Version 2.78

Part Description

LP207955-8   CYP3A4 gene product metabolic activity interpretation
Cytochrome P450 3A4 (abbreviated CYP3A4) is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Over 30 single nucleotide polymorphisms (SNPs) have been identified in this gene, most of which are not clinically significant. Few have been found to decrease catalytic activity with certain ligands, including testosterone and nifedipine, in comparison to wild-type metabolism. Examples of these alleles and associated SNPs include CYP3A4*6 (an A17776 insertion), CYP3A4*17 (15615T>C) and CYP3A4*22 (15389C>T). A full list of alleles, nucleotide changes and their described enzymatic activity can be found at http://www.cypalleles.ki.se/cyp3a4.htm. Source: Regenstrief LOINC

Fully-Specified Name

Component
CYP3A4 gene product metabolic activity interpretation
Property
Imp
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
Molgen

Additional Names

Short Name
CYP3A4 gene prod met act Bld/T-Imp
Display Name
CYP3A4 gene product metabolic activity interpretation Molgen Ql (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info
CYP3A4 gene product metabolic activity interpretation, Blood or tissue specimen

Example Answer List: LL3856-3

Source: Clinical Pharmacogenetics Implementation Consortium
Answer Code Score Answer ID
Ultrarapid metabolizer LA10315-2
Rapid metabolizer LA25390-8
Normal metabolizer LA25391-6
Intermediate metabolizer LA10317-8
Poor metabolizer LA9657-3

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Interpretación de la actividad metabólica del producto del gen CYP3A4:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MX Spanish (Mexico) Interpretación de la actividad metabólica del producto del gen CYP3A4:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-FR French (France) CYP3A4 gène activité métabolique interprétation:Interprétation:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) CYP3A4, interpretazione dell'attività metabolica del prodotto del gene:Imp:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Farmacogenomica Gene CYP3A4 Genetica molecolare Impressione/interpretazione di studio Interpretazione dell''attività metabolica del gene Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP3A4-gen product metabole activiteit interpretatie:interpretatie:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: CYP3A4 gen molgen
zh-CN Chinese (China) CYP3A4 基因产物新陈代谢活性解释:印象:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: CYP3A4 基因产物新陈代谢（代谢）活性解释（说明、阐释、诠释、解释说明） 代谢作用;新陈代谢 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 判读;解释说明;说明;释义;阐明 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 基因产物新陈代谢（代谢）活性解释（说明、阐释、诠释、解释说明） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 活动 细胞色素 P450, 家族 3, 亚家族 A, 多肽 4;cytochrome P450, family 3, subfamily A, polypeptide 4;NCBI NM_017460.3;HLP;CP33;CP34;CYP3A;NF-25;CYP3A3;P450C3;P450PCN1;MGC126680;CYP3A4 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81145-5