Version 2.80

Term Description

This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Vedolizumab and anti-Vedolizumab test kits.

Part Descriptions

LP250843-2   Vedolizumab
Vedolizumab is a monoclonal antibody used in the treatment of inflammatory bowel disease (IBD) including the subtypes Ulcerative colitis and Crohn's disease. IBD involves inflammation of the intestinal mucosa by leukocytes that cause a disruption in its barrier function. The leukocytes involved are T-cells that express α4β7 integrins which are the target for the drug vedolizumab. Vedolizumab prevents α4β7 integrin from binding with the endothelial surface and T-cells from penetrating the intestinal mucosa. Vedolizumab has proven to be a safe and effective treatment for IBD based in clinical research. Clinical studies have shown that vedolizumab helps achieve corticosteroid-free clinical remission. PMID: 27003961 Source: Regenstrief LOINC

LP250846-5   Vedolizumab Ab
In clinical trials, antibodies to vedolizumab (ATV) were present in about 4% of patients at any given time and were persistent in only 1% or less of patients receiving vedolizumab. [https://www.healthcare.uiowa.edu/path_handbook/handbook/test3424.html] In those patients with anti-vedolizumab antibodies, vedolizumab clearance was increased by about 12%, and for those with persistent antibodies, the trough concentration of vedolizumab was below detectable limits. Anti-drug antibodies can be one cause of treatment failure for vedolizumab as well as other monoclonal antibody therapeutics. PMID: 25996351 Source: Regenstrief LOINC

Fully-Specified Name

Component
Vedolizumab Ab
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Long Common Name
Vedolizumab Ab [Mass/volume] in Serum or Plasma by Immunoassay
Short Name
Vedolizumab Ab SerPl IA-mCnc
Display Name
Vedolizumab Ab IA [Mass/Vol]
Consumer Name Alpha Get Info
Vedolizumab antibody, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
6276

Member of these Panels

LOINC Long Common Name
90794-9 Vedolizumab and Vedolizumab Ab panel [Mass/volume] - Serum or Plasma

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Βεδολιζουμάμπη Αντίσωμα:MCnc:Pt:Ορός/Πλάσμα:Qn:IA
Synonyms: MCnc Βεδολιζουμάμπη
es-ES Spanish (Spain) Vedolizumab Anticuerpos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Vedolizumab Ab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FR French (France) Védolizumab anticorps:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT Italian (Italy) Vedolizumab Ab:MCnc:Pt:Siero/Plasma:Qn:IA
Synonyms: anticorpo Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 维多珠单抗 抗体:质量浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: Ab;自身抗体 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 维多珠;Vedolizumab 单抗;维多株单抗;维多珠单克隆抗体 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86899-2