85378-8
Erythrocytes.EMA mean fluorescence intensity actual/normal in Blood by Flow cytometry (FC)
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Part Description
LP247810-7 Erythrocytes.EMA mean fluorescence intensity
Eosin-5-maleimide (EMA) is a fluorescent dye used in flow cytometry to screen for hereditary spherocytosis (HS). Patients with HS have red blood cells (RBC) that are overly rigid and misshapen and are removed by the spleen for destruction which leads to anemia, jaundice and splenomegaly. EMA binds covalently to Lys-430 on the first extracellular loop of the Band 3 protein on RBCs. The cytoplasmic portion of Band 3 communicates with ankyrin and protein 4.2 that are crosslinked with the spectrin-based cytoskeleton that acts to stabilize the cell membrane. When band 3 is deficient or abnormal on RBCs fluorescence using EMA may be reduced. The mean fluorescent intensity (MFI) of the patient and control cells is measured and the result is expressed as a ratio of patient MFI to control MFI.[Dacie and Lewis Practical Haematology, 11th edition, Barbara J. Bain, Imelda Bates, Mike A. Laffan, S. Mitchell Lewis, pp250-251]MedlinePlus Condition: hereditary-spherocytosis]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Erythrocytes.EMA mean fluorescence intensity actual/normal
- Property
- RelRto
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- Flow cytometry
Additional Names
- Long Common Name
- Erythrocytes.EMA mean fluorescence intensity actual/normal in Blood by Flow cytometry (FC)
- Short Name
- RBC.EMA MFI Act/Nor Bld FC
- Display Name
- RBC.EMA MFI actual/normal FC (Bld) [Relative ratio]
- Consumer Name Alpha Get Info
- Red Blood Cells EMA Mean Fluorescence Intensity actual/normal, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.61 (ADD)
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Ερυθροκύτταρα.μέση ένταση φθορισμού EMA πραγματικό/φυσιολογικό: Synonyms: RelRto Ερυθροκύτταρα Ερυθροκύτταρα.μέση ένταση φθορισμού EMA |
es-ES | Spanish (Spain) | Eritrocitos. Intensidad media de fluorescencia de EMA actual/normal: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Eritrocitos.EMA intensidad media de fluorescencia real / normal: |
fr-FR | French (France) | Érythrocytes EMA intensité de fluorescence patient/témoin: |
it-IT | Italian (Italy) | Eritrociti.EMA significato dell'intensità della fluorescenza effettivo/normale: Synonyms: Citometria a flusso (FC) Ematologia (coagulazione) conta differenziale Punto nel tempo (episodio) Rapporto Relativo Sangue |
nl-NL | Dutch (Netherlands) | erytrocyten.EMA gemiddelde fluorescentie intensiteit gemeten/normaal: Synonyms: gemeten/normaal |
pl-PL | Polish (Poland) | Erytrocyty, średnia intensywność fluorescencji EMA badane/prawidłowe: Synonyms: Erytrocyty o średniej intensywności fluorescencji EMA, badane Erytrocyty o średniej intensywności fluorescencji EMA, badane/prawidłowe |
zh-CN | Chinese (China) | 红细胞.EMA 平均荧光强度 实际的/正常的: Synonyms: RBC; |
Example Units
Unit | Source |
---|---|
% | Example UCUM Units |
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