85365-5

Neutrophil membrane Ab [Presence] in Serum by Immunofluorescence

Active

Term Description

The results of this test are determined by immunofluorescent patterns.

Part Description

LP231983-0 Neutrophil membrane Ab
Antineutrophil membrane antibodies are antibodies that bind to antigens on the surface of neutrophils. Several specific antigens have been identified, but the IgG Fc receptor type 3b is the primary target. It was first recognized that these antibodies were a cause of autoimmune neutropenia (AIN) in 1975. Neutropenia is separated into three categories according to the risk of infection and based on the concentration of circulating neutrophils: mild neutropenia (1000-1500 cells/uL) moderate neutropenia (500-1000 cells/uL) and severe (less than 500 cells/uL). In some AIN the neutrophil numbers are normal but some functions are compromised including their ability to influence adhesion, aggregation, chemotaxis, phagocytosis and metabolic activation. AIN has two subcategories including primary AIN and secondary AIN. In primary AIN there is no association with another pathology. Primary AIN is most common in neonates and results in moderate to severe neutropenia, rarely leads to infection and is self-limiting. Secondary AIN usually occurs following a systemic haematologic disease including infectious diseases, solid or haematological neoplasms, neurological diseases, bone marrow or stem cell transplants, kidney transplants and the use of some drugs. In light of the difficulty in detecting autoimmune antineutrophil antibodies, it is recommended that both immunofluorescent and agglutination tests be performed. PMID: 16207350 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Neutrophil membrane Ab:PrThr:Pt:Ser:Ord:IF
Long Common Name: Neutrophil membrane Ab [Presence] in Serum by Immunofluorescence
Short Name: Neutrophil membrane Ab Ser Ql IF
Display Name: Neutrophil membrane Ab IF Ql (S)
Consumer Name Alpha Get Info: Neutrophil membrane antibody, Blood

Part Model Get Info

Component
Neutrophil membrane Ab
LP231983-0
- Analyte
  Neutrophil membrane Ab
  LP231983-0
  - Component Numerator
    Neutrophil membrane Ab
    LP231983-0
    - Component Numerator Core
      Neutrophil membrane
      LP232480-6
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
IF
LP6323-2

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.61
Last Updated: Version 2.61 (ADD)
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG51665-4	Neutrophil membrane Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Neutrofily membrána Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Imunofluoresecence (IF)
el-GR	Greek (Greece)	Μεμβράνη ουδετερόφιλου Αντίσωμα:PrThr:Pt:Ορός:Ord:Ανοσοφθορισμός Synonyms: Ord PrThr Pt SERO Ανοσοφθορισμός Αντίσωμα Μεμβράνη ουδετερόφιλου Ορός Ουδετερόφιλο
es-ES	Spanish (Spain)	Membrana neutrófila Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunofluorescencia (IF)
es-MX	Spanish (Mexico)	Membrana de neutrófilos Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunofluorescencia (IF)
fr-FR	French (France)	Membrane des polynucléaires neutrophiles Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofluorescence
it-IT	Italian (Italy)	Membrana neutrofili Ab:PrThr:Pt:Siero:Ord:IF Synonyms: anticorpo Immunofluorescenza (IF) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	neutrofiel membraan As:aanwezigheid:moment:serum:ordinaal:immunofluorescentie Synonyms: antistof; antilichaam IF
pl-PL	Polish (Poland)	Neutrofil błona Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:immunofluorescencja Synonyms: Błona neutrofila Neutrofil
zh-CN	Chinese (China)	嗜中性粒细胞膜抗体:存在情况或阈值:时间点:血清:序数型:免疫荧光法 Synonyms: Ab;自身抗体 IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 PMN;中性;中性白细胞;中性粒细胞;嗜中性;嗜中性白细胞;多形核;多形核白细胞;多形核粒细胞;多形核粒细胞（PMN）依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型嗜中性粒细胞（中性、中性粒、中性粒细胞、嗜中性、Neu）膜（细胞膜、胞膜）存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.