Version 2.80

Term Description

This assay represents the fraction of T-cell receptor beta chain variable gene segments that are in the TRBV9 gene family out of the total number of TRBV gene segments identified ("diversity ratio"). At the time this term was created, TRBV9 did not contain any subtypes. Because some portion of TRBV gene segments that are counted in the total will not correspond to any of the probes and therefore will not be identified as belonging to a specific TRBV gene family, the total of the diversity ratios reported will not equal 100%.

Part Description

LP220326-5   TRBV9 gene segments
The T-cell receptor (TCR) is a cell-surface receptor that is composed of two polypeptide chains that are linked by a disulfide bond. In peripheral T-cells, approximately 85% of TCR consist of an alpha and beta chain, while the rest have gamma and delta. TCRs have multiple domains including constant (C), variable (V), joining (J) and diversity (D) domains. The TCR beta gene locus (TRB) is located on chromosome 7q34 and includes nearly 70 V genes that are grouped into families ("TRBV families") based upon greater than 75% nucleotide sequence identity. During T-cell development in the thymus, V, D, and J segments undergo somatic rearrangement to form complete V domain exons that are responsible for antigen recognition. The diversity of the T-cell repertoire depends on recombination as well as nucleotide insertion and deletion at junctional sites (V-J, D-J, and V-D). PMID: 12499424 Although nearly 70 TRBV gene segments have been identified, studies have shown that the total number of functional TRBV gene segments expressed by a healthy individual varies from 42 to 47 due to 7 frequently occurring inactivating polymorphisms and a large insertion/deletion-related polymorphism encompassing 2 TRBV gene segments. PMID: 12493004 TRBV repertoire analysis is used to determine the number of gene segments and their relative frequency as expressed by an individual. The total number of gene segments present is identified based on various techniques including fragment length analysis, and specific probes are used to identify a common set of gene segments. From these data, the diversity ratio is calculated as the relative number of gene segments from a particular gene family compared to the total. Because some portion of gene segments that are counted in the total will not correspond to any of the probes and therefore will not be identified as belonging to a specific TRBV gene family, the total of the diversity ratios reported will not equal 100%. Analysis of the TRBV repertoire, including the number of gene families present and their relative proportions can be used to evaluate primary immunodeficiencies, monitor immune reconstitution after hematopoietic steam cell transplantation, and assess temporal repertoire changes in autoimmune diseases and viral infections. Source: Regenstrief LOINC

Fully-Specified Name

Component
TRBV9 gene segments/TRBV gene segments.total
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Long Common Name
TRBV9 gene segments/TRBV gene segments.total in Blood
Short Name
TRBV9 seg/TRBV seg total NFr Bld
Display Name
TRBV9 gene segments/TRBV gene segments.total (Bld)
Consumer Name Alpha Get Info
TRBV9 gene segments/TRBV gene Segments.total, Blood

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58 (ADD)
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Τμήματα γονιδίου TRBV9/Τμήματα γονιδίου TRBV.σύνολο:NFr:Pt:Αίμα:Qn:
Synonyms: NFr Γονίδιο Τμήματα γονιδίου TRBV9
es-ES Spanish (Spain) Segmentos del gen TRBV9/Segmentos del gen TRBV:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Segmentos del gen TRBV9 / segmentos del gen TRBV total:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) TRBV9 gène segments/TRBV gène segments totaux:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) TRBV9, segmenti gene/TRBV, segmenti gene.totale:NFr:Pt:Sangue:Qn:
Synonyms: Frazione numerica Patologia molecolare Punto nel tempo (episodio) Sangue Segmenti gene TRBV9 Totale segmenti gene TRBV
zh-CN Chinese (China) TRBV9 基因片段类/TRBV 基因片段类.总计:计数型分数:时间点:全血:定量型:
Synonyms: TRBV 基因片段类（片段、节段、段）.总计;T 细胞受体 Beta 可变区基因片段;T-细胞受体β可变区基因片段;T Cell Receptor Beta Variable gene segment TRBV9 基因片段类（片段、节段、段）;T 细胞受体 Beta 可变区 9 (基因/假基因) 基因片段;T-细胞受体β可变区 9 (基因/假基因) 基因片段;T Cell Receptor Beta Variable 9 (Gene/Pseudogene) gene segment 全体数量 全部 共计 分子病理学;分子病理学试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总量 总额 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 汇总 血;血液 遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82495-3