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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Glutamate decarboxylase 65 Ab:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
Glutamate decarboxylase 65 Ab [Presence] in Serum by Line blot
Short Name
GAD65 Ab Ser Ql Line blot
Display Name
Glutamate decarboxylase 65 Ab Line blot Ql (S)
Consumer Name Alpha Get Info
Glutamate decarboxylase 65 antibody, Blood

Part Model Get Info

  • Component
    Glutamate decarboxylase 65 Ab
    LP38251-2
    • Analyte
      Glutamate decarboxylase 65 Ab
      LP38251-2
      • Component Numerator
        Glutamate decarboxylase 65 Ab
        LP38251-2
        • Component Numerator Core
          Glutamate decarboxylase 65
          LP18489-2
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.64 (MAJ)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG27801-6Glutamate decarboxylase 65 Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Glutamátdekarboxyláza 65 Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
el-GRGreek (Greece)Γλουταμινική αποκαρβοξυλάση 65 Αντίσωμα:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt SERO Αντίσωμα Γλουταμινική αποκαρβοξυλάση Γλουταμινική αποκαρβοξυλάση 65 Γλουταμινικό οξύ Γραμμή κηλίδωσης Ορός
es-ESSpanish (Spain)Glutamato decarboxilasa 65 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)Glutamato descarboxilasa 65 Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CAFrench (Canada)Glutamate décarboxylase 65, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)Glutamate décarboxylase 65 Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)Glutammato decarbossilasi 65 Ab:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpo GAD65 Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)glutamaatdecarboxylase 65 As:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Dekarboksylaza glutaminianu 65 Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:line blot
Synonyms: Dekarboksylaza kwasu glutaminowego o masie 65 kDa;GAD 65 kDa Dekarboksylaza kwasu glutaminowego;GAD Przeciwciała do dekarboksylazy glutaminianowej 65
zh-CNChinese (China)谷氨酸脱羧酶-65 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ab;自身抗体 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体 谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81725-4