Version 2.77

Part Description

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. PMID: 20542248 ] PMID: 25812763
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A RNA
Property
ThreshNum
Time
Pt
System
Respiratory System Specimen
Scale
Qn
Method
Probe.amp.tar

Additional Names

Short Name
FLUAV RNA Ct Resp Qn NAA+probe
Display Name
FLUAV RNA NAA+probe (Respiratory system specimen) [ThreshNum]
Consumer Name Alpha Get Info
Influenza A (Flu A), Respiratory system specimen

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.75
Change Reason
Release 2.75: SYSTEM: There are 2 similar system's in LOINC: 1- Respiratory system 2- Respiratory specimen Due to an applied logic, the display in the System axis for 1 is Respiratory (adjective) without specification of sample, specimen, or other specific noun, while 2 is displayed fully as Respiratory specimen. Therefore for now we replaced 1 with Respiratory system specimen, which will affect 83 term. The result is replacing "Respiratory" with "Respiratory system specimen". This is the short approach. The bigger project is to potentially merge data that has either 1 or 2 together. This is a project to pass by the laboratory committee and will involve about 1500 concepts.;
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
81233-9 Influenza virus types A and B and subtypes RNA panel - Respiratory system specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG32757-3 Influenza virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Influenza-Virus A RNA:Ct-Wert:Zeitpunkt:Probenmaterial vom Respirationstrakt:Quantitativ:Zielfragmentamplifikation mit Sondendetektion
es-ES Spanish (Spain) Virus Influenza A RNA:ThreshNnum:Punto temporal:Muestra del sistema respiratorio:Qn:Sonda con amplificación dirigida
Synonyms: Cuantitativo Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
es-MX Spanish (Mexico) ARN del virus de la influenza A:ThreshNum:Punto temporal:Espécimen respiratorio:Cuantitativo:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Influenza virus A ARN:Cycle seuil:Ponctuel:Respiratoire:Numérique:PCR amplification de cible
it-IT Italian (Italy) Influenza A, virus RNA:Thresnum:Pt:Campione da Sistema Respiratorio:Qn:Sonda.amp.tar
Synonyms: Campione da Apparato Respiratorio Limite di soglia Microbiologia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus dell''influenza Virus dell''influenza A
nl-NL Dutch (Netherlands) Influenzavirus A RNA:drempelwaarde nummer:moment:respiratoir monster:kwantitatief:probe-detectie
Synonyms: probe.amp.tar systema respiratorium; ademhalingsstelsel
zh-CN Chinese (China) 流感病毒 A 型 RNA:阈值循环圈数:时间点:呼吸系统标本:定量型:探针法.基因扩增.靶向
Synonyms: A 型 A 型流感;A 型流感病毒;FLUA;FLUAV;家禽鼠疫;流感 A;流感 A 型;流感甲型;流感病毒甲型;甲型流感;甲型流感病毒;瘟疫;禽流感;禽流行性感冒;禽疫;鸡瘟 A 型流感病毒 RNA FLUA RNA FLUAV RNA FLUV;Influ;列性感冒病毒;流行性感冒病毒 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 受检物 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 呼吸道标本（样品、样本）;呼吸系统标本（样品、样本） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 样品 样本 核糖核酸;Ribonucleic acid 流感病毒甲型 RNA 甲型流感病毒 RNA 界值数;界限数;阀值数;临界值数;阈值循环数;阈值数;达到阈值时的循环圈数;荧光信号到达设定阈值时所经历的循环数;Ct 值;Cycle threshold;循环阈值 经过扩增的 脱氧核糖核酸探针 试样

Example Units

Unit Source
{Ct_value} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81308-9