Version 2.78

Term Description

HCV Ag assays are used as an aid in the diagnosis of suspected Hepatitis viral (HCV) infection and to monitor the status of infected individuals, i.e., whether the patient's infection has resolved or the patient has become a chronic carrier of the virus. This term was created for, but not limited in use to, the submitter's Architect System, HCV Ag test kit. In the USA the CDC testing algorithm does not include the HCV core antigen.
Source: Regenstrief LOINC

Part Descriptions

LP200104-0   Hepatitis C virus core Ag
Hepatitis C virus (HCV) is a small (50 nm in size), enveloped, single-stranded, positive sense RNA virus in the genus hepacivirus, which is in the Flaviviridae family. More than 170 million people worldwide are affected by hepatitis C, and the majority of patients with acute hepatitis C develop chronic HCV infection, which can result in liver cirrhosis, hepatic failure or hepatocellular carcinoma. The HCV core protein is a highly basic, RNA-binding protein that forms the viral capsid. The E1 and E2 envelope glycoproteins are necessary for viral entry and fusion. Non-structural proteins include NS2, NS3, NS4A and 4B, and NS5A and 5B. The NS2-NS3 complex functions as a protease, and NS3 also has a helicase/NTPase domain. NS4A is a cofactor of NS3 protease activity. NS3-NS4A protease is one target of anti-HCV drugs. NS4B is a membrane anchor for the replication complex, and NS5A plays a role in regulating viral replication. NS5B is an RNA-dependent RNA polymerase. [NCBI Books: NBK1630] Source: Regenstrief LOINC, NCBI Books: NBK1630

LP200105-7   Hepatitis C virus core
Hepatitis C virus (HCV) is a small (50 nm in size), enveloped, single-stranded, positive sense RNA virus in the genus hepacivirus, which is in the Flaviviridae family. More than 170 million people worldwide are affected by hepatitis C, and the majority of patients with acute hepatitis C develop chronic HCV infection, which can result in liver cirrhosis, hepatic failure or hepatocellular carcinoma. The HCV core protein is a highly basic, RNA-binding protein that forms the viral capsid. The E1 and E2 envelope glycoproteins are necessary for viral entry and fusion. Non-structural proteins include NS2, NS3, NS4A and 4B, and NS5A and 5B. The NS2-NS3 complex functions as a protease, and NS3 also has a helicase/NTPase domain. NS4A is a cofactor of NS3 protease activity. NS3-NS4A protease is one target of anti-HCV drugs. NS4B is a membrane anchor for the replication complex, and NS5A plays a role in regulating viral replication. NS5B is an RNA-dependent RNA polymerase. [NCBI Books: NBK1630] Source: Regenstrief LOINC, NCBI Books: NBK1630

Fully-Specified Name

Component
Hepatitis C virus core Ag
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IA

Additional Names

Short Name
HCV core Ag SerPl Ql IA
Display Name
HCV core Ag IA Ql
Consumer Name Alpha Get Info
Hepatitis C virus (HCV) Core antigen, Blood

Example Answer List: LL2017-3

Source: Siemens
Answer Code Score Answer ID
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6
ReactiveCopyright http://snomed.info/sct ID:11214006 Reactive (qualifier value) LA15255-5
NonreactiveCopyright http://snomed.info/sct ID:131194007 Non-reactive (qualifier value) LA15256-3

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG32754-0 Hepatitis C virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Hepatitis-C-Virus Core Ag:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma:Ordinal:Immunoassay
es-ES Spanish (Spain) Core del virus hepatitis C Antígeno:PrThr:Punto temporal:Suero o Plasma:Ord:IA
es-MX Spanish (Mexico) Ag del núcleo del virus de la hepatitis C:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunoensayo
fr-CA French (Canada) Hépatite C virus core, Ag:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:IA
fr-FR French (France) Hépatite C virus core Ag:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunoanalyse
it-IT Italian (Italy) Epatite C virus, core, Ag:PrThr:Pt:Siero/Plasma:Ord:IA
Synonyms: Immunoassay Microbiologia Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Virus dell''epatite C Virus dell''epatite C core
nl-NL Dutch (Netherlands) Hepatitis C-virus core Ag:aanwezigheid:moment:serum of plasma:ordinaal:immunoassay
Synonyms: antigeen IA
pl-PL Polish (Poland) Rdzeń wirusa zapalenia wątroby typu C Ag:granica wykrywalności:punkt w czasie:surowica lub osocze:półilościowy:metoda immunologiczna
Synonyms: Antygen rdzeniowy wirusa zapalenia wątroby typu C
tr-TR Turkish (Turkey) Hepatitis C virüs core Ag:MevcEşik:Zmlı:Ser/Plaz:Srl:İA
Synonyms: Antijen İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) 丙型肝炎病毒核心 抗原:存在情况或阈值:时间点:血清/血浆:序数型:免疫测定法
Synonyms: Ag C 型;丙;丙型 HCV;Hep C;丙型肝炎;丙肝;丙肝病毒;肝炎病毒 C 型 丙型肝炎病毒（C 型肝炎病毒、HCV、Hep C、丙肝病毒、肝炎病毒 C 型）核心 传染性肝炎 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 肝 血清或血浆

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CodeSystem lookup
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