Version 2.78

Term Description

This test is primarily for the detection of the IS481 insertional element DNA of the Bordetella pertussis genome in human nasopharyngeal swab samples taken from patients suspected of having respiratory tract infection caused by B. pertussis. The IS481 insertion sequence can also be found in B. holmesii and B. bronchiseptica strains, so respiratory infections with either Bordetella pertussis, B. holmesii or B. bronchiseptica may yield positive test results in this assay, which does not differentiate between these strains. Since B. pertussis and B. holmesii present with similar clinical symptoms, additional testing would need to be performed to differentiate between these strains. This term was created for, but not limited in use to, the illumigene Pertussis DNA Amplification Assay, which uses loop-mediated isothermal DNA amplification (LAMP) technology to detect the IS481 insertional element.
Source: Regenstrief LOINC

Part Description

LP247783-6   Bordetella pertussis+bronchiseptica+holmesii IS481
A repetitive insertion sequence, IS481, has been found to be present in up to 100 copies within the genome of B. pertussis. In B. holmesii, 8-10 copies of this insertion sequence can be found. PMID: 11326023 On rare occasion, the B. bronchiseptica genome may contain a copy of this sequence. Thus, all these species may test positive in assays targeting the IS481 sequence. Concurrent culturing is used to differentiate species from B. pertussis and confirm the organism, while targeted DNA testing allows preliminary results to be reported the same day that the specimen is received. Source: Regenstrief LOINC

Fully-Specified Name

Component
Bordetella pertussis+bronchiseptica+holmesii IS481 DNA
Property
PrThr
Time
Pt
System
Nph
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Short Name
B pert+bron+holm IS481 Nph NAA+non-Probe
Display Name
B. pertussis+bronchiseptica+holmesii IS481 DNA NAA+non-probe Ql (Nph)
Consumer Name Alpha Get Info
Bordetella pertussis+bronchiseptica+holmesii IS481, Nasopharynx

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82159-5 Respiratory pathogens DNA and RNA panel - Nasopharynx by NAA with non-probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG50886-7 Bordetella pertussis+bronchiseptica+holmesii IS481 DNA|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:Nachweis oder Schwellenwert:Zeitpunkt:Nasopharynx:Ordinal:Zielfragmentamplifikation mit Detektion ohne Sonde
es-ES Spanish (Spain) Bordetella pertussis+bronchiseptica+holmesii IS481 ADN:PrThr:Punto temporal:Nasofaringe:Ord:Amplificación del objetivo no basado en sonda
es-MX Spanish (Mexico) Bordetella pertussis + bronchiseptica + holmesii IS481 ADN:Presencia o umbral:Punto temporal:Nasofaringe:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-FR French (France) Bordetella pertussis+bronchiseptica+holmesii IS481 ADN:Présence/Seuil:Ponctuel:Nasopharynx:Qualitatif:Non-PCR amplification de cible
it-IT Italian (Italy) Bordetella pertussis+bronchiseptica+holmesii IS481 DNA:PrThr:Pt:Nph:Ord:Non-sonda.amp.tar
Synonyms: Amplificazione target non basata su sonda Microbiologia Presenza o Soglia Punto nel tempo (episodio) Rinofaringe Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
zh-CN Chinese (China) 百日咳博德特菌+支气管败血性百日咳博德特菌+霍氏博德特菌 IS481 DNA:存在情况或阈值:时间点:鼻咽:序数型:非探针法.基因扩增.靶向
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 百日咳;百日咳博德特氏菌;胎咳;鸡咳 百日咳博德特菌（百日咳博德特氏菌）+支气管败血性百日咳博德特菌（支气管败血性博德特氏菌、支气管败血波氏杆菌、败血波氏杆菌、支气管败血性博德氏杆菌）+霍氏博德特菌（霍氏鲍特菌） IS481 经过扩增的 脱氧核糖核酸探针 鼻咽标本;鼻咽部;鼻咽部标本

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CodeSystem lookup
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