Version 2.80

Term Description

Vedolizumab trough levels are measured immediately before the next scheduled dose.

Part Descriptions

LP20176-1   trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Trough levels for therapeutic drug monitoring

LP250843-2   Vedolizumab
Vedolizumab is a monoclonal antibody used in the treatment of inflammatory bowel disease (IBD) including the subtypes Ulcerative colitis and Crohn's disease. IBD involves inflammation of the intestinal mucosa by leukocytes that cause a disruption in its barrier function. The leukocytes involved are T-cells that express α4β7 integrins which are the target for the drug vedolizumab. Vedolizumab prevents α4β7 integrin from binding with the endothelial surface and T-cells from penetrating the intestinal mucosa. Vedolizumab has proven to be a safe and effective treatment for IBD based in clinical research. Clinical studies have shown that vedolizumab helps achieve corticosteroid-free clinical remission. PMID: 27003961 Source: Regenstrief LOINC

Fully-Specified Name

Component
Vedolizumab^trough
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
LC/MS/MS

Additional Names

Long Common Name
Vedolizumab [Mass/volume] in Serum or Plasma by LC/MS/MS --trough
Short Name
Vedolizumab Trough SerPl LC/MS/MS-mCnc
Display Name
Vedolizumab trough LC/MS/MS [Mass/Vol]
Consumer Name Alpha Get Info
Vedolizumab trough, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.65 (ADD)
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
90794-9 Vedolizumab and Vedolizumab Ab panel [Mass/volume] - Serum or Plasma

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Βεδολιζουμάμπη^ελάχιστα επίπεδα:MCnc:Pt:Ορός/Πλάσμα:Qn:LC/MS/MS
Synonyms: MCnc Βεδολιζουμάμπη
es-ES Spanish (Spain) Vedolizumab^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:LC/MS/MS
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Vedolizumab ^ a través:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:LC / MS / MS
fr-FR French (France) Védolizumab taux résiduel:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:LC/MS/MS
it-IT Italian (Italy) Vedolizumab^valore minimo:MCnc:Pt:Siero/Plasma:Qn:LC/MS/MS
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM
zh-CN Chinese (China) 维多珠单抗^波谷:质量浓度:时间点:血清/血浆:定量型:LC/MS/MS
Synonyms: Tandem Mass Spectrometry;MS/MS;串联质谱分析;串联质谱法;mass spectrometer;MS;质谱法;质谱分析;liquid chromatography;LC;液相色谱分析;Liquid Chromatography-Tandem Mass Spectrometry;liquid chromatography-MS/MS;LC-MS/MS;液相色谱分析-串联质谱分析法;液相色谱-串联质谱检测方法;液相色谱质谱联用技术;串联质谱快速分析 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 维多珠;Vedolizumab 单抗;维多株单抗;维多珠单克隆抗体 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90805-3