90735-2
PNH GPI-Linked WBC and RBC Ag Panel - Blood
Active
33662-8 Erythrocytes.CD59 deficient/Erythrocytes in Blood
Part Descriptions
LP31589-2 Erythrocytes.CD59 deficient
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Erythrocytes.CD59 deficient/Cells.235a
- Property
- NFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.79 (NAM)
- Change Reason
- Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component; Previous Releases: Updated denominator from '100 Red blood cells' to '100 Cells.235a+', where CD235a+ is a marker for RBC, and System from 'RBC' to 'Bld' for consistency across cell marker terms.
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 6120
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 55164-8 | Paroxysmal nocturnal panel - Blood |
| 90735-2 | PNH GPI-Linked WBC and RBC Ag Panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Erythrozyten.CD59 defizient/Zellen.235a: |
| es-MX | Spanish (Mexico) | Eritrocitos Deficiente en CD59 / 100 células.235a: |
| es-ES | Spanish (Spain) | Eritrocitos CD59 deficientes/Porcentaje CD235a: Synonyms: Cuantitativo |
| es-AR | Spanish (Argentina) | eritrocitos.con deficiencia de CD59/100 células: |
| fr-FR | French (France) | Érythrocytes CD59-/100 cellules 235a: |
| fr-CA | French (Canada) | Érythrocytes.CD59 déficients/Cellules.235a: |
| it-IT | Italian (Italy) | Eritrociti.deficit CD59/Cellule.235a: Synonyms: Cellule.235a Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) RBC CD59 RBC deficit CD59 Sangue |
| ko-KR | Korean (Korea, Republic Of) | 적혈구.CD59 결핍/100 세포: |
| nl-NL | Dutch (Netherlands) | erytrocyten.CD59-deficiënt/100 cellen.235a: Synonyms: erytrocyten.CD59 deficient |
| pl-PL | Polish (Poland) | Erytrocyty CD59 ujemne/100 komórek CD235a: Synonyms: CD59 Erytrocyty z nieodoborem CD59/100 komórek 235a Niedobór CD59 |
| pt-BR | Portuguese (Brazil) | Eritrócitos.CD59 deficientes/100 eritrócitos: Synonyms: ; |
| zh-CN | Chinese (China) | 红细胞.CD59 缺乏型/细胞.235a: Synonyms: 1F-5 抗原; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
| % | REGENSTRIEF |
90738-6 Erythrocytes.CD59 complete loss/Erythrocytes in Blood
Term Description
This assay measures the percent of red blood cells that have complete loss of the CD59 antigen. The loss of CD59 is associated with paroxysmal nocturnal hemoglobinuria (PNH), and patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.
Part Descriptions
LP268509-9 Erythrocytes.CD59 complete loss
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Erythrocytes.CD59 complete loss/Cells.235a
- Property
- NFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.79 (NAM)
- Change Reason
- Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 90735-2 | PNH GPI-Linked WBC and RBC Ag Panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Pérdida completa de eritrocitos CD59/Porcentaje CD235a: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Eritrocitos CD59 pérdida completa / 100 células 235a: |
| fr-FR | French (France) | Érythrocytes CD59 perte totale/100 cellules 235a: |
| it-IT | Italian (Italy) | Eritrociti.perdita completa CD59/Cellule.235a: Synonyms: Cellule.235a Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) RBC CD59 RBC perdita completa CD59 Sangue |
| pl-PL | Polish (Poland) | Erytrocyty CD59 ujemne/100 komórek CD235a: Synonyms: CD59 Erytrocyty z całkowitą utratą CD59/100 komórek 235a |
| zh-CN | Chinese (China) | 红细胞.CD59 完全丧失/细胞.235a: Synonyms: CD59 RBC; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90737-8 CD24-FLAER- cells/Cells.CD15 (Neutrophils) in Blood
Part Descriptions
LP268510-7 Cells.CD24-FLAER-
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cells.CD24-FLAER-/Cells.CD15
- Property
- NFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.79 (NAM)
- Change Reason
- Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component; Release 2.72: LONG_COMMON_NAME: Added the cell type name to the display name to align with reference lab convention.;
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 90735-2 | PNH GPI-Linked WBC and RBC Ag Panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Κύτταρα.CD24-FLAER-/Κύτταρα.CD15: Synonyms: CD15 CD24 NFr Κύτταρα Κύτταρα.CD15 Κύτταρα.CD24 Κύτταρα.CD24-FLAER- |
| es-MX | Spanish (Mexico) | Celdas.CD24-FLAER- / 100 células.CD15: |
| es-ES | Spanish (Spain) | Células CD24-FLAER-/Porcentaje CD15: Synonyms: Cuantitativo |
| fr-FR | French (France) | CD24-FLAER-/100 cellules CD15: |
| it-IT | Italian (Italy) | Cellule.CD24-FLAER-/Cellule.CD15: Synonyms: Cellule CD15 Cellule CD24 Cellule CD24-FLAER- Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue |
| zh-CN | Chinese (China) | 细胞.CD24-FLAER-/细胞.CD15: Synonyms: 3-FAL; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90736-0 CD14-FLAER- cells/Cells.CD33 (Monocytes) in Blood
Part Descriptions
LP269194-9 Cells.CD14-FLAER-
Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59.
Source: Regenstrief LOINC
LP17733-4 CD14
Found on Monocytes
Associated with some AML
Source: Regenstrief LOINC
LP20018-5 CD33
Found on granulocyte and monocyte precursors, except stem cells;
Mature monocytes. Weak staining on mature granulocytes.
Associated with AML
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cells.CD14-FLAER-/Cells.CD33
- Property
- NFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.79 (NAM)
- Change Reason
- Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component; Release 2.72: LONG_COMMON_NAME: Added the cell type name to the display name to align with reference lab convention.;
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 90735-2 | PNH GPI-Linked WBC and RBC Ag Panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Κύτταρα.CD14-FLAER-/Κύτταρα.CD33: Synonyms: CD14 CD33 NFr Κύτταρα Κύτταρα.CD14 Κύτταρα.CD14-FLAER- Κύτταρα.CD33 |
| es-MX | Spanish (Mexico) | Celdas.CD14-FLAER- / 100 células.CD33: |
| es-ES | Spanish (Spain) | Células CD14-FLAER-/Porcentaje CD33: Synonyms: Cuantitativo |
| fr-FR | French (France) | CD14-FLAER-/100 cellules CD33: |
| it-IT | Italian (Italy) | Cellule.CD14-FLAER-/Cellule.CD33: Synonyms: Cellule CD14 Cellule CD14-FLAER- Cellule CD33 Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue |
| pl-PL | Polish (Poland) | Komórki.CD14-FLAER-/100 komórek CD33: Synonyms: CD14 CD33 Komórki CD14 Komórki CD14-FLAER- Komórki CD14-FLAER-/100 komórek CD33 |
| zh-CN | Chinese (China) | 细胞.CD14-FLAER-/细胞.CD33: Synonyms: Alexa Fluor 488-标记的气单胞菌溶素突变体 Alexa Fluor 488-标记的气溶毒素突变体 Alexa Fluor 488-标记的气溶素突变体 Alexa Fluor 488-标记的突变体气单胞菌溶素 Alexa Fluor 488-标记的突变体气溶毒素 Alexa Fluor 488-标记的突变体气溶素 Alexa Fluor 488-标记的突变型气单胞菌溶素 Alexa Fluor 488-标记的突变型气溶毒素 Alexa Fluor 488-标记的突变型气溶素 CD14细胞 CD33细胞 Fluor 488-标记的气单胞菌溶素突变体 Fluor 488-标记的气溶毒素突变体 Fluor 488-标记的气溶素突变体 Fluor 488-标记的突变体气单胞菌溶素 Fluor 488-标记的突变体气溶毒素 Fluor 488-标记的突变体气溶素 Fluor 488-标记的突变型气单胞菌溶素 Fluor 488-标记的突变型气溶毒素 Fluor 488-标记的突变型气溶素 Fluor 488-标记的突变型气溶素（Fluor 488-labeled mutant aerolysin， |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |