Version 2.76

Term Description

This term is created for a test that involves amplification and sequencing of 3 open reading frames of VZV (ORF21, ORF22 and ORF50) to categorize strains into one of the 7 known clades of VZV.
Source: Regenstrief LOINC

Part Description

LP260859-6   Varicella zoster virus clade
Varicella zoster virus (VZV) is a double-stranded alphaherpesvirus that causes seasonal outbreaks of chickenpox and shingles in non-immunized populations. VZV is highly infectious and is transmitted by contact with the ruptured fluid filled blisters and respiratory secretions of infected individuals. Immunity post infection is usually lifelong though the latent virus inhabits the sensory nerve ganglia where it can reactivate causing shingles when immunity declines with aging.[] In the over fifty strains of VZV that have been sequenced it has been found that a single nucleotide polymorphism occurs about every 100 bases. The patterns of polymorphisms in VZV correlate with different geographical regions of infection and is the basis for the classification of viral clades.[] Breuer proposed the nomenclature for the VZV clades as 1-5 with the suspected clades VI and VII to be confirmed later. The geographical regions associated with the seven clades are as follows:
Clades 1 and 3-represent the dominant clades of the circulating VZV in Europe and the Americas
Clades 4 and 5-found in Africa
Clade VI found in France, Italy
Clade VII exclusively isolated in the US
Clade 2-Asia from Korea, Japan, China not found in India, Nepal and Bangladesh where clades 4 and 5 were dominant Source: Regenstrief LOINC

Fully-Specified Name

Varicella zoster virus clade

Additional Names

Short Name
VZV clade Spec
Display Name
VZV clade Molgen Nom (Specimen)
Consumer Name Alpha Get Info
Varicella zoster virus clade, Specimen

Example Answer List: LL4417-3

Source: Regenstrief LOINC
Answer Code Score Answer ID
Varicella-zoster virus clade 1 LA27282-5
Varicella-zoster virus clade 2 LA27283-3
Varicella-zoster virus clade 3 LA27285-8
Varicella-zoster virus clade 4 LA27286-6
Varicella-zoster virus clade 5 LA27287-4
Varicella-zoster virus clade VI LA27288-2
Varicella-zoster virus clade VII LA27289-0
Unable to type LA27090-2
InconclusiveCopyright ID:419984006 Inconclusive (qualifier value) LA9663-1
Test not doneCopyright ID:373121007 Test not done (qualifier value) LA18373-3
Variable LA18409-5

Basic Attributes

First Released
Version 2.61
Last Updated
Version 2.69
Order vs. Observation

Member of these Groups Get Info

LOINC Group Group Name
LG32750-8 Varicella zoster virus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Varicella-Zoster-Virus-Klade:Typ:Zeitpunkt:XXX:Nominal:Molekulargenetisch
es-ES Spanish (Spain) Clados del virus de Varicela Zoster:Tipo:Punto temporal:XXX:Nom:Genética molecular
es-MX Spanish (Mexico) Clado del virus de la varicela zóster:Tipo:Punto temporal:XXX:Nominal:Genética molecular
fr-FR French (France) Varicelle zona virus clade:Type:Ponctuel:Milieux divers:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) Varicella zoster virus clade:Tipo:Pt:XXX:Nom:Molgen
Synonyms: Genetica molecolare Microbiologia Punto nel tempo (episodio) Virus della varicella zoster
nl-NL Dutch (Netherlands) varicella-zostervirus clade:type:moment:XXX:nominaal:moleculair genetisch onderzoek
Synonyms: molgen Varicella zoster virus Varicella zoster virus clade
zh-CN Chinese (China) 水痘带状疱疹病毒进化枝:类型:时间点:XXX:名义型:分子遗传学类实验室方法
Synonyms: HHV-3;VZ;VZV;人类疱疹病毒 3 型;人类疱疹病毒 III 型;带状疱疹;水痘;水痘带状疱疹;水痘病毒;Varicella zoster virus;水痘-带状疱疹病毒 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内,用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 型 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 时刻;随机;随意;瞬间 水痘带状疱疹病毒(HHV-3、VZV、人类疱疹病毒 3 型、疱疹病毒 III 型、带状疱疹病毒、水痘-带状疱疹病毒)进化枝(分支、支、支系、分枝、分化体、种系分枝、演化支)

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