8112-5

CD3-CD16+CD56+ (Natural killer) cells/cells in Blood

Active

Term Description

CD3-CD16+CD56+ are cytotoxic lymphoctyes also known as Natural Killer (NK) cells. NK lymphocytes destroy cells that are infected by viruses, cancer cells, or cells that are subject to rejection after tissue transplantation. CD3-CD16+CD56+ kill their target cells by secreting cytoplasmic proteins known as perforin and granzyme. Perforin perforate the target cell membrane to allow the granzyme to infiltrate the target cell which causes cell destruction by apoptosis or necrosis. The NK lymphocytes require activators and inhibitors to control their cytotoxic activity. Decreased levels of CD3-CD16+CD56+ lymphocytes make patients especially susceptible to the early phases of herpes infection. Information from Wikipedia and www.path.sunysb.edu, accessed 2008 09 05.
Source: Regenstrief Institute

Reference Information

Type	Source	Reference
Mapping Guidance	Regenstrief Help	NK cells - note that CD3- means they do not show CD3 markers. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations

LOINC Names Get Info

Fully-Specified Name: Cells.CD3-CD16+CD56+/Cells:NFr:Pt:Bld:Qn:
Long Common Name: CD3-CD16+CD56+ (Natural killer) cells/cells in Blood
Short Name: CD3-CD16+CD56+ Cells NFr Bld
Display Name: CD3-CD16+CD56+ (Natural killer) cells/Cells (Bld)
Consumer Name Alpha Get Info: CD3-CD16+CD56+ (Natural Killer) Cells/cells, Blood

Part Model Get Info

Component
Cells.CD3-CD16+CD56+/Cells
LP445187-0
- Analyte
  Cells.CD3-CD16+CD56+/Cells
  LP445187-0
  - Component Numerator
    Cells.CD3-CD16+CD56+
    LP17742-5
    - Component Numerator Core
      Cells.CD3-CD16+CD56+
      LP17742-5
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    cells
    LP174115-8
    - Component Denominator Core
      cells
      LP174115-8
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NFr
LP6838-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld
LP7057-5
- System Core
  Bld
  LP7057-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CELLMARK
Type: Laboratory
First Released: Version 1.0h(2)
Last Updated: Version 2.79 (NAM)
Change Reason: Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation: Observation
Common Test Rank Get Info: 2098

Member of these Panels

LOINC	Long Common Name
80721-4	Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
98073-0	Natural killer and natural killer T cell subsets panel - Blood
53759-7	Natural killer cell panel - Blood by Flow cytometry (FC)

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Buňky.CD3-CD16+CD56+/100 buněk:Početní podíl:Časový bod:Krev:Kvantitativní:
de-AT	German (Austria)	Synonyms: NK-Zellen [Lympho]
de-DE	German (Germany)	Zellen.CD3-CD16+CD56+/Zellen:Numerische Fraktion:Zeitpunkt:Blut:Quantitativ: Synonyms: NK-Zellen
el-GR	Greek (Greece)	Κύτταρα.CD3-CD16+CD56+/κύτταρα:NFr:Pt:Αίμα:Qn: Synonyms: CD16 CD3 CD56 CELLMARK NFr Pt Qn Αίμα Κύτταρα Κύτταρα.CD3 Κύτταρα.CD3+CD16+ Κύτταρα.CD3+CD16+CD56+ Κύτταρα.CD3-CD16+ Κύτταρα.CD3-CD16+CD56+
es-AR	Spanish (Argentina)	células.células CD3-CD16+CD56+/100 células:fracción de un número:punto en el tiempo:sangre:cuantitativo:
es-ES	Spanish (Spain)	Células CD3-CD16+CD56+/células:Fracción numérica:Punto temporal:Sangre:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Células CD3-CD16 + CD56 + / 100 células:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR	French (France)	CD3-CD16+CD56+/cellules:Fraction de nombres:Ponctuel:Sang:Numérique:
fr-CA	French (Canada)	Cellules.CD3-CD16+CD56+/Cellules:Fraction numérique:Temps ponctuel:Sang:Quantitatif:
it-IT	Italian (Italy)	Cellule.CD3-CD16+CD56+/cellule:NFr:Pt:Sangue:Qn: Synonyms: Cellule CD3 Cellule CD3+CD16+ Cellule CD3+CD16+CD56+ Cellule CD3-CD16+ Cellule CD3-CD16+CD56+ Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
ko-KR	Korean (Korea, Republic Of)	세포.CD3-CD16+CD56+/100 세포:숫자분획:검사시점:전혈:정량:
nl-NL	Dutch (Netherlands)	cellen.CD3-CD16+CD56+/cellen:getalsfractie:moment:bloed:kwantitatief:
pl-PL	Polish (Poland)	Komórki.CD3-CD16-CD56+/komórki:frakcja liczbowa:punkt w czasie:krew:ilościowy: Synonyms: CD16 Komórki CD3+CD16+ Komórki CD3+CD16+CD56+ Komórki CD3-CD16+CD56+
pt-BR	Portuguese (Brazil)	Células.CD3-CD16+CD56+/100 células:NFr:Pt:SgTotal:Qn: Synonyms: ; CD3-CD16+CD56+ Cells; CD3-CD16+CD56+ Cells; CD3+CD16+CD56+ Cells; CD3-CD16+ Cells; CD3+CD16+ Cells; CD3 Cells; Cell; Cellularity; Leu19; Leu-19; NKH1; Neural cell adhesion molecule; NCAM; Leu-4; Leu4; T3; Leu-11; Leu11; Leu11b; Leu-11B; Gated cells; Fr; Number fraction; Percent; Point in time; Random; Blood; WB; Whole blood; Quantitative; QNT; Quant; Quan; CELL MARKERS
ru-RU	Russian (Russian Federation)	Клетки.CD3-CD16+CD56+/клетки:КолДоля:ТчкВрм:Кр:Колич: Synonyms: CD3-CD16+CD56+ (естественные киллеры) клетки;NK Количественный Количество отношение Кровь Точка во времени;Момент
tr-TR	Turkish (Turkey)	Hücreler.CD3-CD16+CD56+/Hücreler:SayFr:Zmlı:Kan:Kant:
uk-UA	Ukrainian (Ukraine)	Клітини.CD3-CD16+CD56+/100 клітин:Чисельна Фракція:МоментЧасу:Кров:Кількісно: Synonyms: Blood; CD3 Cells; CD3+CD16+ Cells; CD3+CD16+CD56+ Cells; CD3-CD16+ Cells; CD3-CD16+CD56+ Cells; Cell; CELL MARKERS; Cellularity; FCGR3A; Gated cells; Leu11; Leu-11; Leu11b; Leu-11B; Leu19; Leu-19; Leu4; Leu-4; Natural killer cells; NCAM; Neural cell adhesion molecule; NKH1; Number fraction; Percent; Point in time; QNT; Quan; Quant; Quantitative; Random; T3; WB; Whole blood
zh-CN	Chinese (China)	细胞.CD3-CD16+CD56+/细胞:计数型分数:时间点:全血:定量型: Synonyms: CD3+CD16+CD56+细胞 CD3+CD16+细胞 CD3-CD16+CD56+细胞 CD3-CD16+细胞 CD3细胞 Leu11;Leu-11;Leu11b;Leu-11B Leu19;Leu-19;NCAM;NKH1;神经细胞粘附分子;神经细胞粘附分子（Neural cell adhesion molecule，NCAM）;神经细胞黏附分子 Leu4;Leu-4;T3 可用数量表示的;定量性;数值型;数量型;连续数值型标尺数量型分数;数量或计数型分数;数量型分数或计数型分数时刻;随机;随意;瞬间细胞含量;细胞性;细胞性质;细胞构成;细胞类细胞标志物血;血液

Example Units

Unit	Source
%	Example UCUM Units
%	REGENSTRIEF
%	eCHN

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=8112-5

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.