Version 2.78

Term Description

This term should be used to report the degree of PD-L1 (CD274) protein expression in tumor cells as determined by immune staining with anti-PD-L1 clone SP142. Patients with certain cancers, such as non small cell lung cancer (NSCLC) or urothelial carcinoma, whose tumors are positive for PD-L1 by SP142, may be eligible for anti-programmed death 1 (PD-1) receptor antibody therapy, which effectively prevents the binding of PD-L1 to PD-1. The percentage of viable tumor cells that show partial or complete PD-L1 membrane staining is reported using [LOINC: 83053-9]. If at least 50% of tumor cells or at least 10% of inflammatory cells stain positive with SP142, the tumor is considered to have high PD-L1 expression, and if 1 to 50% of tumor cells and 1 to 10% of inflammatory cells stain positive, the tumor has low expression. If <1% of both tumor and inflammatory cells stain positive, the tumor is considered to have no PD-L1 expression. This term was created for, but is not limited in use to, the Ventana PD-L1 (SP142) assay, which, as of November 2016, is FDA-approved as a companion diagnostic to assess whether patients with certain cancers are eligible for atezolizumab therapy.
Source: Regenstrief LOINC

Fully-Specified Name

Component
Programmed cell death ligand 1 by clone SP142
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
PD-L1 by SP142 Tiss Ql ImStn
Display Name
PD-L1 by clone SP142 Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
PD-L1 by Clone SP142, Tissue

Example Answer List: LL4167-4

Source: Laboratory Corporation of America
Answer Code Score Answer ID
No expression LA26821-1
Low expression LA26820-3
High expression LA26819-5

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
17666

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Ligando 1 de la molécula de muerte programada por el clon SP142 (PD-L1 clon SP142):PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Ligando 1 de muerte celular programada por el clon SP142:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
it-IT Italian (Italy) Morte cellulare programmata ligando 1 tramite clone SP142:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Patologia PD-L1 tramite clone SP142 Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
pl-PL Polish (Poland) Ligand dla receptora programowanej śmierci 1 przez klon SP142:granica wykrywalności:punkt w czasie:tkanka i rozmazy:półilościowy:barwnik immunologiczny
Synonyms: barwnik immunologiczny Ligand dla receptora programowanej śmierci (PD-1) wykryty przez przeciwciało monoklonalne SP142; detekcja PD-L1 przez przeciwciało monoklonalne klon SP142 Ligand receptora programowanej śmierci 1
zh-CN Chinese (China) 采用克隆 SP142 所测定的程序性死亡配体 1:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ⅰ I 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 采用克隆（PD-L1抗体克隆） SP142 所测定的 PD-L1

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83057-0