77348-1

Tacrolimus [Mass/volume] in Blood --trough

Active

Part Descriptions

LP15182-6 Tacrolimus
Tacrolimus (also known as FK-506 or Prograf) is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis. It has strong immunosuppressive properties and is commonly used to prevent allograft rejection in transplant recipients. One of its modes of action is to prevent T-lymphocyte activation. Source: National Library of Medicine, MeSH 2006

LP15182-6 Tacrolimus
Tacrolimus (also called FK-506 or fujimycin, Prograf, Advagraf, or Protopic) is amacrolide lactone, calcineurin inhibitor immunosuppresent used mainly after allogeneic organ transplant to lower the risk of organ rejection. It possesses strong immunosuppressive activity by preventing the activation by of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, TH2-mediated diseases such as Kimura's disease, and the skin condition vitiligo. There are potentially severe side effects from doses that are either too low or too high; inadequate tacrolimus concentrations may result in rejection of the transplanted organ, while high levels may lead to severe adverse effects includin nephrotoxicity, neurotoxicity, gastrointestinal disturbances, diabetogenesis, hypertension and malignant complications. [Wikipedia: Tacrolimus] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tacrolimus

LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Trough levels for therapeutic drug monitoring

LOINC Names Get Info

Fully-Specified Name: Tacrolimus^trough:MCnc:Pt:Bld:Qn:
Long Common Name: Tacrolimus [Mass/volume] in Blood --trough
Short Name: Tacrolimus Trough Bld-mCnc
Display Name: Tacrolimus trough (Bld) [Mass/Vol]
Consumer Name Alpha Get Info: Tacrolimus trough, Blood

Part Model Get Info

Component
Tacrolimus^trough
LP308032-4
- Analyte
  Tacrolimus
  LP15182-6
  - Component Numerator
    Tacrolimus
    LP15182-6
    - Component Numerator Core
      Tacrolimus
      LP15182-6
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  trough
  LP20176-1
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld
LP7057-5
- System Core
  Bld
  LP7057-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.52
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 19054

Member of these Groups Get Info

LOINC Group	Group Name
LG14573-6	Tacrolimus^trough\|MCnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Tacrolimus^Údolní koncentrace:Hmotnostní koncentrace:Časový bod:Krev:Kvantitativní:
el-GR	Greek (Greece)	Τακρόλιμους^ελάχιστα επίπεδα:MCnc:Pt:Αίμα:Qn: Synonyms: DRUG/TOX MCnc Pt Qn Αίμα ελάχιστα επίπεδα Τακρόλιμους
es-MX	Spanish (Mexico)	Tacrolimus ^ a través:Concentración de masa:Punto temporal:Sangre:Cuantitativo:
es-ES	Spanish (Spain)	Tacrolimus^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
et-EE	Estonian (Estonia)	Takroliimus^baas:MCnc:Pt:B:Qn: Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA	French (Canada)	Tacrolimus^Creux:Concentration de masse:Temps ponctuel:Sang:Quantitatif:
fr-FR	French (France)	Tacrolimus^taux résiduel:Masse/Volume:Ponctuel:Sang:Numérique:
fr-BE	French (Belgium)	Tacrolimus^Creux:Concentration de masse:Temps ponctuel:Sang:Quantitatif: Synonyms: Minimum, nadir
it-IT	Italian (Italy)	Tacrolimus^valore minimo:MCnc:Pt:Sangue:Qn: Synonyms: Concentrazione di Massa FK-506 Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue valore minimo TDM
nl-NL	Dutch (Netherlands)	tacrolimus^dalspiegel:massa/volume:moment:bloed:kwantitatief:
ru-RU	Russian (Russian Federation)	Такролимус^остаточная концентрация:МассКонц:ТчкВрм:Кр:Колич: Synonyms: Количественный Кровь Массовая концентрация минимум концентрации Точка во времени;Момент
tr-TR	Turkish (Turkey)	Takrolimus^en düşük:KütlKons:Zmlı:Kan:Kant: Synonyms: çukur düzey
zh-CN	Chinese (China)	他克莫司^波谷:质量浓度:时间点:全血:定量型: Synonyms: 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间普乐可复毒品毒品类水平;浓度;质量浓度(单位体积) 药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血;血液

Example Units

Unit	Source
ng/mL	Example UCUM Units

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