Version 2.78

Part Description

LP207651-3   HIV 1 proviral DNA tropism
HIV enters cells by attaching first to the CD4 receptor and then to either the CCR5 or CXCR4 molecules, followed by fusion of the viral and cellular membranes. CCR5 coreceptor antagonists prevent HIV entry into target cells by binding to the CCR5 receptors. HIV tropism assays determine whether the HIV binds to CCR5, CXCR4 or both. An HIV tropism assay should be performed whenever the use of a CCR5 antagonist is being considered or a patient has virologic failure on a CCR5 antagonist.
During acute or recent infection, the vast majority of patients harbor a CCR5-binding virus (called R5 tropism), which suggests that the R5 variant is preferentially transmitted. Viruses in many untreated patients exhibit a shift in co-receptor tropism from CCR5 usage to either CXCR4 (X4 tropism) or both (D/M-tropic, which stands for dual or mixed), which is associated with a more rapid decline in CD4 T-cell counts. Patients who have been treated with anti-retroviral drugs and who have extensive drug resistance are more likely to harbor X4- or D/M-tropic variants than untreated patients with comparable CD4 counts. The prevalence of X4- or D/M-tropic variants increases to more than 50% in treated patients who have CD4 counts <100 cells/mm3. [https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf] Source: Regenstrief LOINC, NIH adult and adolescent HIV guidelines

Fully-Specified Name

Component
HIV 1 proviral DNA tropism
Property
Prid
Time
Pt
System
Bld MC
Scale
Nom
Method

Additional Names

Short Name
HIV1 proviral DNA tropism Bld MC
Display Name
HIV 1 proviral DNA tropism Nom (Bld MC)
Consumer Name Alpha Get Info
HIV 1 Proviral DNA Tropism, Blood

Example Answer List: LL2265-8

Source: Regenstrief LOINC
Answer Code Score Answer ID
R5

Viruses or virus populations that use only the CCR5 chemokine co-receptor to infect CD4+ cells.

 LA19204-9
X4

Viruses or virus populations that use only the CXCR4 chemokine co-receptor to infect CD4+ cells.

 LA19205-6
D/M

Dual (D)-tropic: Viruses or virus populations that can use either the CCR5 or CXCR4 co-receptors to infect CD4+ cells. Mixed (M)-tropic: Virus populations that may contain various combinations of R5 virus, X4 virus, and/or dual-tropic viruses

 LA19206-4

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
18174

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Tropismo de VIH 1 en ADN proviral:Presencia o identidad:Punto temporal:Celulas Mononucleares sanguíneas:Nom:
es-MX Spanish (Mexico) Tropismo del ADN proviral del VIH 1:Presencia o identidad:Punto temporal:Células mononucleares de sangre:Nominal:
fr-FR French (France) VIH-1 ADN proviral tropisme:Identification:Ponctuel:Cellules mononucléées de sang périphérique:Résultat nominal:
it-IT Italian (Italy) HIV 1 proviral DNA tropismo:Prid:Pt:Cellule mononucleate da sangue intero:Nom:
Synonyms: Presenza o Identità Punto nel tempo (episodio) Sangue Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) HIV 1 proviraal DNA tropisme:identificator:moment:mononucleaire cellen in bloed:nominaal:
uk-UA Ukrainian (Ukraine) ВІЛ 1 провірусна ДНК тропізм:Наявність або Ідентифікація:МоментЧасу:Кров мононуклеарні клітини:Категорійно:
Synonyms: AIDS; ANTIBIOTIC SUSCEPTIBILITIES; Blood; Deoxyribonucleic acid; HIV type 1; HIV type I; HIV1; HIV1 proviral DNA; HIV1 proviral DNA tropism; Human immunodeficiency virus; i; ID; Identity or presence; Infectious Disease; InfectiousDisease; Nominal; PBMC; Peripheral blood mononuclear cells; Point in time; Random; WB; Whole blood
zh-CN Chinese (China) HIV 1 型前病毒 DNA 嗜性:存在与否或特征标识:时间点:全血单个核细胞:名义型:
Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） 前病毒;人类免疫缺陷病毒 1 型前病毒;人类免疫缺陷病毒 I 型前病毒 HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒 DNA HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒 DNA 嗜性（向性、趋性、趋向性） HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 全血（血液、血）单个核细胞（单核细胞、MC）;全血标本（样品、样本、试样）单个核细胞 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在;存在与否;特征标识;身份;身份标识 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 血;血液

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