80203-3

HIV 1 and 2 Ab [Identifier] in Serum, Plasma or Blood by Rapid immunoassay

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Term Description

This assay detects and differentiates between six distinct HIV antibodies: HIV-1 gp160, gp41, p31, and p24 and HIV-2 gp140 and gp36. It is intended for use as an additional, more specific test to confirm the presence of HIV-1 and HIV-2 antibodies found by screening procedures. It may also be used to confirm the presence of antibodies to HIV-1 and HIV-2 in pediatric subjects (children as young as 2 years of age). Because this assay examines antibodies to 6 distinct proteins, it yields a higher degree of specificity for HIV-1 and -2 compared to other methods (such as Multispot). This term was created for, but not limited in use to, the submitter's Bio-Rad Geenius HIV 1/2 Supplemental test kit.
Source: Regenstrief LOINC

Part Description

LP36650-7 HIV 1 & 2
Human immunodeficiency virus (HIV) is categorized into two types, HIV-1 and HIV-2. Worldwide, most HIV infections are HIV-1, whereas HIV-2 largely has been confined to persons in or from West Africa (1,2). HIV-1 and HIV-2 have the same routes of transmission, and both can cause acquired immunodeficiency syndrome (AIDS) (3); however, HIV-2 infections should be differentiated from HIV-1 infections because they are less likely to cause AIDS and their clinical management differs (4,5). CDC's current surveillance case definition for HIV infection applies to both variants of HIV (6) but lacks criteria for differentiating between HIV-1 and HIV-2.

To enumerate and describe HIV-2 cases reported in the United States, a working case definition was developed. During 1988 through June 2010, a total of 242 HIV-2 cases were reported to CDC. Of these, 166 met the working definition. These HIV-2 cases were concentrated in the Northeast (66%, including 46% in New York City) and occurred primarily among persons born in West Africa (81%). Ninety-seven of the HIV-2 cases also had a positive HIV-1 immunoblot antibody test result (e.g., Western blot). Immunoblot antibody tests currently used to confirm HIV reactive screening tests do not contain reagents specific to HIV-2 and thus are not reliable for identification of HIV-2 infections (7). Additional testing specific to HIV-2 should be considered if HIV-1 test results are atypical or inconsistent with clinical findings, especially for persons from West Africa. If an HIV case is reported to the health department but subsequently identified as HIV-2, health-care providers should update the case report to reflect the correct type. As of June 2012, the Bio-Rad Multispot HIV-1/HIV-2 Rapid Test is FDA approved for distinguishing HIV1 from HIV2. Source: Centers for Disease Control and Prevention, LV Torian, et al. HIV-2 Infection Surveillance -- United States, 1987-2009. Morbidity and Mortality Weekly Report 60(29);985-988. July 29, 2011.

Fully-Specified Name

Component: HIV 1 & 2 Ab
Property: Prid
Time: Pt
System: Ser/Plas/Bld
Scale: Nom
Method: IA.rapid

Additional Names

Long Common Name: HIV 1 and 2 Ab [Identifier] in Serum, Plasma or Blood by Rapid immunoassay
Short Name: HIV 1 & 2 Ab SerPlBld IA.rapid
Display Name: HIV 1 and 2 Ab IA.rapid Nom (S/P/Bld)
Consumer Name Alpha Get Info: HIV 1 and 2 antibody, Blood

Example Answer List: LL3795-3

Source: BIO-RAD

Answer	Code	Score	Answer ID
HIV Negative			LA24959-1
HIV-1 Indeterminate			LA24952-6
HIV-2 Indeterminate			LA24953-4
HIV Indeterminate			LA24954-2
HIV-1 Positive			LA24955-9
HIV-2 Positive			LA24956-7
HIV-2 Positive with HIV-1 cross-reactivity			LA24957-5
HIV Positive untypable (undifferentiated)			LA24958-3

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.54
Last Updated: Version 2.73
Change Reason: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 3526

Member of these Panels

LOINC	Long Common Name
89365-1	HIV 1 and 2 Ab panel - Serum, Plasma or Blood by Rapid immunoassay

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	HIV 1 y 2 Anticuerpos:Presencia o identidad:Punto temporal:Suero, Plasma o Sangre:Nom:IA.rapid
es-MX	Spanish (Mexico)	VIH 1 y 2 Ab:Presencia o identidad:Punto temporal:Suero, plasma o sangre:Nominal:Inmunoensayo rápido
fr-CA	French (Canada)	VIH 1 & 2, Ac:Présence ou identité:Temps ponctuel:Sérum/Plasma/Sang:Nominal:IA.rapide
fr-FR	French (France)	VIH-1 et VIH-2 Ac:Identification:Ponctuel:Sérum/Plasma/Sang:Résultat nominal:Immunoanalyse rapide
fr-BE	French (Belgium)	VIH 1 & 2 Ac:Présence ou identité:Temps ponctuel:Sérum/Plasma/Sang:Nominal:IA.rapid Synonyms: Anticorps HIV HIV 1 HIV 1&2 HIV 1+2
it-IT	Italian (Italy)	HIV 1 & 2 Ab:Prid:Pt:Siero/Plasma/Sangue:Nom:IA.rapido Synonyms: anticorpo Immunoassay Immunoassay rapido Microbiologia Plasma Plasma o Sangue Presenza o Identità Punto nel tempo (episodio) Sangue Siero Siero o Plasma Siero,Plasma o Sangue
nl-NL	Dutch (Netherlands)	HIV 1 & 2 As:identificator:moment:serum of plasma of bloed:nominaal:immunoassay.sneltest Synonyms: antistof; antilichaam IA IA.rapid
pl-PL	Polish (Poland)	HIV 1 i 2 Ab:wykrycie lub identyfikacja:punkt w czasie:surowica, osocze lub krew:cecha:szybka metoda immunologiczna Synonyms: Ludzki wirus niedoboru odporności typu 1 Ludzki wirus niedoboru odporności typu 1 i 2 Ludzki wirus niedoboru odporności typu 1+2 Przeciwciała do HIV 1 i 2 Przeciwciała do HIV 1+2
ru-RU	Russian (Russian Federation)	HIV 1 & 2 Ат:ПрИд:ТчкВрм:Сыв/Плаз/Кр:Ном:IA.rapid Synonyms: Антитело ВИЧ ВИЧ 1 ВИЧ 1 и 2 ВИЧ 1+2 Кровь Номинальный;Именной Плазма Присутствие или Идентификация Сыворотка Сыворотка или Плазма Сыворотка, Плазма или Кровь Точка во времени;Момент
tr-TR	Turkish (Turkey)	HIV 1 ve 2 Ab:MevcKimlik:Zmlı:Ser/Plaz/Kan:Snf:İA.hızlı Synonyms: Ak İmmünölçüm, immünoassay
zh-CN	Chinese (China)	HIV 1 型与 2 型抗体:存在与否或特征标识:时间点:血清/血浆/全血:名义型:免疫测定法.快速 Synonyms: Ⅰ Ⅱ Ab;自身抗体 AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 & 2 Ab HIV 1+2 Ab HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I II 人类免疫缺陷病毒 1 & 2 型 Ab 人类免疫缺陷病毒 1 & 2 型抗体人类免疫缺陷病毒 1 与 2 型 Ab 人类免疫缺陷病毒 1 与 2 型;HIV（人类免疫缺陷病毒、人免疫缺陷病毒、艾滋病病毒） 1 型（I 型）与 2 型（II 型）人类免疫缺陷病毒 1 与 2 型抗体人类免疫缺陷病毒 1+2 型 Ab 人类免疫缺陷病毒 1+2 型;HIV 1+2 型（人类免疫缺陷病毒 1+2 型、人类免疫缺陷病毒 I+II 型、人免疫缺陷病毒 1+2 型、人免疫缺陷病毒 I+II 型、HIV I+II、HIV I+II 型、艾滋病病毒 I+II 型）人类免疫缺陷病毒 1+2 型抗体免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答存在;存在与否;特征标识;身份;身份标识微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）快速免疫测定;快速免疫测定法;快速免疫分析法;快速免疫检定法;快速免疫检定;快速免疫试验;酶免疫测定法.快速;快速酶免疫测定法;快速酶免疫测定;快速酶免疫分析法;快速酶免疫检定法;快速酶免疫检定;快速酶免疫试验时刻;随机;随意;瞬间血;血液血浆或全血;血浆/血液;血浆或血液血清、血浆或全血;血清、血浆或血液;血清/血浆/血液血清或血浆

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