89368-5
Zika virus non-structural protein 1 IgM panel - Serum or Plasma by Immunoassay
Active
89369-3 Zika virus non-structural protein 1 IgM Ab [Units/volume] in Serum or Plasma by Immunoassay
Part Descriptions
LP221384-3 Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. PMID: 27417494
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. PMID: 27148186
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws.
Source: Regenstrief LOINC
, PMID: 27417494
Fully-Specified Name
- Component
- Zika virus non-structural protein 1 Ab.IgM
- Property
- ACnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.65 (MAJ)
- Change Reason
- Updated the System from Ser to Ser/Plas since this test can be performed on plasma specimens as well.
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 89368-5 | Zika virus non-structural protein 1 IgM panel - Serum or Plasma by Immunoassay |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG32774-8 | Zika virus |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Zika-Virus Nichtstrukturprotein 1 Ak.IgM: |
| el-GR | Greek (Greece) | Μη δομική πρωτεΐνη 1 του ιού Ζίκα Αντισώματα IgM: Synonyms: ACnc Ανοσοσφαιρίνη M Ιός Ιός Ζίκα Μη δομική πρωτεΐνη 1 του ιού Ζίκα Πρωτεΐνη |
| es-MX | Spanish (Mexico) | Proteína 1 Ab.IgM no estructural del virus del Zika: |
| es-ES | Spanish (Spain) | Proteína no estructural del virus del Zica IgM: Synonyms: Cuantitativo |
| fr-FR | French (France) | Zika virus protéine non structurelle 1 Ac IgM: |
| it-IT | Italian (Italy) | Zika virus, proteina non strutturale 1 Ab.IgM: Synonyms: Anticorpi IgM anticorpo Concentrazione Arbitraria Immunoassay Microbiologia Plasma Proteina non strutturale 1 del virus Zika Punto nel tempo (episodio) Siero Siero o Plasma Virus Zika |
| nl-NL | Dutch (Netherlands) | zikavirus niet-structureel proteïne 1 As.IgM: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Wirus Zika białko niestrukturalne 1 Ab.IgM: Synonyms: Białko niestrukturalne 1 wirusa Zika IgM Przeciwciała do białka niestrukturalnego 1 wirusa Zika Przeciwciała IgM do białka niestrukturalnego 1 wirusa Zika |
| zh-CN | Chinese (China) | 寨卡病毒非结构蛋白 1 抗体.IgM: Synonyms: Ⅰ Ab.IgM; |
Example Units
| Unit | Source |
|---|---|
| {EIA_index} | Example UCUM Units |
89370-1 Zika virus non-structural protein 1 IgM Ab [Interpretation] in Serum by Immunoassay
Term Description
Overall interpretation for Zika virus IgM antibody testing based on an algorithm that considers individual quantitative results for IgG and IgM antibodies to Zika virus antigens. This term was created for, but not limited in use to, the submitter's test kit, Diasorin LIAISON(R) XL Zika Capture IgM. In this assay, the result of the Zika virus IgG antibodies is only used to aid in the interpretation of the IgM result and should not be used individually to determine the patient's Zika IgG status.
Part Descriptions
LP221384-3 Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. PMID: 27417494
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. PMID: 27148186
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws.
Source: Regenstrief LOINC
, PMID: 27417494
Fully-Specified Name
- Component
- Zika virus non-structural protein 1 Ab.IgM
- Property
- Imp
- Time
- Pt
- System
- Ser
- Scale
- Nom
- Method
- IA
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64 (ADD)
- Order vs. Observation
- Observation
Preferred Answer List LL4993-3
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| Presumptive recent Zika negative | LA28914-2 | ||
| Presumptive recent Zika positive | LA28915-9 | ||
| Presumptive Zika IgM positive | LA28916-7 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 89368-5 | Zika virus non-structural protein 1 IgM panel - Serum or Plasma by Immunoassay |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG32774-8 | Zika virus |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Zika-Virus Nichtstrukturprotein 1 Ak.IgM: |
| el-GR | Greek (Greece) | Μη δομική πρωτεΐνη 1 του ιού Ζίκα Αντισώματα IgM: Synonyms: Imp Ανοσοσφαιρίνη M Ιός Ιός Ζίκα Μη δομική πρωτεΐνη 1 του ιού Ζίκα Πρωτεΐνη |
| es-ES | Spanish (Spain) | Proteína no estructural del virus del Zica IgM: |
| es-MX | Spanish (Mexico) | Proteína 1 Ab.IgM no estructural del virus del Zika: |
| fr-FR | French (France) | Zika virus protéine non structurelle 1 Ac IgM: |
| it-IT | Italian (Italy) | Zika virus, proteina non strutturale 1 Ab.IgM: Synonyms: Anticorpi IgM anticorpo Immunoassay Impressione/interpretazione di studio Microbiologia Proteina non strutturale 1 del virus Zika Punto nel tempo (episodio) Siero Virus Zika |
| nl-NL | Dutch (Netherlands) | zikavirus niet-structureel proteïne 1 As.IgM: Synonyms: antistof; |
| zh-CN | Chinese (China) | 寨卡病毒非结构蛋白 1 抗体.IgM: Synonyms: Ⅰ Ab.IgM; |
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