78226-8
MLL gene rearrangements [Interpretation] in Blood or Tissue by FISH Narrative
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Part Descriptions
LP33228-5 MLL gene rearrangements
The MLL gene (lysine (K)-specific methyltransferase 2A) [HGNC Gene ID: 7132] is located on chromosome 11q23. This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] [NCBI Gene ID:4297]
Source: National Center for Biotechnology Information (NCBI) Gene
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
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Source: Wikipedia, FISH
Fully-Specified Name
- Component
- MLL gene rearrangements
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nar
- Method
- FISH
Additional Names
- Short Name
- MLL gene Rear Bld/T FISH-Imp
- Display Name
- MLL gene rearrangements FISH Nar (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- Interpretation of MLL gene rearrangements test result, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.REARRANGE
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.73
- Change Reason
- Changed Order_Obs from 'Observation Only' to 'Both' to fit current order use cases.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 19836
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Reagrupamientos gen MLL: |
| es-MX | Spanish (Mexico) | Reordenamientos del gen MLL: |
| fr-FR | French (France) | MLL gène réarrangements: |
| it-IT | Italian (Italy) | MLL, riarrangiamenti gene: Synonyms: Gene MLL Ibridazione in situ fluorescente (FISH) Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Riarrangiamenti gene MLL Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | MLL genherschikking: Synonyms: MLL gen MLL gentranslocaties |
| tr-TR | Turkish (Turkey) | MLL geni yeniden düzenlemeler: |
| zh-CN | Chinese (China) | MLL 基因重排: Synonyms: ALL1 ALL-1 ALL-1; |
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