Version 2.78

Part Description

LP201690-7   Saccharopine
Saccharopine is an intermediate in the degradation of lysine, formed by condensation of lysine and alpha-ketoglutarate. The saccharopine pathway is the main route for lysine degradation in mammal and its first two reactions are catalyzed by enzymatic activities known as lysine-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH), which reside on a single bifunctional polypeptide (EC EC 1.5.1.8, LOR/SDH). The reactions involved by saccharopine dehydrogenases have a very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH. LOR/SDH has been detected in a number of mammalian tissues, mainly in the liver and kidney, contributing not only to the general nitrogen balance in the organism but also to the controlled conversion of lysine into ketone bodies. A tetrameric form has also been observed in human liver and placenta. LOR activity has also been detected in brain mitochondria during embryonic development, and this opens the question of whether the degradation of lysine has any functional significance during brain development and puts a new focus on the nutritional requirements for lysine in gestation and infancy. Finally, LOR and/or SDH deficiencies seem to be involved in a human autosomic genetic disorder known as familial hyperlysinemia, which is characterized by serious defects in the functioning of the nervous system, and characterized by deficiency in lysine-ketoglutarate reductase, saccharopine dehydrogenase, and saccharopine oxidoreductase activities. Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of saccharopine in the blood) are conditions present in some inherited disorders of lysine degradation. PMID: 463877 PMID: 10567240 PMID: 10772957 PMID: 4809305 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database,

Fully-Specified Name

Component
Saccharopine
Property
SCnc
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
Saccharopine CSF-sCnc
Display Name
Saccharopine (CSF) [Moles/Vol]
Consumer Name Alpha Get Info
Saccharopine, Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.56
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
35507-3 Amino acids panel [Moles/volume] - Cerebral spinal fluid

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Saccharopin:Stoffmengenkonzentration:Zeitpunkt:Liquor:Quantitativ:
Synonyms: Zerebrospinalflüssigkeit
es-ES Spanish (Spain) Sacaropina:Concentración de sustancia:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Sacaropina:Concentración de sustancias:Punto temporal:Fluído espinal cerebral:Cuantitativo:
fr-FR French (France) Saccharopine:Moles/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
it-IT Italian (Italy) Saccaropina:SCnc:Pt:LCS:Qn:
Synonyms: Chimica Concentrazione di Sostanza Liquido cerebrospinale Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) saccharopine:mol/volume:moment:liquor cerebrospinalis:kwantitatief:
tr-TR Turkish (Turkey) Sakkaropin:SubKons:Zmlı:BOS:Kant:
zh-CN Chinese (China) 酵母氨酸:物质的量浓度:时间点:脑脊液:定量型:
Synonyms: CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 酵母胺酸

Example Units

Unit Source
umol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81781-7