Version 2.77

Term Description

The omega-3 index, defined as eicosapentaenoate (EPA)+ docosahexaenoate (DHA)/Fatty acids.C14-C24, is a clinically useful measurement for evaluating blood levels of EPA and DHA. There are many health benefits from maintaining a good level of omega-3 fatty acids including reduced inflammation, risk of heart disease, cancer, arthritis, and many more. Deficiency in omega-3 fatty acids can result in fatigue, poor memory, dry skin, heart problems, mood swings, and poor circulation.[https://www.umm.edu/health/medical/altmed/supplement/omega3-fatty-acids] There have been a number of clinical trials to determine the effect of omega-3 supplementation based on a 1g/day dose of EPA, which successfully increased the total omega-3 level to >5% for 84% of the study participants. The remaining 16% had levels below 5%, which is the threshold at which significant reduction in sudden coronary death reduction is evident. The variability in the blood levels of omega-3 in patients who received the same supplemental dose of omega-3 has been attributed to genetic differences in fatty acid metabolism, body weight, baseline omega-3 level, age, gender, and physical activity. PMID: 25285179 This test measures the level of omega-3 as a percent of total fatty acids, and the result of that index is associated with a high, moderate, or low risk of cardiovascular disease.
Source: Regenstrief LOINC

Part Descriptions

LP266157-9   Eicosapentaenoate+Docosahexaenoate
Eicosapentaenoate (EPA) is a long chain omega-3 fatty acid that is present throughout the body including in cell membranes. EPA is found in fatty fish including salmon, tuna, mackerel, sardines, shellfish, and herring. EPA can be biosynthesized from alpha-linolenic acid (ALA), but it is much more efficient to increase levels by including EPA-rich sources in one's diet. EPA has anti-inflammatory properties that are vital to fetal development and the process of healthy aging. Its anti-inflammatory effects are due to reduced gene expression of genes involved in inflammatory and atherogenesis-related pathways, thereby lowering the risk of cardiovascular disease. EPA has also been found to increase platelet stability, decrease endothelial activation, and improve vascular permeability. Taking EPA supplements leads to an increased amount of EPA in the plaque of carotid arteries which may decrease inflammation and increase plaque stability. PMID: 22332096 Many other studies have been run that show acorrelation between higher plasma levels of EPA and reduced symptoms of disease, some of which include Alzheimer's disease, depression, rheumatoid arthritis, and Raynaud Syndrome.[ http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000301] Source: Regenstrief LOINC

LP266157-9   Eicosapentaenoate+Docosahexaenoate
Docosahexaenoate (DHA) is one of the essential polyunsaturated omega-3 fatty acids that is primarily obtained by ingesting fatty fish including salmon, mackerel, tuna, herring, and sardines.[https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/] There are many benefits derived from eating healthy levels of DHA including a reduction of chronic inflammation, atherosclerosis, hypertension, arthritis, depression, adult-onset diabetes mellitus, myocardial infarction, thrombosis, and some cancers. DHA is important in brain development of infants and in maintaining normal brain function in adults. Studies have demonstrated that infants who drink DHA-fortified formula have higher visual acuity than infants who drink unfortified formula. Deficiencies of DHA have been associated with fetal alcohol syndrome, attention deficit hyperactivity disorder, cystic fibrosis, phenylketonuria, unipolar depression, aggressive hostility, adrenoleukodystrophy, cognitive decline in aging individuals, and the onset of sporadic Alzheimer's disease. Patients who consume 200 mg/day of DHA have a 50% reduction in the incidence of sudden cardiac arrest. PMID: 10479465 Source: Regenstrief LOINC

Fully-Specified Name

Component
Eicosapentaenoate+docosahexaenoate/Fatty acids.C14-C24 index risk
Property
Imp
Time
Pt
System
Ser/Plas
Scale
Ord
Method

Additional Names

Short Name
Omega-3 index risk SFr SerPl
Display Name
EPA+DHA/Fatty acids.C14-C24 index risk Ql [Interp]
Consumer Name Alpha Get Info
EPA+DHA/Fatty Acids.C14-C24 Index Risk, Blood

Preferred Answer List: LL4892-7

Answer Code Score Answer ID
Index <2.2: High risk of cardiovascular disease LA28572-8
Index 2.2-3.2: Moderate risk of cardiovascular disease LA28573-6
Index >3.2: Low risk of cardiovascular disease LA28574-4

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.64
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
16335

Member of these Panels

LOINC Long Common Name
88884-2 Fatty acid omega-3 and omega-6 panel - Serum or Plasma

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Eicosapentaenoato + Docosahexaenoato/Indice de riesgo acidos grasos C14-C24:Impresión/interpretación del estudio:Punto temporal:Suero o Plasma:Ord:
es-MX Spanish (Mexico) Eicosapentaenoato + docosahexaenoato / Ácidos grasos Índice de riesgo C14-C24:Impresión / interpretación del estudio:Punto temporal:Suero o Plasma:Ordinal:
fr-FR French (France) Eicosapentaénoate+docosahexaénoate/acides gras C14-C24 facteur de risque:Interprétation:Ponctuel:Sérum/Plasma:Qualitatif:
it-IT Italian (Italy) Eicosapentaenoato+Docosaesaenoato/Acidi grassi.C14-C24, fattore di rischio:Imp:Pt:Siero/Plasma:Ord:
Synonyms: Chimica Docosaesaenoato (C22:6w3) Eicosapentaenoato (C20:5w3) Fattore di rischio degli acidi grassi C14-C24 Impressione/interpretazione di studio Plasma Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 二十碳五烯酸+二十二碳六烯酸/脂肪酸类.C14-C24 指数风险:印象:时间点:血清/血浆:序数型:
Synonyms: C20:5w3;EPA;二十碳五烯酸（Eicosapentaenoic acid，EPA）;二十碳五烯酸, C20:5w3;二十碳双烯酸;附子脂酸;附子脂酸, C20:5w3 C22:6w3;DHA;二十二碳六烯酸（Docosahexaenoic acid，DHA）;二十二碳六烯酸, C22:6w3;二十二碳六烯酸 w3 二十碳五烯酸（附子脂酸、EPA、C20:5w3）+二十二碳六烯酸（DHA、C22:6w3、二十二碳六烯酸 w3） 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 时刻;随机;随意;瞬间 类脂化合物;类脂物;脂类;脂肪酸;脂质 脂肪酸.C14-C24 指数风险 血清或血浆

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CodeSystem lookup
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