89370-1

Zika virus non-structural protein 1 IgM Ab [Interpretation] in Serum by Immunoassay

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Term Description

Overall interpretation for Zika virus IgM antibody testing based on an algorithm that considers individual quantitative results for IgG and IgM antibodies to Zika virus antigens. This term was created for, but not limited in use to, the submitter's test kit, Diasorin LIAISON(R) XL Zika Capture IgM. In this assay, the result of the Zika virus IgG antibodies is only used to aid in the interpretation of the IgM result and should not be used individually to determine the patient's Zika IgG status.
Source: Regenstrief LOINC

Part Description

LP221384-3   Zika virus non-structural protein 1
The Zika virus (ZIKV) nonstructural protein 1 (NS1) is secreted by infected cells and is involved in immune evasion and pathogenesis. While there is some structural similarity between ZIKV NS1 and NS1 from other flaviviruses, antibodies to ZIKV NS1 have been found to be relatively ZIKV-specific. PMID: 27417494
Zika virus (ZIKV) is a flavivirus transmitted primarily by the Aedes mosquito which was first identified in a sentinel monkey in the Zika forest in Uganda in 1947. Since 2014 it has spread explosively in the Americas where it has infected hundreds of thousands of people. About 80% of those infected are asymptomatic. Common symptoms include fever, headache, rash, arthralgia and conjunctivitis. Since the end of 2015, there has been an increase in ZIKV-associated cases of Guillain-Barre syndrome and a tremendous increase in cases of microcephaly in fetuses and newborns in Brazil, raising worldwide public health concern. Recent predictions are that the mosquito species A. Albopictus, which can hibernate and survive cool temperatures, will carry ZIKV to more temperate areas of North America, Australia and Southern Europe. It is still not clear whether ZIKV in humans increases viral titers enough to trigger a new cycle when an infected person is bitten by a naïve mosquito. Direct human-to-human transmission has been documented to occur perinatally, sexually (primarily through semen), through breastfeeding, blood transfusion and through occupational transmission in the laboratory setting. There are currently no specific anti-viral agents, vaccination or medical prophylaxis available. PMID: 27148186
ZIKV itself can be detected during the acute phase of infection (4-6 days) using PCR-based methods; alternatively, ZIKV-specific IgM antibodies or a significant titer increase of ZIKV-specific IgG is proof of acute infection. Antibody titers should be performed using serum samples from the acute and convalescent stages with at least 2 weeks between blood draws. Source: Regenstrief LOINC, PMID: 27417494

Fully-Specified Name

Component

Zika virus non-structural protein 1 Ab.IgM

Property

Imp

Time

Pt

System

Ser

Scale

Nom

Method

IA

Additional Names

Long Common Name

Zika virus non-structural protein 1 IgM Ab [Interpretation] in Serum by Immunoassay

Short Name

ZIKV NS1 IgM Ser IA-Imp

Display Name

ZIKV non-structural protein 1 IgM IA (S) [Interp]

Consumer Name Alpha Get Info

Zika virus non-structural protein 1 IgM antibody, Blood

Preferred Answer List: LL4993-3

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.64

Last Updated

Version 2.64

Order vs. Observation

Observation

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• i
• IAA
• ID
• Immune globulin M
• Immunoglobulin M
• Impression
• Impression/interpretation of study
• Impressions
• Infectious Disease
• InfectiousDisease
• Interp
• Interpretation
• MEIA
• Microbiology
• Nominal
• Point in time
• PR
• Prot
• Random
• Serum
• SR
• SUDS
• ZIKV
• ZIKV NS1
• ZIKV NS1 Ab

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