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Part Description

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Aquaporin 4 water channel Ab.IgG:Titr:Pt:CSF:SemiQn:Flow cytometry
Long Common Name
Aquaporin 4 water channel IgG Ab [Titer] in Cerebrospinal Fluid by Flow cytometry (FC)
Short Name
AQP4 H2O channel IgG Titr CSF FC
Display Name
Aquaporin 4 water channel IgG FC (CSF) [Titer]
Consumer Name Alpha Get Info
Aquaporin 4 water channel IgG antibody, Spinal fluid

Part Model Get Info

  • Component
    Aquaporin 4 water channel Ab.IgG
    LP39188-5
    • Analyte
      Aquaporin 4 water channel Ab.IgG
      LP39188-5
      • Component Numerator
        Aquaporin 4 water channel Ab.IgG
        LP39188-5
        • Component Numerator Core
          Aquaporin 4 water channel
          LP102619-6
        • Component Numerator Core Suffix
          Ab.IgG
          LP32401-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Titr
    LP6881-9
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    SemiQn
    LP436123-6
  • Method
    Flow cytometry
    LP6274-7

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.83 (MIN)
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG32551-0Aquaporin 4 water channel Ab.IgG|Titr|Pt|CSF

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Akvaporin 4 IgG:Arbitrární koncentrace (titr):Časový bod:Mozkomíšní mok:Semikvantitativní:Průtoková cytometrie
el-GRGreek (Greece)Δίαυλος ύδατος ακουαπορίνης 4 Αντισώματα IgG:Titr:Pt:ΕΝΥ:Ημιποσοτική:Κυτταρομετρία ροής
Synonyms: Pt SERO Titr Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Δίαυλος ύδατος ακουαπορίνης 4 ΕΝΥ Ημιποσοτική Κυτταρομετρία ροής Νερό
es-ESSpanish (Spain)Receptor de Acuaporina 4 IgG:Titulo / Factor de dilución:Punto temporal:Líquido Cefalorraquideo:Semicuantitativo:Citometria de flujo (FC)
Synonyms: Semicuantitativo
es-MXSpanish (Mexico)Acuaporina 4 canal de agua Ab.IgG:Título:Punto temporal:Fluído espinal cerebral:Cuantitativo:Citometría de flujo (FC)
fr-FRFrench (France)Aquaporine 4 récepteur Ac IgG:Titre:Ponctuel:Liquide céphalorachidien:Semi-Quantitatif:Cytométrie de flux
fr-CAFrench (Canada)Canal de l'eau Aquaporin 4, IgG:Titre:Temps ponctuel:LCR:SemiQn:Cytométrie de flux
it-ITItalian (Italy)Acquaporina 4, canale idrico Ab.IgG:Titr:Pt:LCS:SemiQn:Citometria a flusso
Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Citometria a flusso (FC) Liquido cerebrospinale Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NLDutch (Netherlands)aquaporine 4 waterkanaal As.IgG:titer:moment:liquor cerebrospinalis:semikwantitatief:flowcytometrie
Synonyms: antistof; antilichaam
zh-CNChinese (China)水通道蛋白 4 受体 抗体.IgG:滴定度:时间点:脑脊液:半定量型:流式细胞测量术
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O NMO Ab.IgG NMO 抗体.IgG 免疫球蛋白 G 动态 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

Example Units

UnitSource
{titer}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86240-9