Version 2.77

Term Description

The quantitative ratios of various steroids in urine are measured to diagnose conditions such as 17-alpha-, 21-, and 11-beta hydroxylase deficiencies, pseudohypoaldosteronismus, 3-beta hydroxysteroid dehydrogenase deficiency, corticosterone methyl oxidase deficiency, 11-beta hydroxysteroid dehydrogenase types 1 and 2 deficiency, and 5-alpha reductase deficiency. The results along with clinical symptoms and past medical history are used for the assessment and treatment of the associated deficiency or condition. Below are examples of various disorders and their associated urinary findings:
1. 17-alpha hydroxylase deficiency: (THA+THB+5aTHB)/(THE+THF+5aTHF) > 10, (THA+THB+5aTHB)/(AN+ET) > 10.
2. 21-hydroxylase deficiency: 17HP/(THE+THF+5aTHF) > 0.25, PT/(THE+THF+5aTHF) > 0.25.
3. 11-beta HSD2 deficiency: (THF+5aTHF)/THE > 3
4. 11-beta HSD1 deficiency: (THF+5aTHF)/THE < 0.1
5. 11-beta hydroxylase deficiency: 100*THS/(THE+THF+5aTHF) > 10, 100*THDOC/(THE+THF+5aTHF) > 10
6. Pseudohypoaldosteronismus: 100*THALDO/(THE+THF+5aTHF) > 5
7. 5-alpha reductase: ET/AN > 5, THF/5aTHF > 10
Where AN = Androsterone, ET= etiocholanolone, 17HP= metabolites of 17-OH-progesterone (pregnandiol, pregnantriol, 17-OH-pregnanolone), THA = tetrahydro compound A, THB = tetrahydrocorticosterone, 5aTHB =5 alpha tetrahydrocorticosterone, THE = tetrahydrocortisone, THF = Tetrahydrocortisone, 5aTHF = 5a-tetrahydrocortisone or Allo-tetrahydrocortisone, THS = tetrahydrodeoxycortisol, THALDO = tetrahydroaldosterone, and THDOC =tetrahydrodeoxycortisone
[NLM Catalog ID: 101631718]
Source: Regenstrief LOINC

Part Description

LP15883-9   Tetrahydrocortisol
Tetrahydrocortisol is the most powerful natural angiostatic steroid. It is involved in C21-Steroid hormone metabolism pathway (KEGG). Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tetrahydrocortisol

Fully-Specified Name

Component
Tetrahydrocortisol/5-alpha tetrahydrocortisol
Property
SRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
THF/5A-THF Ur-sRto
Display Name
Tetrahydrocortisol/5-Alpha tetrahydrocortisol (U) [Molar ratio]
Consumer Name Alpha Get Info
Tetrahydrocortisol/5-Alpha Tetrahydrocortisol, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
73886-4 Steroid fractions panel - Urine

Member of these Groups Get Info

LOINC Group Group Name
LG37538-2 Tetrahydrocortisol/5-alpha tetrahydrocortisol|SRto|Urine

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Tetrahidrocortisol/5-alfa-tetrahidrocortisol:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Tetrahidrocortisol / 5-alfa tetrahidrocortisol:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-FR French (France) Tétrahydrocortisol/5-alpha tétrahydrocortisol:Moles ratio:Ponctuel:Urine:Numérique:
it-IT Italian (Italy) Tetraidrocortisolo/5-Alfa tetraidrocortisolo:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NL Dutch (Netherlands) tetrahydrocortisol/5-alfa-tetrahydrocortisol:molaire verhouding:moment:urine:kwantitatief:
zh-CN Chinese (China) 四氢皮质醇/5-Alpha 四氢皮质醇:物质的量比率:时间点:尿液:定量型:
Synonyms: 5 Alpha-四氢皮质甾醇 5 Alpha-四氢皮醇 5-A 四氢皮质醇;5-α 四氢皮质醇;5-alpha(α、A) 四氢皮质醇(THC、THF、四氢皮质甾醇、四氢皮醇) 5α-四氢皮质甾醇 5α-四氢皮质醇 5α-四氢皮醇 THC;THF;四氢皮质甾醇;四氢皮醇 α 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 阿尔法

Example Units

Unit Source
{ratio} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82909-3