Version 2.80

Part Descriptions

LP15182-6   Tacrolimus
Tacrolimus (also known as FK-506 or Prograf) is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis. It has strong immunosuppressive properties and is commonly used to prevent allograft rejection in transplant recipients. One of its modes of action is to prevent T-lymphocyte activation. Source: National Library of Medicine, MeSH 2006

LP15182-6   Tacrolimus
Tacrolimus (also called FK-506 or fujimycin, Prograf, Advagraf, or Protopic) is amacrolide lactone, calcineurin inhibitor immunosuppresent used mainly after allogeneic organ transplant to lower the risk of organ rejection. It possesses strong immunosuppressive activity by preventing the activation by of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, TH2-mediated diseases such as Kimura's disease, and the skin condition vitiligo. There are potentially severe side effects from doses that are either too low or too high; inadequate tacrolimus concentrations may result in rejection of the transplanted organ, while high levels may lead to severe adverse effects includin nephrotoxicity, neurotoxicity, gastrointestinal disturbances, diabetogenesis, hypertension and malignant complications. [Wikipedia: Tacrolimus] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Tacrolimus

LP20176-1   trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Trough levels for therapeutic drug monitoring

Fully-Specified Name

Component
Tacrolimus^trough
Property
MCnc
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Long Common Name
Tacrolimus [Mass/volume] in Blood --trough
Short Name
Tacrolimus Trough Bld-mCnc
Display Name
Tacrolimus trough (Bld) [Mass/Vol]
Consumer Name Alpha Get Info
Tacrolimus trough, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
19054

Member of these Groups Get Info

LOINC Group Group Name
LG14573-6 Tacrolimus^trough|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Τακρόλιμους^ελάχιστα επίπεδα:MCnc:Pt:Αίμα:Qn:
Synonyms: MCnc Τακρόλιμους
es-MX Spanish (Mexico) Tacrolimus ^ a través:Concentración de masa:Punto temporal:Sangre:Cuantitativo:
es-ES Spanish (Spain) Tacrolimus^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Takroliimus^baas:MCnc:Pt:B:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA French (Canada) Tacrolimus^Creux:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
fr-FR French (France) Tacrolimus taux résiduel:Masse/Volume:Ponctuel:Sang:Numérique:
fr-BE French (Belgium) Tacrolimus^Creux:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
Synonyms: Minimum, nadir
it-IT Italian (Italy) Tacrolimus^valore minimo:MCnc:Pt:Sangue:Qn:
Synonyms: Concentrazione di Massa FK-506 Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue valore minimo TDM
nl-NL Dutch (Netherlands) tacrolimus^dalspiegel:massa/volume:moment:bloed:kwantitatief:
ru-RU Russian (Russian Federation) Такролимус^остаточная концентрация:МассКонц:ТчкВрм:Кр:Колич:
Synonyms: Количественный Кровь Массовая концентрация минимум концентрации Точка во времени;Момент
tr-TR Turkish (Turkey) Takrolimus^en düşük:KütlKons:Zmlı:Kan:Kant:
zh-CN Chinese (China) 他克莫司^波谷:质量浓度:时间点:全血:定量型:
Synonyms: 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 普乐可复 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血;血液

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77348-1