82457-3
Human papilloma virus 16 and 18+45 E6+E7 mRNA panel - Cervix by NAA with probe detection
Active
75694-0 Human papilloma virus 18+45 E6+E7 mRNA [Presence] in Cervix by NAA with probe detection
Term Description
Detects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 18 and 45 in cervical specimens from women with positive HPV assay results. E6/E7 oncogenes must be expressed for malignant transformation. For women 21-years and older with atypical squamous cells of undetermined significance (ASC-US) cervical cytology results, and HPV positive assay results, this assay can be used to assess the presence or absence of high-risk HPV genotypes 18, and/or 45. For women 30-years and older, the HPV 18, and/or 45 genotype assay can be used to test samples from women with HPV assay positive results, along with cervical cytology results. This assay has not been evaluated for HPV vaccinated patients or in cases of suspected abuse. It does not differentiate HPV 18 and HPV 45. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay which uses target capture, target amplification by transcription-mediated amplification and detection of the amplification products by hybridization protection. To report results for HPV 16 see Human papilloma virus 16 E6+E7 mRNA [Presence] in Cervix by Probe and signal amplification method [LOINC: 82456-5].
Source: Regenstrief LOINC
Part Descriptions
LP185927-3 Human papilloma virus 18+45 E6+E7 mRNA
HPV type 16 and 18 are the most common carcinogenic HPV types. HPV type 16 is detected in about 50% of invasive cervical cancers worldwide and is associated with a higher risk of a severe cervical intraepithelial neoplasia (CIN 3). HPV type 16 is one of the greatest risks for HPV persistence along with increasing age, smoking, immunosuppression, inflammation, hormones, and genetic factors. HPV type 18 is detected in 10% to 20% of invasive cervical cancers and more commonly found in adenocarcinomas compared to squamous-cell cervical carcinomas. PMID: 19061814
Source: Regenstrief LOINC, PMID: 19061814
Fully-Specified Name
- Component
- Human papilloma virus 18+45 E6+E7 mRNA
- Property
- PrThr
- Time
- Pt
- System
- Cvx
- Scale
- Ord
- Method
- Probe.amp.tar
Additional Names
- Short Name
- HPV18+45 E6+E7 mRNA Cvx Ql NAA+probe
- Display Name
- HPV 18+45 E6+E7 mRNA NAA+probe Ql (Cvx)
- Consumer Name Alpha Get Info
- HPV 18+45 E6+E7 MRNA, Cervix
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.50
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016. Changed the method from 'Probe.amp.sig' to 'Probe.amp.tar' to correctly reflex the HPA procedure.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 3814
Example Answer List LL360-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 90766-7 | HEDIS 2019 Value Sets |
| 94137-7 | HEDIS 2020 Value Sets |
| 96068-2 | HEDIS MY 2020 Value Sets |
| 82457-3 | Human papilloma virus 16 and 18+45 E6+E7 mRNA panel - Cervix by NAA with probe detection |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Papilomavirus humano 18+45 E6+E7 ARNm: |
| es-MX | Spanish (Mexico) | Virus del papiloma humano 18 + 45 ARNm de E6 + E7: |
| fr-FR | French (France) | Papillomavirus humain 18+45 ARNm E6+E7: |
| it-IT | Italian (Italy) | Papilloma virus umano 18+45 E6+E7 mRNA: Synonyms: Cervice uterina Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA |
| nl-NL | Dutch (Netherlands) | Humaan papilloma virus 18+45 E6+E7 mRNA: Synonyms: baarmoederhals probe.amp.tar |
| tr-TR | Turkish (Turkey) | Human papilloma virüs 18+45 E6+E7 mRNA: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 人乳头瘤病毒 18+45 E6+E7 mRNA: Synonyms: HPV 18; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
82456-5 Human papilloma virus 16 E6+E7 mRNA [Presence] in Cervix by NAA with probe detection
Term Description
Detects E6/E7 viral messenger RNA (mRNA) of human papillomavirus (HPV) types 16 in cervical specimens from women with positive HPV screening assay results. This term was created for, but not limited in use to, the Aptima HPV 16 18/45 genotype assay.To report results for HPV 18/45 use Human papilloma virus 18+45 E6+E7 mRNA [Presence] in Cervix by Probe and signal amplification method [LOINC: 75694-0].
Source: Regenstrief LOINC
Part Descriptions
LP221166-4 Human papilloma virus 16 E6+E7 mRNA
Human papilloma virus (HPV) is a double-stranded DNA virus that includes 120 types that infect cutaneous and mucosal epithelial cells. The HPV that infect the cervix are categorized as low or high risk depending upon their carcinogenicity. High risk HPV types can lead to low-grade cervical cell abnormalities, pre-cancerous cellular abnormalities and anogenital cancer. Type 16 is a high risk HPV and is implicated in roughly 50% of cervical cancers around the world. E6/E7 genes in cervical tumors interfere with the control of cell proliferation and cell division and can be used for targeted anti-cancer therapy. PMID: 9448307
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Human papilloma virus 16 E6+E7 mRNA
- Property
- PrThr
- Time
- Pt
- System
- Cvx
- Scale
- Ord
- Method
- Probe.amp.tar
Additional Names
- Short Name
- HPV 16 E6+E7 mRNA Cvx Ql NAA+probe
- Display Name
- HPV 16 E6+E7 mRNA NAA+probe Ql (Cvx)
- Consumer Name Alpha Get Info
- HPV 16 E6+E7 MRNA, Cervix
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 4491
Example Answer List LL360-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 90766-7 | HEDIS 2019 Value Sets |
| 94137-7 | HEDIS 2020 Value Sets |
| 96068-2 | HEDIS MY 2020 Value Sets |
| 82457-3 | Human papilloma virus 16 and 18+45 E6+E7 mRNA panel - Cervix by NAA with probe detection |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | mRNA del virus 16E6+E7 del papiloma humano: |
| es-MX | Spanish (Mexico) | ARNm del virus del papiloma humano 16 E6 + E7: |
| fr-FR | French (France) | Papillomavirus humain 16 ARNm E6+E7: |
| it-IT | Italian (Italy) | Papilloma virus umano 16 E6+E7 mRNA: Synonyms: Cervice uterina Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA |
| nl-NL | Dutch (Netherlands) | Humaan papilloma virus 16 E6+E7 mRNA: Synonyms: baarmoederhals probe.amp.tar |
| zh-CN | Chinese (China) | 人乳头瘤病毒 16 E6+E7 mRNA: Synonyms: HPV 16 E6+E7 mRNA; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.