90805-3

Vedolizumab [Mass/volume] in Serum or Plasma by LC/MS/MS --trough

Active

Term Description

Vedolizumab trough levels are measured immediately before the next scheduled dose.

Part Descriptions

LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Trough levels for therapeutic drug monitoring

LP250843-2 Vedolizumab
Vedolizumab is a monoclonal antibody used in the treatment of inflammatory bowel disease (IBD) including the subtypes Ulcerative colitis and Crohn's disease. IBD involves inflammation of the intestinal mucosa by leukocytes that cause a disruption in its barrier function. The leukocytes involved are T-cells that express α4β7 integrins which are the target for the drug vedolizumab. Vedolizumab prevents α4β7 integrin from binding with the endothelial surface and T-cells from penetrating the intestinal mucosa. Vedolizumab has proven to be a safe and effective treatment for IBD based in clinical research. Clinical studies have shown that vedolizumab helps achieve corticosteroid-free clinical remission. PMID: 27003961 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Vedolizumab^trough:MCnc:Pt:Ser/Plas:Qn:LC/MS/MS
Long Common Name: Vedolizumab [Mass/volume] in Serum or Plasma by LC/MS/MS --trough
Short Name: Vedolizumab Trough SerPl LC/MS/MS-mCnc
Display Name: Vedolizumab trough LC/MS/MS [Mass/Vol]
Consumer Name Alpha Get Info: Vedolizumab trough, Blood

Part Model Get Info

Component
Vedolizumab^trough
LP308057-1
- Analyte
  Vedolizumab
  LP250843-2
  - Component Numerator
    Vedolizumab
    LP250843-2
    - Component Numerator Core
      Vedolizumab
      LP250843-2
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  trough
  LP20176-1
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
LC/MS/MS
LP95062-3

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.65
Last Updated: Version 2.65 (ADD)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
90794-9	Vedolizumab and Vedolizumab Ab panel [Mass/volume] - Serum or Plasma

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Vedolizumab^Údolní koncentrace:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Kapalinová chromatografie s tandemovou hmotnostní spektrometrií (LC/MS/MS)
el-GR	Greek (Greece)	Βεδολιζουμάμπη^ελάχιστα επίπεδα:MCnc:Pt:Ορός/Πλάσμα:Qn:LC/MS/MS Synonyms: DRUG/TOX LC/MS/MS MCnc Pt Qn Βεδολιζουμάμπη ελάχιστα επίπεδα Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	Vedolizumab^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:LC/MS/MS Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Vedolizumab ^ a través:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:LC / MS / MS
fr-FR	French (France)	Védolizumab^taux résiduel:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:LC/MS/MS
it-IT	Italian (Italy)	Vedolizumab^valore minimo:MCnc:Pt:Siero/Plasma:Qn:LC/MS/MS Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM
zh-CN	Chinese (China)	维多珠单抗^波谷:质量浓度:时间点:血清/血浆:定量型:LC/MS/MS Synonyms: Tandem Mass Spectrometry;MS/MS;串联质谱分析;串联质谱法;mass spectrometer;MS;质谱法;质谱分析;liquid chromatography;LC;液相色谱分析;Liquid Chromatography-Tandem Mass Spectrometry;liquid chromatography-MS/MS;LC-MS/MS;液相色谱分析-串联质谱分析法;液相色谱-串联质谱检测方法;液相色谱质谱联用技术;串联质谱快速分析一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 维多珠;Vedolizumab 单抗;维多株单抗;维多珠单克隆抗体药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
ug/mL	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90805-3

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.