79206-9
inv(2)(p21;p23)(EML4,ALK) fusion transcript [Presence] in Blood or Tissue by FISH
Active
Part Descriptions
LP200476-2 inv(2)(p21;p23)(EML4,ALK)
The inversion on chromosome 2 resulting in the fusion of genes EM4L [HGNC ID: 1316] and ALK [HGNC Gene ID: 427] is a chromosomal abnormality found in various histologic types of non-small-cell lung cancer (NSCLC). The fusion encodes for the EML4-ALK protein, which promotes and maintains cancer cell growth. The detection of EML4-ALK may be useful for predicting the potential response to ALK inhibitors as a therapeutic option for patients with lung cancer. PMID: 19170230
Source: Regenstrief LOINC
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
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Source: Wikipedia, FISH
Fully-Specified Name
- Component
- inv(2)(p21;p23)(EML4,ALK) fusion transcript
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- FISH
Additional Names
- Short Name
- inv(2)(EML4,ALK) Bld/T Ql FISH
- Display Name
- inv(2)(p21;p23)(EML4,ALK) fusion transcript FISH Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- inv(2)(p21;p23)(EML4,ALK) fusion transcript analysis, Blood or tissue specimen
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MOLPATH.INV
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.61
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | inv(2)(p21; |
es-MX | Spanish (Mexico) | transcrito de fusión inv (2) (p21; |
fr-FR | French (France) | inv(2)(p21; |
fr-CA | French (Canada) | inv(2)(p21; |
it-IT | Italian (Italy) | inv(2)(p21; Synonyms: Ibridazione in situ fluorescente (FISH) Inversione genetica Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
nl-NL | Dutch (Netherlands) | inv(2)(p21; |
tr-TR | Turkish (Turkey) | inv(2)(p21; Synonyms: Mevcut |
zh-CN | Chinese (China) | inv(2)(p21; Synonyms: Ⅱ Fluorescent in situ hybridization; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=79206-9
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright