79640-9
Saccharopine/Creatinine [Molar ratio] in Urine
Active
Part Descriptions
LP201690-7 Saccharopine
Saccharopine is an intermediate in the degradation of lysine, formed by condensation of lysine and alpha-ketoglutarate. The saccharopine pathway is the main route for lysine degradation in mammal and its first two reactions are catalyzed by enzymatic activities known as lysine-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH), which reside on a single bifunctional polypeptide (EC EC 1.5.1.8, LOR/SDH). The reactions involved by saccharopine dehydrogenases have a very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH. LOR/SDH has been detected in a number of mammalian tissues, mainly in the liver and kidney, contributing not only to the general nitrogen balance in the organism but also to the controlled conversion of lysine into ketone bodies. A tetrameric form has also been observed in human liver and placenta. LOR activity has also been detected in brain mitochondria during embryonic development, and this opens the question of whether the degradation of lysine has any functional significance during brain development and puts a new focus on the nutritional requirements for lysine in gestation and infancy. Finally, LOR and/or SDH deficiencies seem to be involved in a human autosomic genetic disorder known as familial hyperlysinemia, which is characterized by serious defects in the functioning of the nervous system, and characterized by deficiency in lysine-ketoglutarate reductase, saccharopine dehydrogenase, and saccharopine oxidoreductase activities. Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of saccharopine in the blood) are conditions present in some inherited disorders of lysine degradation. PMID: 463877 PMID: 10567240 PMID: 10772957 PMID: 4809305
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database,
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- Saccharopine/Creatinine
- Property
- SRto
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Short Name
- Saccharopine/Creat Ur-sRto
- Display Name
- Saccharopine/Creatinine (U) [Molar ratio]
- Consumer Name Alpha Get Info
- Saccharopine/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.56
- Change Reason
- Changed Class from CHEM.ESOTERIC to CHEM and added Esoteric tag for more flexibility
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Sacaropina/Creatinina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sacaropina / Creatinina: |
| fr-FR | French (France) | Saccharopine/créatinine: |
| it-IT | Italian (Italy) | Saccaropina/Creatinina: Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza |
| nl-NL | Dutch (Netherlands) | saccharopine/creatinine: Synonyms: kreatinine |
| tr-TR | Turkish (Turkey) | Sakkaropin/Kreatinin: Synonyms: SubsOranı |
| zh-CN | Chinese (China) | 酵母氨酸/肌酐: Synonyms: CR; |
Example Units
| Unit | Source |
|---|---|
| umol/mmol{creat} | Example UCUM Units |
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