Version 2.78

Term Description

The patient-specific hemoglobin A1c goal. This goal may be based on population-level or disease-specific guidelines, or may be personalized based on the patient's clinical status.
Source: Regenstrief LOINC

Part Description

LP16413-4   Hemoglobin A1c
Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as "HPLC", "electrophoresis" or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol - no decimals) and NGSP derived units (percentage - one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent - i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.

Studies have demonstrated racial and ethnic differences in the relationship between glucose levels and hemoglobin A1C [22238408], and it has been suggested that some descendants of sub-Saharan Africa may have higher levels of measured hemoglobin A1C compared to glucose levels due to hemoglobin variants PMID: 31675503. Source: Regenstrief Help

Fully-Specified Name

Component
Hemoglobin A1c/Hemoglobin.total goal
Property
MFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
Hgb A1c goal MFr Bld
Consumer Name Alpha Get Info
HbA1c

Basic Attributes

Class
CLIN
Type
Clinical
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
86922-2 Therapeutic goals panel

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Hemoglobina A1C / Hemoglobina objetivo total:Sr.:Punto temporal:Edificio:Cuantitativo:
fr-FR French (France) Hémoglobine A1c/hémoglobine totale cible:Fraction massique:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Emoglobina A1c/Emoglobina.obiettivo totale:MFr:Pt:Sangue:Qn:
Synonyms: Clinico Emoglobina A1c (HgB glicata ) Frazione di massa Obiettivo di emoglobina totale Punto nel tempo (episodio) Sangue
zh-CN Chinese (China) 血红蛋白 A1c/血红蛋白.总计目标:质量分数:时间点:全血:定量型:
Synonyms: GHb;HA1c;HBA1c;Hgb A1c;糖化血红蛋白;糖基化血红蛋白;血红蛋白 A1c （糖化血红蛋白） MFr 全体数量 全部 共计 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总量 总额 时刻;随机;随意;瞬间 氧血红蛋白;血红朊;血红素;血色素 汇总 血;血液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=86910-7