Version 2.80

Term Description

CSF IgM, IgA, and IgG indexes are indicators of intrathecal immunoglobulin synthesis. The calculations incorporate the CSF-serum albumin quotient, an indicator of blood-brain-barrier (BBB) function, in order to differentiate whether the immunoglobulins found in the CSF were produced intrathecally or leaked across the BBB. These immunoglobulin indexes can be useful in the diagnosis of central nervous system infections, neoplasms and primary neurologic diseases such as multiple sclerosis. They also have the potential to monitor treatment efficacy in conditions such as systemic lupus erythematosus with CNS involvement, in which one study found that all three indexes decreased significantly along with CNS symptoms during successful treatment. The CSF IgM index is calculated as (CSF IgM/serum IgM)/(CSF albumin/serum albumin), which can also be represented as (CSF IgM x serum albumin)/(serum IgM x CSF albumin). PMID: 3899036

Part Description

LP14674-3   IgM
Immunoglobulin M ( IgM) is a glycoprotein that consists of five disulfide-linked structural units (a pentamer) held together by a J chain. On the surface of B lymphocytes, however, IgM is found as a monomer and does not express the J chain. IgM is the first immunoglubulin to be made by a fetus and during an immune response, it is the first immunoglobulin to be detected followed by IgG. IgM is the primary antibody against A and B antigens on red blood cells. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , IgM

Fully-Specified Name

Component
IgM clearance/Albumin clearance
Property
Ratio
Time
Pt
System
Ser+CSF
Scale
Qn
Method

Additional Names

Long Common Name
IgM clearance/Albumin clearance [Ratio] in Serum and CSF
Short Name
IgM/Alb clear Ser+CSF-Rto
Display Name
IgM clearance/Albumin clearance (S+CSF) [Ratio]
Consumer Name Alpha Get Info
IgM Clearance/Albumin Clearance, Serum+Cerebrospinal Fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54 (MIN)
Order vs. Observation
Observation

Formula (Readable)

IgM index = (CSF IgM/serum IgM)/(CSF albumin/serum albumin)

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: IgM-Index /L
el-GR Greek (Greece) Ανοσοσφαιρίνη M Κάθαρση/Αλβουμίνη (Λευκωματίνη) Κάθαρση:Ratio:Pt:Ορός+ΕΝΥ:Qn:
Synonyms: Ratio Αλβουμίνη (Λευκωματίνη) Ανοσοσφαιρίνη M
es-ES Spanish (Spain) IgM Aclaramiento/Albúmina Aclaramiento:Fracción:Punto temporal:Suero y Líquido Cefalorraquideo simultaneamente:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Aclaramiento de IgM / Aclaramiento de albúmina:Proporción:Punto temporal:Suero y LCR:Cuantitativo:
fr-CA French (Canada) IgM, Clairance/Albumine, Clairance:Ratios:Temps ponctuel:Sérum+LCR:Quantitatif:
fr-FR French (France) Immunoglobuline M clairance/albumine clairance:Ratio:Ponctuel:Sérum+Liquide céphalorachidien:Numérique:
it-IT Italian (Italy) IgM, clearance/Albumina, clearance:Rapporto:Pt:Siero+LCS:Qn:
Synonyms: Chimica Liquido cerebrospinale Punto nel tempo (episodio) Siero Siero & LCS
nl-NL Dutch (Netherlands) IgM klaring/albumine klaring:verhouding:moment:serum en liquor cerebrospinalis:kwantitatief:
pl-PL Polish (Poland) IgM klirens/albumina klirens:współczynnik:punkt w czasie:surowica i płyn mózgowo-rdzeniowy:ilościowy:
Synonyms: IgM Klirens IgM Klirens IgM/Klirens albuminy
ru-RU Russian (Russian Federation) IgM Клиренс/Альбумин Клиренс:Отношение:ТчкВрм:Сыв+ЦСЖ:Колич:
Synonyms: Количественный Коэффициент;Соотношение;Пропорция Сыворотка Сыворотка и цереброспинальная жидкость Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) IgM Klirens/Albumin Klirens:Oran:Zmlı:Ser+BOS:Kant:
zh-CN Chinese (China) IgM 清除/白蛋白 清除:比率:时间点:血清+脑脊液:定量型:
Synonyms: Alb;清蛋白;白;白朊;蛋白素;蛋白胚乳;蛋白质.白蛋白;血液制品 - 白蛋白 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 免疫球蛋白 M 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 廓清 廓清;清除率;廓清率 廓清率 时刻;随机;随意;瞬间 来自于不同体系的两个观察指标之比;比;比值 清除率 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清 & 脑脊液;血清 & 脑脊髓液;血清+脑脊髓液;血清与脑脊液;血清与脑脊髓液

Example Units

Unit Source
{ratio} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79406-5