LOINC
Version 2.66

83053-9Cells.programmed cell death ligand 1/100 viable tumor cells in Tissue by Immune stainActive

Component
Cells.programmed cell death ligand 1/100 viable tumor cells
Property
NFr
Time
Pt
System
Tiss
Scale
Qn
Method
Immune stain

Additional Names

Short Name
Cells.PD-L1/100 viab tum NFr Tiss ImStn
Display Name Beta
Cells.programmed cell death ligand 1/100 viable tumor cells Immune stain (Tiss)
Consumer Name Alpha
Cells.programmed Cell Death Ligand 1 Per 100 Viable Tumor Cells, Tissue

Part Description

LP221212-6   Cells.programmed cell death ligand 1
Programmed cell death-ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is the major ligand for the programmed cell death-1 (PD-1) receptor, which is present on the surface of T, B and NK cells and is part of the B7-CD28 superfamily. Binding PD-L1 and PD-L2 to the PD-1 receptor found on T-cells inhibits T cell proliferation and cytokine production. An increase PD-L1 expression occurs in some tumors, which helps protect them against active T-cell immune surveillance by binding to PD-1 and inhibiting the T-cell response. Positive PD-L1 immunohistochemistry in tumor cells may predict tumor response to therapy with immune checkpoint inhibitors, which are a new class of drugs that trigger an immune response against cancer cells by effectively suppressing the tumor’s ability to inhibit the immune response. [PMID: 25682184] Drugs in this class include pembrolizumab and nivolumab, both of which are anti-PD-1 receptor antibodies, and atezolizumab, which is an anti-PD-L1 antibody. PD-L1 may be a prognostic, diagnostic, and therapeutic marker in a variety of neoplasms, including carcinomas of the bladder, lung, and kidney. Source: Regenstrief LOINC

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Observation

Language Variants Get Info

zh-CNChinese (China)
细胞.程序性死亡配体 1/100 个活肿瘤细胞:计数型分数:时间点:组织与涂片:定量型:免疫染色法
nl-NLDutch (Netherlands)
cellen.geprogrammeerde celdood ligand 1/100 levensvatbare tumorcellen:getalsfractie:moment:weefsel en uitstrijkjes:kwantitatief:immunokleuring
it-ITItalian (Italy)
Cellule.ligando 1 di morte cellulare programmata/100 cellule tumorali vitali:NFr:Pt:Tessuto:Qn:Colorazione immunologica
es-ESSpanish (Spain)
Células. Muerte celular programada del ligando 1/100 células tumorales viables:Fracción numérica:Punto temporal:Tejido:Qn:Tinción de inmunohistoquímica

Example Units

Unit Source
% Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83053-9