89358-6
CD27 cells/100 CD19 cells in Blood
Active
Part Descriptions
LP19029-5 Cells.CD27
CD27 and CD45RA are both lymphocyte cell surface markers that can be used to classify T-cells into various subsets. Expression of CD27 is characteristic of naive T-cells and some subsets of memory T-cells, while lack of CD27 is characteristic of effector T-cells. PMID: 19454729. CD45RA is characteristic of resting or naive T-cells. Cells expressing both CD27+CD45RA+ are undifferentiated (naive), CD27+CD45RA- T-cells are at an early stage of differentiation and exhibit characteristics of memory T cells, whereas CD27-CD45RA- T-cells are highly differentiated and have characteristics of both memory and effector T-cells. PMID: 12023349 PMID: 21788446
Source: Regenstrief LOINC
LP266978-8 100 Cells.CD19
The CD19+ B cells are 95 kilo Dalton transmembrane glycoproteins and are comprised of a single transmembrane domain, a cytoplasmic C-terminus, and an extracellular N-terminus. It is a biomarker for normal and neoplastic B cells and for dendritic cells. CD19+ B cells regulate signaling thresholds by modifying B cell receptor dependent and independent signaling, functioning as a dominant piece of a multimolecular complex that resides on the mature B cell surface. The concentration of CD19 on the surface of B cells is tightly controlled throughout the cell's development, making it a very valuable biomarker for B cells. Mature B cells have three times the number of CD19 antigens than immature B cells, and when B cells differentiate into plasma cells, the expression of CD19 is lost. Patients who lack sufficient CD19 antigens have a lower response to transmembrane signals and weak T cell dependent antibody responses. CD19 is highly conserved and expressed in most B cell malignancies including acute lymphocytic leukemia, B cell lymphoma, and B cell leukemia. Efforts are in play to utilize CD19 antibodies for the treatment of lymphoma, leukemia, and autoimmune disorders. PMID: 23210908
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cells.CD27/100 Cells.CD19
- Property
- NFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Additional Names
- Short Name
- CD27 Cells/100 CD19 cells NFr Bld
- Display Name
- CD27 cells/100 CD19 cells (Bld)
- Consumer Name Alpha Get Info
- CD27 cells per 100 CD19 Cells, Blood
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 5305
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 90414-4 | B-cell phenotyping panel - Blood |
| 90416-9 | Lymphocyte subset and B-cell phenotyping panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Células CD27/Porcentaje de células CD19: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Cells.CD27 / 100 Cells.CD19: |
| fr-FR | French (France) | CD27/100 cellules CD19: |
| it-IT | Italian (Italy) | Cellule.CD27/100 Cellule.CD19: Synonyms: 100 cellule CD19 Cellule CD19 Cellule CD27 Cellule CD27- Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue |
| nl-NL | Dutch (Netherlands) | cellen.CD27/100 cellen.CD19: |
| uk-UA | Ukrainian (Ukraine) | Клітини.CD27/100 Клітин.CD19: Synonyms: 100 CD19 cells; |
| zh-CN | Chinese (China) | 细胞.CD27/100 个细胞.CD19: Synonyms: B4; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=89358-6
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright