水

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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=76479-5