LOINC
Version 2.67

79206-9inv(2)(p21;p23)(EML4,ALK) fusion transcript [Presence] in Blood or Tissue by FISHActive

Part Descriptions

LP200476-2   inv(2)(p21;p23)(EML4,ALK)
The inversion on chromosome 2 resulting in the fusion of genes EM4L [HGNC ID: 1316] and ALK [HGNC Gene ID: 427] is a chromosomal abnormality found in various histologic types of non-small-cell lung cancer (NSCLC). The fusion encodes for the EML4-ALK protein, which promotes and maintains cancer cell growth. The detection of EML4-ALK may be useful for predicting the potential response to ALK inhibitors as a therapeutic option for patients with lung cancer. [PMID: 219170230] Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
inv(2)(p21;p23)(EML4,ALK) fusion transcript
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
FISH

Additional Names

Short Name
inv(2)(EML4,ALK) Bld/T Ql FISH
Display Name
inv(2)(p21;p23)(EML4,ALK) fusion transcript FISH Ql (Bld/Tiss)

Basic Attributes

Class
MOLPATH.INV
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.61
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
inv(2)(p21;p23)(EML4,ALK) 融合转录物:存在情况或阈值:时间点:全血/组织:序数型:FISH
nl-NLDutch (NETHERLANDS)
inv(2)(p21;p23)(EML4,ALK) fusietranscript:aanwezigheid:moment:bloed of weefsel:ordinaal:FISH
fr-FRFrench (FRANCE)
inv(2)(p21;p23)(EML4,ALK) transcrit de fusion:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:FISH
it-ITItalian (ITALY)
inv(2)(p21;p23)(EML4,ALK) , trascritto di fusione:PrThr:Pt:Sangue/Tess:Ord:FISH
es-ESSpanish (SPAIN)
inv(2)(p21;p23)(EML4,ALK) Tránscritos de fusión:PrThr:Punto temporal:Sangre o tejido:Ord:Hibridación in situ fluoresente (FISH)
tr-TRTurkish (TURKEY)
inv(2)(p21;p23)(EML4,ALK) füzyon transkript:MevcEşik:Zmlı:Kan/Dk:Srl:FISH

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79206-9