Version 2.78

Term Description

Detects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 16, 18, and 45 in cervical specimens from women with positive HPV assay results. For women 21-years and older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results, and HPV positive assay results, this assay can be used to assess the presence or absence of high-risk HPV genotypes 16, 18, and/or 45. For women 30-years and older, the HPV 16, 18, and/or 45 genotype assay can be used to test samples from women with HPV assay positive results, along with cervical cytology results. This assay has not been evaluated for HPV vaccinated patients or in cases of suspected abuse. It differentiates HPV 16 from HPV 18 and/or HPV 45, but does not differentiate HPV 18 and HPV 45. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay which uses target capture, target amplification by transcription-mediated amplification and detection of the amplification products by hybridization protection assay (HPA).
Source: Regenstrief LOINC

Part Description

LP184364-0   Human papilloma virus 16 & 18+45 E6+E7 mRNA
A group of about 30 HPVs, typically transmitted through sexual contact. Genital HPV infection is very common, with estimates suggesting that up to 75% of women will become infected with one or more of the sexually transmitted HPV types at some point during adulthood (Baseman and Koutsky, 2005). Some sexually transmitted HPVs, such as types 6 and 11, can cause genital warts. However, most HPV types that infect the genitals tend not to cause noticeable symptoms. Persistent infection with a subset of about a dozen so-called high-risk sexually transmitted HPVs, including types 16,18,31, and 33, can lead to the development of anogenital cancers, including cervical, penile and anal. HPV infection is a necessary factor in the development of nearly all cases of cervical cancer (Walboomers 1999). Cervical Pap smear testing is used to detect HPV-induced cellular abnormalities. This allows targeted surgical removal of pre-cancerous lesions prior to the development of invasive cervical cancer. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Human papilloma virus (Wikipedia)

Fully-Specified Name

Component
Human papilloma virus 16 & 18+45 E6+E7 mRNA
Property
Prid
Time
Pt
System
Cvx
Scale
Nom
Method
Probe.amp.tar

Additional Names

Short Name
HPV16+18+45 E6+E7mRNA Cvx NAA+probe
Display Name
HPV 16 and 18+45 E6+E7 mRNA NAA+probe Nom (Cvx)
Consumer Name Alpha Get Info
HPV 16 and 18+45 E6+E7 MRNA, Cervix

Example Answer List: LL2997-6

Source: Ministry St. Michaels Hospital
Answer Code Score Answer ID
Negative - 16, Negative - 18/45 LA21378-7
Negative - 16, Positive - 16/45 LA21379-5
Positive - 16, Negative - 18/45 LA21380-3
Positive - 16, Positive - 18/45 LA21381-1
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
8979

Member of these Panels

LOINC Long Common Name
90766-7 HEDIS 2019 Value Sets
94137-7 HEDIS 2020 Value Sets
96068-2 HEDIS MY 2020 Value Sets

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Papilomavirus humano 16 y 18+45 E6+E7 ARNm:Presencia o identidad:Punto temporal:Cuello uterino:Nom:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Virus del papiloma humano 16 y 18 + 45 ARNm de E6 + E7:Presencia o identidad:Punto temporal:Cuello uterino:Nominal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Papillomavirus humain 16 et 18+45 E6+E7 ARNm:Identification:Ponctuel:Col de l'utérus:Résultat nominal:PCR amplification de cible
it-IT Italian (Italy) Papilloma virus umano 16 & 18+45 E6+E7 mRNA:Prid:Pt:Cvx:Nom:Sonda.amp.tar
Synonyms: Cervice uterina Microbiologia Papilloma virus umano 16 e 18 Papilloma virus umano 16 e 18+45 E6+E7 mRNA Presenza o Identità Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Humaan papillomavirus 16 & 18+45 E6+E7 mRNA:identificator:moment:cervix:nominaal:probe-detectie
Synonyms: baarmoederhals probe.amp.tar
tr-TR Turkish (Turkey) Human papilloma virüs 16 ve 18+45 E6+E7 mRNA:MevcKimlik:Zmlı:Cvx:Snf:Prob.amf.hdf
zh-CN Chinese (China) 人乳头瘤病毒 16 与 18+45 E6+E7 mRNA:存在与否或特征标识:时间点:子宫颈:名义型:探针法.基因扩增.靶向
Synonyms: HPV 16 & 18;HPV 16 & 18 型;HPV16 & 18;人类乳头瘤病毒 16 & 18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16;HPV 16 型;HPV16;人类乳头瘤病毒 16 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18;HPV 16+18 型;HPV16+18;人类乳头瘤病毒 16+18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV;人乳头瘤病毒（Human papilloma virus，HPV）;人类乳头瘤病毒;生殖器疣 人类乳头瘤病毒（HPV） 16 与 18+45 E6+E7 mRNA 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 宫颈;生殖道 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针

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