85360-6

Bordetella pertussis+bronchiseptica+holmesii IS481 DNA [Presence] in Nasopharynx by NAA with non-probe detection

Active

Term Description

This test is primarily for the detection of the IS481 insertional element DNA of the Bordetella pertussis genome in human nasopharyngeal swab samples taken from patients suspected of having respiratory tract infection caused by B. pertussis. The IS481 insertion sequence can also be found in B. holmesii and B. bronchiseptica strains, so respiratory infections with either Bordetella pertussis, B. holmesii or B. bronchiseptica may yield positive test results in this assay, which does not differentiate between these strains. Since B. pertussis and B. holmesii present with similar clinical symptoms, additional testing would need to be performed to differentiate between these strains. This term was created for, but not limited in use to, the illumigene Pertussis DNA Amplification Assay, which uses loop-mediated isothermal DNA amplification (LAMP) technology to detect the IS481 insertional element.

Part Description

LP247783-6 Bordetella pertussis+bronchiseptica+holmesii IS481
A repetitive insertion sequence, IS481, has been found to be present in up to 100 copies within the genome of B. pertussis. In B. holmesii, 8-10 copies of this insertion sequence can be found. PMID: 11326023 On rare occasion, the B. bronchiseptica genome may contain a copy of this sequence. Thus, all these species may test positive in assays targeting the IS481 sequence. Concurrent culturing is used to differentiate species from B. pertussis and confirm the organism, while targeted DNA testing allows preliminary results to be reported the same day that the specimen is received. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:PrThr:Pt:Nph:Ord:Non-probe.amp.tar
Long Common Name: Bordetella pertussis+bronchiseptica+holmesii IS481 DNA [Presence] in Nasopharynx by NAA with non-probe detection
Short Name: B pert+bron+holm IS481 Nph NAA+non-Probe
Display Name: B. pertussis+bronchiseptica+holmesii IS481 DNA NAA+non-probe Ql (Nph)
Consumer Name Alpha Get Info: Bordetella pertussis+bronchiseptica+holmesii IS481, Nasopharynx

Part Model Get Info

Component
Bordetella pertussis+bronchiseptica+holmesii IS481 DNA
LP247781-0
- Analyte
  Bordetella pertussis+bronchiseptica+holmesii IS481 DNA
  LP247781-0
  - Component Numerator
    Bordetella pertussis+bronchiseptica+holmesii IS481 DNA
    LP247781-0
    - Component Numerator Core
      Bordetella pertussis+bronchiseptica+holmesii IS481
      LP247783-6
    - Component Numerator Core Suffix
      DNA
      LP32416-7
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Nph
LP30875-6
- System Core
  Nph
  LP30875-6
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Non-probe.amp.tar
LP208998-7

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.63 (MIN)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
82159-5	Respiratory pathogens DNA and RNA panel - Nasopharynx by NAA with non-probe detection

Member of these Groups Get Info

LOINC Group	Group Name
LG50886-7	Bordetella pertussis+bronchiseptica+holmesii IS481 DNA\|PrThr\|Sys:ANYResp

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Bordetella pertussis+bronchiseptica+holmesii DNA IS481:Přítomnost nebo práh:Časový bod:Nosohltan:Ordinální:Amplifikace nukleových kyselin s detekcí bez sondy
de-DE	German (Germany)	Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:Nachweis oder Schwellenwert:Zeitpunkt:Nasopharynx:Ordinal:Zielfragmentamplifikation mit Detektion ohne Sonde
el-GR	Greek (Greece)	Βακτήριο Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:PrThr:Pt:Nph:Ord:Χωρίς ανιχνευτή.ενίσχυση.στόχου Synonyms: DNA MICRO Nph Ord PrThr Pt Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Βακτήριο Bordetella pertussis Βακτήριο Bordetella pertussis+bronchiseptica+holmesii IS481 Χωρίς ανιχνευτή.ενίσχυση.στόχου
es-ES	Spanish (Spain)	Bordetella pertussis+bronchiseptica+holmesii IS481 ADN:PrThr:Punto temporal:Nasofaringe:Ord:Amplificación del objetivo no basado en sonda
es-MX	Spanish (Mexico)	Bordetella pertussis + bronchiseptica + holmesii IS481 ADN:Presencia o umbral:Punto temporal:Nasofaringe:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-FR	French (France)	Bordetella pertussis+bronchiseptica+holmesii IS481 ADN:Présence/Seuil:Ponctuel:Nasopharynx:Qualitatif:Non-PCR amplification de cible
it-IT	Italian (Italy)	Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:PrThr:Pt:Nph:Ord:Non-sonda.amp.tar Synonyms: Amplificazione target non basata su sonda Microbiologia Presenza o Soglia Punto nel tempo (episodio) Rinofaringe Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
pl-PL	Polish (Poland)	Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:granica wykrywalności:punkt w czasie:nosogardziel:uporządkowany:bez sondy.amplifikacja.cel Synonyms: amplifikacja kwasu nukleinowego z detekcją bez użycia sondy amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy Bordetella pertussis, Bordetella bronchiseptica i Bordetella holmesii sekwencja IS481 Kwas deoksyrybonukleinowy Pałeczka krztuśca
zh-CN	Chinese (China)	百日咳博德特菌+支气管败血性百日咳博德特菌+霍氏博德特菌 IS481 DNA:存在情况或阈值:时间点:鼻咽:序数型:非探针法.基因扩增.靶向 Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向去氧核糖核酸;脱氧核糖核酸去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA）存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间百日咳;百日咳博德特氏菌;胎咳;鸡咳百日咳博德特菌（百日咳博德特氏菌）+支气管败血性百日咳博德特菌（支气管败血性博德特氏菌、支气管败血波氏杆菌、败血波氏杆菌、支气管败血性博德氏杆菌）+霍氏博德特菌（霍氏鲍特菌） IS481 经过扩增的脱氧核糖核酸探针鼻咽标本;鼻咽部;鼻咽部标本

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85360-6

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.