82720-4
Natural killer cell cytotoxicity panel - Blood mononuclear cells
Active
88511-1 Natural killer cell cytotoxicity.0.9:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.0.9:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64 (ADD)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 0,9: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 0,9: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 0,9: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células NK. Cociente 0,9: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 0.9/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 0.9: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Cytotoksyczność komórek NK.stosunek komórek efektorowych do docelowych 0,9: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.效应细胞/靶细胞比 0.9: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
88514-5 Natural killer cell cytotoxicity.1.88:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.1.88:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 1,88: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 1,88: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 1,88: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células NK. Cociente 1,88: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. 1.88: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 1.88/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 1.88: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Cytotoksyczność komórek NK.stosunek komórek efektorowych do docelowych 1,88: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.效应细胞/靶细胞比 1.88: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
82724-6 Natural killer cell cytotoxicity.3.13:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.3.13:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.63 (MIN)
- Order vs. Observation
- Observation
Formula (Readable)
Natural killer cytotoxic activity = (Cytotoxic activity at X dilution - spontaneous activity)/Maximum activity
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 3,13: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 3,13: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 3,13: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer. Proporción efector con célula diana 3.13: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. 3.13: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 3.13/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 3.13: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.3.13: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
88515-2 Natural killer cell cytotoxicity.3.75:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.3.75:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 3,75: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 3,75: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 3,75: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células NK. Cociente 3,75: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. 3.75: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 3.75/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 3.75: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Cytotoksyczność komórek NK.stosunek komórek efektorowych do docelowych 3,75: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.效应细胞/靶细胞比 3.75: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
82725-3 Natural killer cell cytotoxicity.6.25:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.6.25:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.63 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 6,25: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 6,25: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 6,25: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer. Proporción efector con célula diana 6.25: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. 6.25: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 6.25/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 6.25: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.6.25: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
88513-7 Natural killer cell cytotoxicity.7.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.7.5:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
| 107613-2 | T-helper 1 and 2 intracellular cytokines Panel - Blood by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 7,5: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 7,5: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 7,5: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células NK. Cociente 7,5: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de las células asesinas naturales. 7,5: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 7.5/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 7.5: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Cytotoksyczność komórek NK.stosunek komórek efektorowych do docelowych 7,5: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.效应细胞/靶细胞比 7.5: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
82726-1 Natural killer cell cytotoxicity.12.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.12.5:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.63 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 12,5: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 12,5: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 12,5: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células asesinas naturales. 12.5: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de las células asesinas naturales. 12.5: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 12.5/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 12.5: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.12.5: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
88512-9 Natural killer cell cytotoxicity.15:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.15:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.70 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 15: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 15: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 15: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células NK. Cociente 15: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de las células asesinas naturales 15: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 15/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 15: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Cytotoksyczność komórek NK.stosunek komórek efektorowych do docelowych 15: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.效应细胞/靶细胞比 15: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
82727-9 Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.25:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.63 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 25: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 25: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 25: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer. Proporción efector con célula diana 25: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de las células asesinas naturales 25: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 25/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 25: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.25: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
88510-3 Natural killer cell cytotoxicity.30:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.30:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64 (ADD)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 30: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 30: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 30: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células NK. Cociente 30: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales Relación de efecto 30: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 30/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 30: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Cytotoksyczność komórek NK.stosunek komórek efektorowych do docelowych 30: Synonyms: Cytotoksyczność komórek NK przy stosunku komórek efektorowych do docelowych 30: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.效应细胞/靶细胞比 30: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
82728-7 Natural killer cell cytotoxicity.50:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.50:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.63 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 50: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 50: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 50: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer. Proporción efector con célula diana 50: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales 50: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 50/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 50: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.50: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
82729-5 Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.63 (MIN)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82720-4 | Natural killer cell cytotoxicity panel - Blood mononuclear cells |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Buňky NK cytotoxicita.poměr efektoru k cílové buňce 100: |
| el-GR | Greek (Greece) | Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 100: Synonyms: HEM/BC Pt Qn RelACnc Αίμα Αίμα Μονοπύρηνα κύτταρα Θετικός μάρτυρας Κυτταροτοξικότητα φυσικών κυττάρων-φονέων.λόγος δραστικών κυττάρων προς κύτταρα-στόχο 100: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer. Proporción efector con célula diana 100: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales: |
| fr-FR | French (France) | Cytotoxicité cellules NK Patient 100/1/contrôle positfif: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità.rapporto 100: Synonyms: Concentrazine Arbitraria Relativa Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.100: Synonyms: Ⅰ I 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |