Version 2.77

Part Description

LP262547-5   Clostridium perfringens cpa gene
Clostridium perfringens is a gram positive, anaerobic, rod-shaped bacterium. It is classified into five types designated A through E. Four toxins are produced by C. perfringens that have lethal, necrotic and cytotoxic capabilities. The four toxins are known as alpha-toxin (CPA), beta-toxin (CPB), epsilon-toxin (ETX) and iota-toxin (ITX). PMID: 22069542 When toxins produced by C. perfringens are mixed in different combination, sixteen toxins can be produced. Pathogenesis due to C. perfringens is due almost always to the production of one or more of its toxins. CPA is encoded by the cpa gene that is located on the chromosome and is produced by all strains of C. perfringens. CPA is an enzyme that breaks down phosphatidylcholine and sphingomyelin which damages membrane phospholipids and leads to the lysis of cells. CPA also cause hemolysis, activates the arachidonic cascade and inflammation cascade which induce vasoconstriction. There is no definitive evidence that CPA is involved with enteritis, abomasitis and/or enterotoxemia in cattle, horses, goats, and pigs. In humans, studies support that CPA is the main toxin believed to cause gas gangrene, a disease involving extensive local tissue damage and necrosis that leads to shock and death. Gas gangrene also occurs in domestic animals including sheep, cattle, goats, and horses. PMID: 24511335 Source: Regenstrief LOINC

Fully-Specified Name

Clostridium perfringens cpa gene

Additional Names

Short Name
C perfringens cpa Islt Ql NAA+probe
Display Name
C. perfringens cpa gene NAA+probe Ql (Isol)
Consumer Name Alpha Get Info
Clostridium perfringens cpa gene

Example Answer List: LL4623-6

Answer Code Score Answer ID
PositiveCopyright ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright ID:260385009 Negative (qualifier value) LA6577-6
Suspected LA15291-0
InvalidCopyright ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

First Released
Version 2.63
Last Updated
Version 2.64
Order vs. Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen cpa Clostridium perfringens:PrThr:Punto temporal:Aislado:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Gen cpa de Clostridium perfringens:Presencia o umbral:Punto temporal:Aislado:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Clostridium perfringens cpa gène:Présence/Seuil:Ponctuel:Isolat:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Clostridium perfringens, gene cpa:PrThr:Pt:Isolato:Ord:Sonda.amp.tar
Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Clostridium perfringens cpa-gen:aanwezigheid:moment:isolaat:ordinaal:probe-detectie
Synonyms: probe.amp.tar
zh-CN Chinese (China) 产气荚膜梭菌 cpa 基因:存在情况或阈值:时间点:分离株:序数型:探针法.基因扩增.靶向
Synonyms: 产气荚膜梭状芽胞杆菌;产气荚膜芽孢梭菌 产气荚膜梭菌(产气荚膜梭状芽胞杆菌、产气荚膜芽孢梭菌) cpa 基因 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分离物;分离菌;分离菌株;隔离种群 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 遗传基因;遗传因子;吉恩;生物基因

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